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Study Information
Study Attribute Value
CEBS Accession Number: 002-01698-0011-0000-8
Chemical Name: Benzo(a)pyrene
CASRN: 50-32-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A76267_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/09/1984 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical Benzo(a)pyrene 
62.5       
 1033 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    1036 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1041 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    1049 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1051 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    1052 50 0 1 0 0 1 0 0 2 0.04 0.02 4.00 2.00
    1053 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1063 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.3 0.4 0.0 0.0 0.1 0.0 0.4 1.1 0.02 0.02 1.50 0.75
± SEM                         0.01 0.01 0.63 0.37
 
Test Chemical Benzo(a)pyrene 
125         
 1034 50 0 3 0 0 0 0 1 4 0.08 0.02 4.00 0.00
    1043 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1054 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    1055 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    1057 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1058 50 3 1 1 0 0 0 0 5 0.10 0.08 6.00 6.00
    1066 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1068 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.5 0.6 0.1 0.0 0.0 0.0 0.4 1.6 0.03 0.02 1.75 1.00
± SEM                         0.01 0.01 0.80 0.76
 
Test Chemical Benzo(a)pyrene 
250         
 1038 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1040 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1042 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    1045 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    1056 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    1061 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1062 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    1065 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
Average         1.4 0.9 0.0 0.0 0.0 0.0 0.1 2.4 0.05 0.03 4.25 2.75
± SEM                         0.01 0.01 0.80 0.65
 
Vehicle Control No Stressor 
 0         
 1029 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1030 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1031 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1044 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    1046 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1047 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1059 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1060 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.01 0.01 0.25 0.25
± SEM                         0.00 0.00 0.25 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation