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Study Information
Study Attribute Value
CEBS Accession Number: 002-02797-0016-0000-4
Chemical Name: Selenium sulfide
CASRN: 7446-34-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A25043_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/12/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 277094 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277107 50 6 6 1 2 0 0 0 15 0.30 0.14 18.00 10.00
    277117 50 3 1 0 0 0 1 0 5 0.10 0.08 8.00 6.00
    277118 50 19 12 2 2 0 4 1 40 0.80 0.52 42.00 32.00
    277167 50 6 5 0 0 0 1 0 12 0.24 0.14 18.00 10.00
    277186 50 4 10 0 2 0 5 4 25 0.50 0.26 40.00 24.00
    277191 50 6 10 0 0 0 2 0 18 0.36 0.16 26.00 16.00
    277215 50 17 25 0 3 0 0 0 45 0.90 0.34 48.00 24.00
    277219 50 8 6 0 0 0 0 0 14 0.28 0.16 18.00 12.00
    277244 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         8.6 9.4 0.4 1.1 0.0 1.6 0.6 21.8 0.44 0.23 27.25 16.75
± SEM                         0.10 0.05 5.07 3.18
 
Positive Control Dimethylbenzanthracene 
200         
 277121 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277133 50 5 5 0 1 0 1 3 15 0.30 0.18 24.00 18.00
    277144 50 4 7 1 0 0 2 2 16 0.32 0.18 30.00 20.00
    277149 50 5 13 1 0 0 3 1 23 0.46 0.20 24.00 16.00
    277152 50 11 16 1 2 0 0 0 30 0.60 0.24 28.00 20.00
    277162 50 10 18 2 0 0 3 0 33 0.66 0.30 44.00 26.00
    277197 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277212 50 8 11 2 0 0 2 4 27 0.54 0.32 36.00 26.00
    277226 50 8 13 0 3 0 3 1 28 0.56 0.24 38.00 20.00
    277245 50 9 10 0 0 0 4 3 26 0.52 0.32 34.00 26.00
Average         7.5 11.6 0.9 0.8 0.0 2.3 1.8 24.8 0.50 0.25 32.25 21.50
± SEM                         0.05 0.02 2.49 1.40
 
Test Chemical Selenium sulfide 
5         
 277113 50 0 1 0 0 0 1 0 2 0.04 0.02 4.00 2.00
    277127 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    277145 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277146 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    277173 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277188 50 0 1 0 0 0 1 0 2 0.04 0.02 4.00 2.00
    277242 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277247 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    277248 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277250 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.6 0.1 0.0 0.0 0.3 0.0 1.6 0.03 0.02 3.25 2.00
± SEM                         0.01 0.01 1.00 0.65
 
Test Chemical Selenium sulfide 
10         
 277111 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277159 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    277184 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    277200 50 1 5 0 0 0 0 0 6 0.12 0.02 10.00 4.00
    277227 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    277230 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    277232 50 1 0 0 0 0 1 0 2 0.04 0.04 0.00 4.00
    277236 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    277241 50 2 2 0 0 0 1 0 5 0.10 0.06 6.00 4.00
    277246 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 1.4 0.1 0.0 0.0 0.3 0.0 3.0 0.06 0.03 4.25 3.25
± SEM                         0.01 0.01 1.49 0.53
 
Test Chemical Selenium sulfide 
20         
 277114 50 14 11 1 0 0 0 0 26 0.52 0.30 32.00 20.00
    277131 50 6 1 1 1 0 0 0 9 0.18 0.14 16.00 14.00
    277139 50 2 5 1 2 0 0 0 10 0.20 0.06 12.00 6.00
    277142 50 5 5 0 1 0 1 0 12 0.24 0.12 18.00 10.00
    277170 50 4 2 2 0 0 1 0 9 0.18 0.14 16.00 12.00
    277198 50 2 1 0 2 0 0 0 5 0.10 0.04 8.00 4.00
    277209 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277220 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277228 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277234 50 4 6 0 2 0 0 0 12 0.24 0.08 20.00 8.00
Average         4.6 4.0 0.6 1.0 0.0 0.3 0.0 10.5 0.21 0.11 15.50 9.25
± SEM                         0.05 0.03 3.13 2.20
 
Vehicle Control No Stressor 
 0         
 277019 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    277122 50 1 1 0 1 0 0 0 3 0.06 0.02 6.00 2.00
    277128 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    277129 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277132 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    277143 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277187 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    277205 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    277207 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277211 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.6 0.0 0.1 0.0 0.0 0.0 1.5 0.03 0.02 2.25 1.50
± SEM                         0.01 0.01 1.10 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation