| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01845-0006-0000-6 |
| Chemical Name: | Chemical mixture - drinking water contaminants |
| CASRN: | CHEMMIXH2O |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | A18666_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 11/24/1987 | Bone Marrow | 24 | Female | Mouse | B6C3F1 | Dosed-Water x 1, 14 hour |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Water |
0 |
6911 | 25 | 8.51 | ± | 0.779 |
| 6913 | 25 | 4.98 | ± | 0.339 | |||
| 6915 | 25 | 8.31 | ± | 0.710 | |||
| 6917 | 25 | 7.25 | ± | 0.695 | |||
| 6919 | 24 | 5.54 | ± | 0.578 | |||
| 6922 | 25 | 7.92 | ± | 0.676 | |||
| 6930 | 25 | 7.69 | ± | 0.463 | |||
| 6938 | 25 | 7.38 | ± | 0.627 | |||
| Average | 7.20 | ± | 0.452 | ||||
| Test Chemical | Chemical mixture - drinking water contaminants |
10 |
6912 | 25 | 9.69 | ± | 0.963 |
| 6927 | 25 | 6.68 | ± | 0.497 | |||
| 6933 | 25 | 4.92 | ± | 0.498 | |||
| 6941 | 25 | 6.98 | ± | 0.486 | |||
| 6943 | 25 | 7.28 | ± | 0.550 | |||
| 6949 | 24 | 10.00 | ± | 0.784 | |||
| 6951 | 25 | 7.48 | ± | 0.671 | |||
| 6954 | 25 | 7.25 | ± | 0.519 | |||
| Average | 7.52 | ± | 0.579 | ||||
| Test Chemical | Chemical mixture - drinking water contaminants |
100 |
6882 | 25 | 6.50 | ± | 0.588 |
| 6884 | 25 | 4.94 | ± | 0.486 | |||
| 6890 | 25 | 4.50 | ± | 0.387 | |||
| 6892 | 25 | 8.26 | ± | 0.874 | |||
| 6909 | 25 | 8.35 | ± | 0.763 | |||
| 6939 | 25 | 5.71 | ± | 0.498 | |||
| 6955 | 24 | 3.68 | ± | 0.375 | |||
| 6958 | 25 | 5.71 | ± | 0.522 | |||
| Average | 5.97 | ± | 0.594 | ||||
| Test Chemical | Chemical mixture - drinking water contaminants |
200 |
6881 | 25 | 6.46 | ± | 0.525 |
| 6889 | 25 | 8.14 | ± | 0.601 | |||
| 6893 | 25 | 7.57 | ± | 0.685 | |||
| 6894 | 25 | 7.00 | ± | 0.766 | |||
| 6896 | 25 | 7.53 | ± | 0.617 | |||
| 6897 | 25 | 10.03 | ± | 0.701 | |||
| 6900 | 25 | 17.74 | ± | 1.078 | |||
| 6904 | 25 | 9.19 | ± | 0.527 | |||
| Average | 9.21 | ± | 1.285 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed