COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01969-0036-0000-6
Chemical Name: Di(2-ethylhexyl) phthalate
CASRN: 117-81-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A15927_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/30/1984 Bone Marrow 14 Female Mouse B6C3F1 Dosed-Feed x 14/study, 14 days Negative (Nonstandard Protocol)

  Dose
(ppm)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical Di(2-ethylhexyl) phthalate 
3000         
 1589 100 7 1 0 0 0 0 0 8 0.08 0.07 4.00 4.00
    1614 100 2 2 0 0 0 0 1 5 0.05 0.03 4.00 2.00
    1616 100 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1621 100 8 1 0 0 0 1 1 11 0.11 0.10 6.00 5.00
Average         4.3 1.0 0.0 0.0 0.0 0.3 0.5 6.0 0.06 0.05 3.50 2.75
± SEM                         0.02 0.02 1.26 1.11
 
Test Chemical Di(2-ethylhexyl) phthalate 
6000         
 1588 100 1 1 0 0 0 0 0 2 0.02 0.01 2.00 1.00
    1609 100 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1619 100 1 0 0 0 0 0 0 1 0.01 0.01 1.00 1.00
    1626 100 0 2 0 0 0 0 0 2 0.02 0.00 2.00 0.00
Average         0.5 0.8 0.0 0.0 0.0 0.0 0.0 1.3 0.01 0.01 1.25 0.50
± SEM                         0.00 0.00 0.48 0.29
 
Test Chemical Di(2-ethylhexyl) phthalate 
12000         
 1606 100 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1608 100 1 1 0 0 0 0 0 2 0.02 0.01 2.00 1.00
    1613 100 4 1 0 0 1 0 0 6 0.06 0.05 4.00 4.00
    1617 100 1 0 0 0 0 0 0 1 0.01 0.01 1.00 1.00
Average         1.5 0.5 0.0 0.0 0.3 0.0 0.0 2.3 0.02 0.02 1.75 1.50
± SEM                         0.01 0.01 0.85 0.87
 
Vehicle Control No Stressor 
 0         
 1594 100 0 1 0 0 0 0 0 1 0.01 0.00 1.00 0.00
    1600 100 2 0 0 0 0 0 0 2 0.02 0.02 2.00 2.00
    1607 100 4 0 0 0 0 0 0 4 0.04 0.04 2.00 2.00
    1618 100 2 1 0 0 0 0 0 3 0.03 0.02 2.00 1.00
Average         2.0 0.5 0.0 0.0 0.0 0.0 0.0 2.5 0.03 0.02 1.75 1.25
± SEM                         0.01 0.01 0.25 0.48
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation