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Study Information
Study Attribute Value
CEBS Accession Number: 002-02823-0017-0000-5
Chemical Name: Sodium fluoride
CASRN: 7681-49-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A12928_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/20/1991 Bone Marrow 6 Male Mouse B6C3F1 Dosed-Water x 42/study, 6 weeks Negative (Nonstandard Protocol)

  Dose
(ppm)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Cyclophosphamide 
114         
 270013 50 4 2 4 3 0 0 0 13 0.26 0.16 26.00 16.00
    270015 50 6 6 3 0 0 0 0 15 0.30 0.18 24.00 22.00
    270049 50 4 6 0 0 0 0 0 10 0.20 0.08 18.00 8.00
    270069 50 2 3 0 1 0 0 0 6 0.12 0.04 12.00 4.00
    270077 50 4 5 3 1 0 0 0 13 0.26 0.14 16.00 14.00
    270083 50 4 1 0 4 0 0 0 9 0.18 0.08 16.00 8.00
    270084 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    270086 50 3 3 2 0 0 1 0 9 0.18 0.12 12.00 14.00
Average         3.6 3.4 1.5 1.1 0.0 0.1 0.0 9.8 0.20 0.11 16.00 11.25
± SEM                         0.03 0.02 2.48 2.23
 
Test Chemical Sodium fluoride 
100         
 270031 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    270032 50 0 0 1 2 0 1 0 4 0.08 0.04 6.00 4.00
    270048 50 2 1 0 0 0 0 0 3 0.06 0.04 8.00 6.00
    270056 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    270066 50 0 3 1 0 0 0 0 4 0.08 0.02 8.00 2.00
    270078 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    270091 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    270093 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 1.0 0.5 0.3 0.0 0.1 0.0 2.9 0.06 0.03 5.50 3.50
± SEM                         0.01 0.00 0.91 0.50
 
Test Chemical Sodium fluoride 
200         
 270003 50 0 3 0 0 0 0 0 3 0.06 0.00 8.00 2.00
    270025 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    270045 50 1 1 1 1 0 0 0 4 0.08 0.04 6.00 4.00
    270065 50 2 1 0 0 0 1 0 4 0.08 0.06 8.00 6.00
    270067 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    270074 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    270082 50 0 0 0 0 0 0 0 0 0.00 0.00 2.00 2.00
    270088 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
Average         1.0 1.1 0.1 0.1 0.0 0.1 0.0 2.5 0.05 0.03 5.25 3.00
± SEM                         0.01 0.01 0.92 0.53
 
Test Chemical Sodium fluoride 
400         
 270024 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    270033 50 0 1 0 1 0 0 0 2 0.04 0.00 4.00 0.00
    270034 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    270035 50 2 2 1 2 0 0 0 7 0.14 0.06 14.00 6.00
    270043 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    270044 50 0 3 1 0 0 1 0 5 0.10 0.04 10.00 4.00
    270050 50 0 0 0 1 0 0 0 1 0.02 0.00 4.00 2.00
    270057 50 5 0 1 1 0 1 0 8 0.16 0.14 16.00 14.00
Average         1.0 1.1 0.5 0.6 0.0 0.3 0.0 3.5 0.07 0.04 7.25 3.75
± SEM                         0.02 0.02 1.89 1.62
 
Vehicle Control No Stressor 
 0         
 270001 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    270004 50 1 0 0 2 0 0 0 3 0.06 0.02 4.00 2.00
    270012 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    270017 50 2 1 1 0 0 0 0 4 0.08 0.06 6.00 6.00
    270019 50 2 1 0 1 0 0 0 4 0.08 0.04 8.00 4.00
    270030 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    270046 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    270063 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 0.5 0.3 0.5 0.0 0.0 0.0 2.3 0.05 0.03 4.00 2.50
± SEM                         0.01 0.01 0.76 0.73
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation