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Study Information
Study Attribute Value
CEBS Accession Number: 002-02755-0006-0000-7
Chemical Name: Pyrene
CASRN: 129-00-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A72952_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/04/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 8393 50 7 11 0 1 1 0 0 20 0.40 0.16 20.00 12.00
    8405 50 6 6 0 0 0 0 0 12 0.24 0.12 20.00 12.00
    8419 50 18 17 0 1 0 0 0 36 0.72 0.36 36.00 22.00
    8434 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 6.00
    8439 50 9 3 0 0 0 0 0 12 0.24 0.18 22.00 18.00
    8446 50 25 24 0 0 0 0 1 50 1.00 0.52 48.00 30.00
    8467 50 8 9 0 0 0 0 0 17 0.34 0.16 24.00 14.00
    8480 50 20 17 0 0 0 0 0 37 0.74 0.40 36.00 24.00
Average         12.1 11.3 0.0 0.3 0.1 0.0 0.1 23.9 0.48 0.25 27.25 17.25
± SEM                         0.11 0.06 4.14 2.75
 
Test Chemical Pyrene 
1500         
 8392 50 0 1 0 0 0 0 0 1 0.02 0.00 4.00 2.00
    8397 50 3 4 0 0 0 0 0 7 0.14 0.06 6.00 4.00
    8408 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    8409 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    8410 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    8414 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    8417 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    8427 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.0 1.9 0.0 0.0 0.0 0.0 0.1 3.0 0.06 0.02 4.25 2.00
± SEM                         0.02 0.01 1.03 0.65
 
Test Chemical Pyrene 
2000         
 8395 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8399 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8401 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    8403 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    8411 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8420 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    8424 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8426 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
Average         0.4 1.5 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.01 3.25 0.75
± SEM                         0.01 0.00 0.92 0.37
 
Test Chemical Pyrene 
2500         
 8400 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8402 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8415 50 0 3 1 0 0 0 1 5 0.10 0.04 6.00 2.00
    8416 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    8421 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8422 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    8428 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8429 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.5 0.1 0.0 0.0 0.0 0.1 2.1 0.04 0.01 3.50 1.00
± SEM                         0.02 0.01 1.30 0.53
 
Vehicle Control No Stressor 
 0         
 8396 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8418 50 0 0 0 0 0 0 2 2 0.04 0.04 0.00 0.00
    8425 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8438 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8441 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8442 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8450 50 10 0 0 0 0 0 0 10 0.20 0.20 2.00 2.00
    8472 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.4 0.6 0.0 0.0 0.0 0.0 0.3 2.3 0.05 0.03 1.75 0.50
± SEM                         0.02 0.02 0.45 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation