COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02479-0002-0000-6
Chemical Name: Mitomycin C
CASRN: 50-07-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A55574_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/10/1987 Bone Marrow 19 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 19 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical Mitomycin C 
1         
 53068 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    53069 10 0 0 0 0 0 0 0 0 0.00 0.00 0.00 10.00
    53077 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53078 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53079 68 5 0 0 0 0 0 0 5 0.07 0.07 0.00 7.35
    53119 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53120 50 1 0 0 0 0 1 0 2 0.04 0.04 0.00 2.00
    53127 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53129 87 1 1 0 0 0 0 0 2 0.02 0.01 0.00 2.30
    53130 34 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.01 0.01 0.00 7.35
± SEM                         0.01 0.01 0.00 0.30
 
Test Chemical Mitomycin C 
1.5       
 53044 50 1 0 0 0 0 1 0 2 0.04 0.04 10.00 0.00
    53128 27 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53133 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    53134 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53135 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53136 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53151 50 0 0 0 0 0 1 0 1 0.02 0.02 0.00 4.00
    53152 54 0 1 0 0 0 0 0 1 0.02 0.00 0.00 3.70
    53165 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53166 37 0 0 0 0 0 0 0 0 0.00 0.00 0.00 2.70
Average         0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.4 0.01 0.01 1.67 3.70
± SEM                         0.01 0.01 1.36 0.56
 
Test Chemical Mitomycin C 
3.5       
 53173 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53174 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53183 39 1 0 0 0 0 0 0 1 0.03 0.03 0.00 2.56
    53184 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    53185 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53187 50 1 0 0 0 0 4 0 5 0.10 0.10 0.00 12.00
    53189 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53190 50 1 0 0 0 0 1 0 2 0.04 0.04 0.00 4.00
    53191 8 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53192 4 1 0 0 0 0 0 0 1 0.25 0.25 0.00 25.00
Average         0.5 0.0 0.0 0.0 0.0 0.8 0.0 1.3 0.04 0.04 0.00 6.00
± SEM                         0.02 0.02 0.00 2.16
 
Vehicle Control No Stressor 
 0         
 53023 8 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53055 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53056 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53061 44 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53062 50 0 0 0 0 0 1 0 1 0.02 0.02 2.00 0.00
    53063 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53064 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53066 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53181 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    53182 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 2.00
Average         0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.00 0.00 0.25 0.25
± SEM                         0.00 0.00 0.22 0.22
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation