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Study Information
Study Attribute Value
CEBS Accession Number: 002-02324-0014-0000-8
Chemical Name: Isoprene
CASRN: 78-79-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A63977_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/21/1986 Bone Marrow 2 Male Mouse B6C3F1 Inhalation x 10/study, 2 weeks Negative (Nonstandard Protocol)

  Dose
(ppm)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical Isoprene 
438         
 4433 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    4438 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    4440 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4444 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    4466 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4469 50 1 2 0 0 0 0 0 3 0.06 0.02 2.00 2.00
    4473 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    4476 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         2.0 1.3 0.0 0.0 0.0 0.0 0.0 3.3 0.07 0.04 5.75 3.75
± SEM                         0.01 0.01 0.96 1.03
 
Test Chemical Isoprene 
1750         
 4435 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4437 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4446 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 8.00
    4448 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    4455 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4457 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    4478 50 1 1 0 0 0 0 0 2 0.04 0.02 14.00 2.00
    4481 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         2.1 0.6 0.0 0.0 0.0 0.0 0.0 2.8 0.06 0.04 6.75 4.50
± SEM                         0.01 0.01 1.64 1.30
 
Test Chemical Isoprene 
7000         
 4425 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4434 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    4436 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
    4450 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4461 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    4463 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    4465 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    4468 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.8 1.3 0.0 0.0 0.0 0.0 0.0 3.0 0.06 0.04 5.25 3.50
± SEM                         0.01 0.01 1.00 0.73
 
Vehicle Control No Stressor 
 0         
 4432 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    4452 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4458 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    4459 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4462 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4464 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4470 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    4474 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.3 1.1 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.03 4.25 2.25
± SEM                         0.01 0.01 1.22 0.70
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation