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Study Information
Study Attribute Value
CEBS Accession Number: 002-03205-0021-0000-5
Chemical Name: t-Butylhydroquinone
CASRN: 1948-33-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A73022_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/16/1994 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
200         
 380010 50 12 3 1 0 0 0 0 16 0.32 0.26 20.00 20.00
    380032 50 9 2 0 0 0 0 0 11 0.22 0.18 14.00 12.00
    380033 50 8 8 0 0 0 0 0 16 0.32 0.16 24.00 14.00
    380053 50 10 16 0 1 0 0 0 27 0.54 0.20 20.00 16.00
    380056 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380074 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    380076 50 4 1 0 1 0 0 0 6 0.12 0.08 12.00 8.00
    380087 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380090 50 5 6 1 0 0 1 0 13 0.26 0.14 18.00 12.00
    380092 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         6.8 5.0 0.3 0.3 0.0 0.1 0.0 12.4 0.25 0.14 16.00 11.75
± SEM                         0.05 0.03 2.17 1.91
 
Test Chemical t-Butylhydroquinone 
50         
 380004 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    380028 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    380030 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    380036 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    380038 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380047 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    380061 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380083 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    380085 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    380097 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 1.3 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 3.50 1.50
± SEM                         0.01 0.01 1.12 0.73
 
Test Chemical t-Butylhydroquinone 
100         
 380001 50 2 4 0 2 0 0 0 8 0.16 0.04 10.00 4.00
    380057 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380066 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    380069 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    380075 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    380079 50 3 5 0 1 0 0 0 9 0.18 0.06 16.00 6.00
    380081 50 2 2 0 0 0 1 0 5 0.10 0.06 10.00 6.00
    380084 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    380088 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380096 50 3 5 0 0 0 0 0 8 0.16 0.06 12.00 6.00
Average         1.4 2.8 0.0 0.4 0.0 0.1 0.0 4.6 0.09 0.03 7.50 3.00
± SEM                         0.02 0.01 1.92 1.00
 
Test Chemical t-Butylhydroquinone 
150         
 380002 50 2 1 1 1 0 0 0 5 0.10 0.06 10.00 6.00
    380013 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    380014 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    380019 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380027 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380042 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    380048 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    380064 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    380065 50 9 3 0 1 0 0 0 13 0.26 0.18 20.00 14.00
    380068 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.8 1.5 0.1 0.3 0.0 0.0 0.0 3.6 0.07 0.04 6.25 3.25
± SEM                         0.03 0.02 2.19 1.73
 
Test Chemical t-Butylhydroquinone 
200         
 380008 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380009 50 23 8 0 0 0 9 1 41 0.82 0.66 30.00 26.00
    380015 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    380026 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    380045 50 4 4 0 1 0 0 0 9 0.18 0.08 14.00 6.00
    380046 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380051 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    380063 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380072 50 2 4 0 0 0 0 0 6 0.12 0.04 6.00 4.00
    380100 50 3 8 0 1 0 0 0 12 0.24 0.06 16.00 6.00
Average         4.4 3.4 0.0 0.3 0.0 1.1 0.1 9.3 0.19 0.11 9.50 6.00
± SEM                         0.10 0.08 3.58 2.95
 
Vehicle Control No Stressor 
 0         
 380003 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    380016 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    380018 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    380022 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380024 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    380031 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    380050 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    380055 50 1 2 0 0 0 0 0 3 0.06 0.02 2.00 2.00
    380077 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    380095 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 1.0 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.02 2.50 1.75
± SEM                         0.01 0.01 0.63 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation