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Study Information
Study Attribute Value
CEBS Accession Number: 002-02202-0014-0000-3
Chemical Name: Geranyl acetate
CASRN: 105-87-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A07926_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/20/1992 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 303099 50 5 4 0 0 0 1 0 10 0.20 0.12 16.00 12.00
    303100 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303106 50 1 4 0 1 0 0 0 6 0.12 0.02 12.00 2.00
    303107 50 2 10 0 0 0 0 0 12 0.24 0.04 16.00 4.00
    303119 50 2 2 0 0 0 1 0 5 0.10 0.06 10.00 6.00
    303121 50 3 0 0 0 0 0 0 3 0.06 0.06 0.00 6.00
    303123 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303144 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303154 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    303155 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         1.9 2.8 0.0 0.1 0.0 0.3 0.0 5.0 0.10 0.04 7.50 4.25
± SEM                         0.03 0.01 2.47 1.33
 
Positive Control Dimethylbenzanthracene 
200         
 303105 50 3 3 0 1 0 0 0 7 0.14 0.06 12.00 6.00
    303113 50 3 3 0 1 0 0 0 7 0.14 0.06 14.00 6.00
    303114 50 8 9 0 0 0 1 0 18 0.36 0.18 26.00 16.00
    303118 50 4 5 0 0 0 0 0 9 0.18 0.08 16.00 8.00
    303131 50 7 14 0 0 0 1 0 22 0.44 0.16 32.00 14.00
    303133 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303135 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    303141 50 1 0 0 0 0 1 0 2 0.04 0.04 0.00 6.00
    303142 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303150 50 3 2 0 0 0 1 0 6 0.12 0.08 10.00 8.00
Average         3.9 4.5 0.0 0.3 0.0 0.5 0.0 9.1 0.18 0.09 13.75 8.50
± SEM                         0.05 0.02 3.97 1.50
 
Test Chemical Geranyl acetate 
250         
 303098 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    303120 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 4.00
    303122 50 0 5 0 0 0 0 0 5 0.10 0.00 10.00 0.00
    303132 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    303138 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303140 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    303147 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303148 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    303149 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    303151 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 2.0 0.0 0.0 0.0 0.0 0.0 2.8 0.06 0.02 5.25 1.25
± SEM                         0.01 0.01 1.31 0.53
 
Test Chemical Geranyl acetate 
500         
 303102 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    303110 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303125 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303130 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 2.00
    303134 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    303137 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    303139 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    303156 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303157 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    303158 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.9 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.01 2.25 0.75
± SEM                         0.01 0.01 0.80 0.53
 
Test Chemical Geranyl acetate 
1000         
 303097 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303101 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    303108 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    303111 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    303116 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    303117 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    303124 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    303126 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    303136 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    303153 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.8 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.01 1.75 1.25
± SEM                         0.00 0.01 0.59 0.53
 
Vehicle Control No Stressor 
 0         
 303103 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303104 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303109 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    303112 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    303115 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    303127 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    303128 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    303129 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    303143 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    303146 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.9 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.01 1.75 1.00
± SEM                         0.01 0.01 1.03 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation