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Study Information
Study Attribute Value
CEBS Accession Number: 002-02755-0006-0000-7
Chemical Name: Pyrene
CASRN: 129-00-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A72952_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/15/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7123 50 15 4 0 0 0 0 0 19 0.38 0.30 34.00 28.00
    7132 50 32 12 0 1 0 0 0 45 0.90 0.64 36.00 32.00
    7147 50 60 28 0 0 1 0 1 90 1.80 1.24 56.00 42.00
    7170 50 63 13 2 1 0 1 0 80 1.60 1.32 42.00 34.00
    7176 50 75 10 0 1 0 0 1 87 1.74 1.52 46.00 40.00
    7179 50 78 13 0 0 0 0 0 91 1.82 1.56 44.00 44.00
    7190 50 40 6 0 0 0 1 1 48 0.96 0.84 30.00 28.00
    7193 50 62 14 2 0 0 0 0 78 1.56 1.28 40.00 32.00
Average         53.1 12.5 0.5 0.4 0.1 0.3 0.4 67.3 1.35 1.09 41.00 35.00
± SEM                         0.19 0.16 2.85 2.20
 
Test Chemical Pyrene 
200         
 7130 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7134 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7135 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7143 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7146 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7148 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7154 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    7156 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.5 1.0 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.01 3.00 1.00
± SEM                         0.01 0.01 0.76 0.53
 
Test Chemical Pyrene 
400         
 7125 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    7131 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 2.00
    7133 50 4 1 0 1 0 0 0 6 0.12 0.08 10.00 6.00
    7136 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    7151 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7159 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7160 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7161 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
Average         1.3 1.0 0.0 0.1 0.0 0.0 0.0 2.4 0.05 0.03 4.25 2.25
± SEM                         0.01 0.01 1.16 0.88
 
Test Chemical Pyrene 
800         
 7124 50 2 1 0 1 0 0 1 5 0.10 0.06 6.00 4.00
    7126 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7127 50 7 4 1 1 0 1 0 14 0.28 0.18 24.00 16.00
    7138 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7140 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    7150 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    7157 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    7162 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.6 1.0 0.1 0.3 0.0 0.1 0.4 3.5 0.07 0.05 5.50 3.50
± SEM                         0.03 0.02 2.72 1.84
 
Vehicle Control No Stressor 
 0         
 7128 50 3 2 0 0 0 0 1 6 0.12 0.08 10.00 6.00
    7137 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    7142 50 0 5 0 0 0 0 0 5 0.10 0.00 10.00 0.00
    7145 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7165 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 2.00
    7167 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    7178 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7195 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
Average         1.0 1.8 0.0 0.0 0.0 0.0 0.4 3.1 0.06 0.03 5.50 2.25
± SEM                         0.01 0.01 1.12 0.70
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation