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Study Information
Study Attribute Value
CEBS Accession Number: 002-02857-0010-0000-5
Chemical Name: Sulfapyridine
CASRN: 144-83-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A49990_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/11/1992 Bone Marrow 72 Male Mouse B6C3F1 Gavage x 3/study, 72 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 294011 50 12 16 0 0 0 1 0 29 0.58 0.26 34.00 22.00
    294014 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294024 50 6 16 0 0 0 0 0 22 0.44 0.12 30.00 12.00
    294029 50 4 3 0 0 0 1 0 8 0.16 0.10 14.00 10.00
    294032 50 10 12 0 1 0 0 0 23 0.46 0.20 28.00 18.00
    294040 50 7 9 0 0 0 1 0 17 0.34 0.16 28.00 12.00
    294045 50 6 3 0 0 0 1 0 10 0.20 0.14 14.00 10.00
    294057 50 7 10 0 1 0 3 0 21 0.42 0.20 24.00 16.00
    294061 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294062 50 19 18 0 0 0 1 0 38 0.76 0.40 34.00 26.00
Average         8.9 10.9 0.0 0.3 0.0 1.0 0.0 21.0 0.42 0.20 25.75 15.75
± SEM                         0.07 0.03 2.81 2.09
 
Test Chemical Sulfapyridine 
500         
 294009 50 0 0 0 0 0 1 0 1 0.02 0.02 0.00 2.00
    294015 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    294020 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294022 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294023 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294031 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    294034 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    294054 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294055 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294065 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.4 0.6 0.0 0.0 0.0 0.1 0.0 1.1 0.02 0.01 1.75 1.00
± SEM                         0.01 0.00 0.88 0.38
 
Test Chemical Sulfapyridine 
1000         
 294004 50 1 5 0 0 0 0 0 6 0.12 0.02 12.00 2.00
    294006 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294017 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    294018 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294021 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294025 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    294026 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    294035 31 2 1 0 0 0 0 0 3 0.10 0.06 9.68 6.45
    294036 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294041 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
Average         0.5 1.3 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.01 9.68 6.45
± SEM                         0.02 0.01 1.67 0.56
 
Test Chemical Sulfapyridine 
2000         
 294003 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294008 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    294010 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294012 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    294019 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    294028 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    294039 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    294042 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294047 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294050 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 1.0 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.01 3.00 1.00
± SEM                         0.01 0.01 1.13 0.53
 
Vehicle Control No Stressor 
 0         
 294001 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    294007 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294016 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    294030 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    294033 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294046 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    294048 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    294049 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    294060 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    294063 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 0.4 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.02 1.25 2.00
± SEM                         0.01 0.01 0.65 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation