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Study Information
Study Attribute Value
CEBS Accession Number: 002-02310-0014-0000-3
Chemical Name: Isobutyraldehyde
CASRN: 78-84-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A27944_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/24/1994 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 385018 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    385027 50 4 2 1 0 0 1 0 8 0.16 0.12 14.00 12.00
    385028 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    385046 50 0 7 1 1 0 1 0 10 0.20 0.04 12.00 4.00
    385072 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    385074 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385091 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385102 50 0 4 0 0 0 0 0 4 0.08 0.00 10.00 2.00
    385166 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385185 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.0 2.1 0.3 0.1 0.0 0.3 0.0 3.8 0.08 0.03 6.00 3.25
± SEM                         0.02 0.01 1.89 1.31
 
Positive Control Dimethylbenzanthracene 
200         
 385019 50 13 21 2 1 0 1 0 38 0.76 0.32 32.00 16.00
    385039 50 2 3 0 1 0 0 0 6 0.12 0.04 8.00 4.00
    385056 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    385094 50 12 22 0 0 0 1 0 35 0.70 0.26 32.00 16.00
    385097 50 4 6 1 0 0 0 0 11 0.22 0.10 16.00 8.00
    385131 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385163 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385169 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385181 50 5 8 0 1 0 1 0 15 0.30 0.12 22.00 10.00
    385195 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         4.6 7.8 0.4 0.4 0.0 0.4 0.0 13.5 0.27 0.11 14.50 7.00
± SEM                         0.11 0.04 4.61 2.33
 
Test Chemical Isobutyraldehyde 
1000         
 385005 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385033 50 1 4 0 0 0 0 0 5 0.10 0.02 10.00 2.00
    385063 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385083 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    385135 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    385136 50 0 1 0 0 0 1 0 2 0.04 0.02 4.00 2.00
    385161 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385165 50 3 6 0 0 0 0 0 9 0.18 0.06 14.00 6.00
    385177 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    385191 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
Average         0.6 2.1 0.0 0.0 0.0 0.1 0.0 2.9 0.06 0.02 4.75 1.50
± SEM                         0.02 0.01 1.73 0.73
 
Test Chemical Isobutyraldehyde 
1200         
 385003 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385009 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    385010 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385022 50 3 4 0 0 0 0 0 7 0.14 0.06 10.00 6.00
    385048 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385051 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    385057 50 2 6 0 1 0 0 0 9 0.18 0.04 12.00 4.00
    385125 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385130 50 2 2 1 0 0 0 0 5 0.10 0.06 6.00 4.00
    385192 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 1.5 0.1 0.1 0.0 0.0 0.0 2.9 0.06 0.03 3.50 2.25
± SEM                         0.03 0.01 1.80 0.80
 
Test Chemical Isobutyraldehyde 
1500         
 385002 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385008 50 0 3 2 0 0 0 0 5 0.10 0.04 6.00 4.00
    385011 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385061 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    385101 10 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385134 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    385157 50 5 3 2 3 0 0 0 13 0.26 0.14 12.00 8.00
    385167 50 1 2 0 1 0 0 0 4 0.08 0.02 8.00 2.00
    385186 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    385188 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.4 1.4 0.6 0.6 0.0 0.0 0.0 4.0 0.08 0.04 5.67 3.67
± SEM                         0.03 0.02 1.54 0.88
 
Test Chemical Isobutyraldehyde 
1750         
 385043 50 1 0 0 4 0 0 0 5 0.10 0.02 8.00 2.00
    385064 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385088 50 4 1 1 4 0 0 0 10 0.20 0.10 12.00 8.00
    385095 50 4 3 1 1 0 0 0 9 0.18 0.10 14.00 8.00
    385096 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385113 50 3 5 3 2 0 0 0 13 0.26 0.12 24.00 12.00
    385149 50 2 5 1 2 0 0 0 10 0.20 0.06 20.00 6.00
    385150 50 1 0 0 3 0 1 0 5 0.10 0.04 8.00 4.00
    385156 50 8 4 7 3 0 0 0 22 0.44 0.30 30.00 22.00
    385198 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         3.3 2.6 1.9 2.7 0.0 0.1 0.0 10.6 0.21 0.11 16.57 8.86
± SEM                         0.04 0.04 3.17 2.50
 
Vehicle Control No Stressor 
 0         
 385014 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385037 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    385042 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    385076 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    385078 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385098 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    385117 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    385139 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    385146 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    385154 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.6 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.02 1.50 1.50
± SEM                         0.01 0.01 0.82 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation