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Study Information
Study Attribute Value
CEBS Accession Number: 002-02310-0014-0000-3
Chemical Name: Isobutyraldehyde
CASRN: 78-84-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A27944_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/08/1994 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 377003 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    377061 50 1 5 1 0 0 0 0 7 0.14 0.04 14.00 4.00
    377070 50 6 2 1 0 0 0 0 9 0.18 0.14 14.00 12.00
    377101 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    377113 50 5 8 0 0 0 0 0 13 0.26 0.10 16.00 6.00
    377130 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    377153 50 2 4 0 0 0 0 0 6 0.12 0.04 8.00 4.00
    377169 50 4 5 0 0 0 0 0 9 0.18 0.08 12.00 6.00
    377182 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377194 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         2.6 3.9 0.3 0.0 0.0 0.0 0.0 6.8 0.14 0.06 10.25 4.75
± SEM                         0.03 0.02 1.67 1.25
 
Positive Control Dimethylbenzanthracene 
200         
 377004 50 9 4 0 0 0 0 0 13 0.26 0.18 18.00 14.00
    377012 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377019 50 3 0 1 0 0 0 0 4 0.08 0.08 0.00 6.00
    377039 50 4 9 0 0 0 0 0 13 0.26 0.08 18.00 8.00
    377075 50 7 5 0 0 0 0 0 12 0.24 0.14 18.00 12.00
    377082 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    377139 50 5 4 0 0 0 0 0 9 0.18 0.10 10.00 8.00
    377140 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    377144 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377156 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         3.8 3.6 0.1 0.0 0.0 0.0 0.0 7.5 0.15 0.08 9.75 6.50
± SEM                         0.03 0.02 2.71 1.80
 
Test Chemical Isobutyraldehyde 
500         
 377036 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    377038 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377062 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377066 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377080 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377096 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    377118 50 6 3 0 0 0 1 0 10 0.20 0.14 14.00 10.00
    377183 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377186 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377187 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 0.8 0.0 0.0 0.0 0.1 0.0 1.9 0.04 0.02 2.75 1.75
± SEM                         0.02 0.02 1.77 1.22
 
Test Chemical Isobutyraldehyde 
1000         
 377014 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    377023 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    377047 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377063 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    377117 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377125 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377171 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    377177 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377191 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    377197 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         1.1 0.9 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 3.25 2.25
± SEM                         0.01 0.01 1.25 0.80
 
Test Chemical Isobutyraldehyde 
1500         
 377010 50 2 2 1 1 0 0 0 6 0.12 0.06 10.00 4.00
    377037 50 5 4 2 1 0 0 0 12 0.24 0.14 20.00 10.00
    377081 50 7 6 2 3 0 0 0 18 0.36 0.18 28.00 16.00
    377109 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377121 50 5 3 0 1 0 0 0 9 0.18 0.10 14.00 10.00
    377136 50 11 3 3 2 0 0 0 19 0.38 0.28 22.00 18.00
    377155 50 9 3 2 4 0 0 0 18 0.36 0.22 26.00 18.00
    377163 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377167 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    377168 10 0 1 0 0 0 0 0 1 0.10 0.00 10.00 0.00
Average         5.0 2.6 1.3 1.5 0.0 0.0 0.0 10.4 0.21 0.13 17.14 11.14
± SEM                         0.05 0.03 3.48 2.30
 
Test Chemical Isobutyraldehyde 
2000         
 377002 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377005 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377042 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377052 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377064 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377083 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377090 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377095 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377115 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377165 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377166 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377173 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377176 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377181 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377184 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.00 0.00 0.00 0.00
± SEM                         0.00 0.00 0.00 0.00
 
Vehicle Control No Stressor 
 0         
 377015 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377043 50 3 4 0 0 0 0 0 7 0.14 0.06 12.00 6.00
    377048 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    377053 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377054 50 3 4 0 0 0 0 0 7 0.14 0.06 10.00 6.00
    377055 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    377103 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    377160 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    377185 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    377190 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.1 1.8 0.0 0.0 0.0 0.0 0.0 2.9 0.06 0.02 4.25 2.25
± SEM                         0.02 0.01 1.58 0.96
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation