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Study Information
Study Attribute Value
CEBS Accession Number: 002-02758-0005-0000-9
Chemical Name: Pyrilamine maleate
CASRN: 59-33-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A32244_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/09/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 360002 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    360020 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    360046 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    360051 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360116 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360118 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    360124 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    360126 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360194 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360198 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
Average         0.9 0.4 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 1.50 1.75
± SEM                         0.01 0.00 0.73 0.45
 
Positive Control Mitomycin-C 
2         
 360018 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    360050 50 2 3 0 1 0 0 0 6 0.12 0.04 8.00 4.00
    360089 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360104 50 3 0 0 0 0 0 0 3 0.06 0.06 0.00 6.00
    360106 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360138 50 2 0 0 0 0 0 1 3 0.06 0.06 0.00 6.00
    360159 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    360175 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360178 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360185 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
Average         1.4 0.8 0.0 0.1 0.0 0.0 0.1 2.4 0.05 0.03 2.00 3.00
± SEM                         0.01 0.01 1.07 0.85
 
Test Chemical Pyrilamine maleate 
20         
 360016 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360025 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360037 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360057 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    360071 50 0 0 1 0 0 0 0 1 0.02 0.02 0.00 2.00
    360075 50 1 3 0 1 0 0 0 5 0.10 0.02 8.00 2.00
    360086 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360101 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360119 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    360125 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.4 0.5 0.1 0.1 0.0 0.0 0.0 1.1 0.02 0.01 1.25 1.00
± SEM                         0.01 0.00 1.00 0.38
 
Test Chemical Pyrilamine maleate 
40         
 360022 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360026 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360052 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    360095 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360147 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    360177 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360180 50 1 0 0 1 0 0 0 2 0.04 0.02 4.00 2.00
    360184 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    360190 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360191 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.3 0.0 0.1 0.0 0.0 0.0 0.6 0.01 0.01 1.00 0.50
± SEM                         0.01 0.00 0.53 0.33
 
Test Chemical Pyrilamine maleate 
60         
 360017 50 2 0 1 0 0 0 0 3 0.06 0.06 0.00 6.00
    360021 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360032 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    360090 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    360092 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    360109 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360113 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360152 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360157 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360182 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 0.8 0.1 0.0 0.0 0.0 0.0 1.4 0.03 0.01 2.00 1.25
± SEM                         0.01 0.01 1.00 0.75
 
Test Chemical Pyrilamine maleate 
80         
 360008 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    360030 50 0 0 1 1 0 0 0 2 0.04 0.02 2.00 2.00
    360056 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    360065 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360153 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360168 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360171 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    360172 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    360179 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    360195 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.4 0.9 0.1 0.3 0.0 0.0 0.0 1.6 0.03 0.01 3.00 1.00
± SEM                         0.01 0.01 0.76 0.53
 
Vehicle Control No Stressor 
 0         
 360063 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360066 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    360080 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360093 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360142 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    360151 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    360162 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    360186 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    360189 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    360199 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.4 0.5 0.0 0.1 0.0 0.0 0.0 1.0 0.02 0.01 1.50 0.75
± SEM                         0.01 0.00 0.63 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation