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Study Information
Study Attribute Value
CEBS Accession Number: 002-02755-0006-0000-7
Chemical Name: Pyrene
CASRN: 129-00-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A72952_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/11/1984 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical Pyrene 
500         
 1279 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1282 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1286 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1290 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1294 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1302 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1306 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1309 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.00 0.00 0.25 0.25
± SEM                         0.00 0.00 0.25 0.25
 
Test Chemical Pyrene 
1000         
 1280 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1281 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1284 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1287 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1288 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1291 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1296 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1311 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
Average         0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.01 0.01 0.75 0.75
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Pyrene 
2000         
 1277 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    1292 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1297 50 0 0 0 0 0 0 0 0 0.00 0.00 2.00 2.00
    1299 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1304 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1307 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1313 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    1314 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.5 0.5 0.0 0.0 0.0 0.0 0.1 1.1 0.02 0.01 2.00 1.25
± SEM                         0.01 0.01 0.93 0.53
 
Vehicle Control No Stressor 
 0         
 1285 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    1289 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1293 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1298 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1300 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1301 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1308 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1318 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.4 0.01 0.01 0.50 0.25
± SEM                         0.00 0.00 0.33 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation