| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01845-0006-0000-6 |
| Chemical Name: | Chemical mixture - drinking water contaminants |
| CASRN: | CHEMMIXH2O |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | A18666_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 11/25/1987 | Bone Marrow | 24 | Male | Mouse | B6C3F1 | Dosed-Water x 1, 14 hour |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Water |
0 |
6916 | 25 | 4.31 | ± | 0.390 |
| 6918 | 25 | 6.06 | ± | 0.340 | |||
| 6920 | 25 | 4.73 | ± | 0.536 | |||
| 6921 | 24 | 4.78 | ± | 0.359 | |||
| 6924 | 25 | 4.63 | ± | 0.505 | |||
| 6926 | 24 | 4.56 | ± | 0.318 | |||
| 6932 | 25 | 4.83 | ± | 0.431 | |||
| 6942 | 24 | 3.82 | ± | 0.362 | |||
| Average | 4.72 | ± | 0.224 | ||||
| Test Chemical | Chemical mixture - drinking water contaminants |
10 |
6914 | 25 | 5.54 | ± | 0.440 |
| 6940 | 25 | 5.97 | ± | 1.487 | |||
| 6945 | 25 | 5.30 | ± | 0.494 | |||
| 6946 | 25 | 6.46 | ± | 0.712 | |||
| 6947 | 25 | 5.49 | ± | 0.434 | |||
| 6948 | 25 | 7.11 | ± | 0.626 | |||
| 6950 | 25 | 4.99 | ± | 0.376 | |||
| 6952 | 24 | 5.44 | ± | 0.555 | |||
| Average | 5.66 | ± | 0.246 | ||||
| Test Chemical | Chemical mixture - drinking water contaminants |
100 |
6883 | 25 | 6.71 | ± | 1.216 |
| 6885 | 25 | 6.34 | ± | 0.476 | |||
| 6898 | 25 | 5.13 | ± | 0.375 | |||
| 6910 | 25 | 5.93 | ± | 0.438 | |||
| 6929 | 25 | 7.85 | ± | 0.925 | |||
| 6944 | 25 | 5.06 | ± | 0.501 | |||
| 6953 | 25 | 5.77 | ± | 0.516 | |||
| 6957 | 25 | 5.30 | ± | 0.353 | |||
| Average | 5.89 | ± | 0.333 | ||||
| Test Chemical | Chemical mixture - drinking water contaminants |
200 |
6886 | 25 | 4.14 | ± | 0.348 |
| 6887 | 23 | 5.02 | ± | 1.199 | |||
| 6888 | 25 | 5.09 | ± | 0.526 | |||
| 6891 | 25 | 5.70 | ± | 0.460 | |||
| 6895 | 24 | 4.26 | ± | 0.414 | |||
| 6899 | 25 | 5.63 | ± | 0.429 | |||
| 6902 | 25 | 7.58 | ± | 0.716 | |||
| 6908 | 25 | 6.25 | ± | 0.486 | |||
| Average | 5.36 | ± | 0.395 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed