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Study Information
Study Attribute Value
CEBS Accession Number: 002-01633-0017-0000-3
Chemical Name: Allyl isothiocyanate
CASRN: 57-06-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A59578_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/19/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 277008 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277034 50 11 8 0 2 0 2 4 27 0.54 0.34 44.00 30.00
    277109 50 8 6 0 2 0 2 0 18 0.36 0.20 26.00 16.00
    277136 50 8 5 0 0 0 1 0 14 0.28 0.18 16.00 12.00
    277147 50 1 2 0 0 0 0 1 4 0.08 0.04 6.00 4.00
    277150 50 2 0 1 0 0 0 0 3 0.06 0.06 0.00 6.00
    277153 50 7 8 0 0 0 3 2 20 0.40 0.24 26.00 20.00
    277156 50 9 11 0 1 0 0 0 21 0.42 0.18 26.00 18.00
    277172 50 11 7 0 0 0 1 0 19 0.38 0.24 18.00 10.00
    277176 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         6.3 5.2 0.1 0.6 0.0 1.0 0.8 14.0 0.28 0.16 20.25 14.50
± SEM                         0.06 0.03 4.54 2.80
 
Test Chemical Allyl isothiocyanate 
25         
 277009 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277125 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277138 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277154 50 3 0 0 0 0 0 0 3 0.06 0.06 0.00 6.00
    277166 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    277175 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277177 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277192 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277196 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    277224 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 1.25 1.25
± SEM                         0.01 0.01 0.61 0.71
 
Test Chemical Allyl isothiocyanate 
50         
 277032 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277086 50 1 2 0 1 0 0 0 4 0.08 0.02 6.00 2.00
    277112 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277120 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277140 50 2 9 0 3 0 0 0 14 0.28 0.04 22.00 4.00
    277169 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    277201 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277202 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277225 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277237 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.3 0.0 0.4 0.0 0.0 0.0 2.1 0.04 0.01 4.25 1.00
± SEM                         0.03 0.00 2.42 0.48
 
Vehicle Control No Stressor 
 0         
 277116 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277163 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    277180 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    277181 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    277195 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277206 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277208 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277223 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277238 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    277239 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
Average         0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.7 0.01 0.01 1.50 0.75
± SEM                         0.01 0.00 0.65 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation