| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02254-0007-0000-2 |
| Chemical Name: | Hexamethylphosphoramide |
| CASRN: | 680-31-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | A48570_CA |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
|---|---|---|---|---|---|---|---|
| 06/07/1983 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive (Nonstandard Protocol) |
| Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
| (+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
| Test Chemical | Hexamethylphosphoramide |
500 |
1033 | 100 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0.05 | 0.05 | 4.00 | 4.00 |
| 1035 | 100 | 10 | 1 | 0 | 0 | 0 | 0 | 0 | 11 | 0.11 | 0.10 | 10.00 | 10.00 | |||
| 1036 | 100 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0.06 | 0.06 | 4.00 | 4.00 | |||
| 1140 | 100 | 4 | 1 | 1 | 1 | 0 | 0 | 0 | 7 | 0.07 | 0.05 | 6.00 | 5.00 | |||
| Average | 6.3 | 0.5 | 0.3 | 0.3 | 0.0 | 0.0 | 0.0 | 7.3 | 0.07 | 0.07 | 6.00 | 5.75 | ||||
| ± SEM | 0.01 | 0.01 | 1.41 | 1.44 | ||||||||||||
| Test Chemical | Hexamethylphosphoramide |
1000 |
1037 | 100 | 7 | 0 | 0 | 0 | 1 | 0 | 3 | 11 | 0.11 | 0.11 | 10.00 | 10.00 |
| 1038 | 100 | 13 | 4 | 0 | 0 | 0 | 0 | 0 | 17 | 0.17 | 0.13 | 15.00 | 13.00 | |||
| 1039 | 100 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0.07 | 0.07 | 5.00 | 5.00 | |||
| 1040 | 100 | 4 | 3 | 0 | 0 | 0 | 0 | 3 | 10 | 0.10 | 0.07 | 9.00 | 7.00 | |||
| Average | 7.8 | 1.8 | 0.0 | 0.0 | 0.3 | 0.0 | 1.5 | 11.3 | 0.11 | 0.10 | 9.75 | 8.75 | ||||
| ± SEM | 0.02 | 0.02 | 2.06 | 1.75 | ||||||||||||
| Test Chemical | Hexamethylphosphoramide |
2000 |
1042 | 100 | 6 | 4 | 1 | 0 | 0 | 0 | 0 | 11 | 0.11 | 0.07 | 8.00 | 6.00 |
| 1043 | 100 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 0.03 | 0.03 | 3.00 | 3.00 | |||
| 1044 | 100 | 7 | 0 | 3 | 0 | 2 | 0 | 2 | 14 | 0.14 | 0.14 | 8.00 | 8.00 | |||
| 1045 | 100 | 4 | 0 | 0 | 0 | 1 | 0 | 3 | 8 | 0.08 | 0.08 | 8.00 | 8.00 | |||
| Average | 4.5 | 1.0 | 1.0 | 0.0 | 0.8 | 0.0 | 1.8 | 9.0 | 0.09 | 0.08 | 6.75 | 6.25 | ||||
| ± SEM | 0.02 | 0.02 | 1.25 | 1.18 | ||||||||||||
| Vehicle Control | No Stressor |
0 |
1062 | 100 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.01 | 0.01 | 1.00 | 1.00 |
| 1063 | 100 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.03 | 0.03 | 2.00 | 2.00 | |||
| 1065 | 100 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.01 | 0.01 | 1.00 | 1.00 | |||
| 1066 | 100 | 3 | 1 | 1 | 0 | 1 | 0 | 1 | 7 | 0.07 | 0.06 | 5.00 | 5.00 | |||
| Average | 2.0 | 0.3 | 0.3 | 0.0 | 0.3 | 0.0 | 0.3 | 3.0 | 0.03 | 0.03 | 2.25 | 2.25 | ||||
| ± SEM | 0.01 | 0.01 | 0.95 | 0.95 | ||||||||||||
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation