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Study Information
Study Attribute Value
CEBS Accession Number: 002-01872-0022-0000-4
Chemical Name: Chloroprene
CASRN: 126-99-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A84892_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/15/1986 Bone Marrow 14 Male Mouse B6C3F1 Intraperitoneal Injection x 10/study, 14 days Negative

  Dose
(ppm)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical Chloroprene 
12         
 3982 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3990 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    3998 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4005 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4009 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4014 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4016 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4029 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.5 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.01 2.00 1.25
± SEM                         0.01 0.00 0.53 0.37
 
Test Chemical Chloroprene 
32         
 3974 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    3976 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    3984 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3994 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4007 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4010 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    4012 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4025 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.1 0.6 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.02 3.00 2.00
± SEM                         0.01 0.01 0.85 0.76
 
Test Chemical Chloroprene 
80         
 3971 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3977 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3979 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4000 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4011 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4013 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    4024 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4026 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.4 0.6 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 2.00 0.75
± SEM                         0.01 0.01 1.00 0.53
 
Vehicle Control No Stressor 
 0         
 3972 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3973 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3978 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3983 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3986 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3989 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3992 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3995 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4002 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4021 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4023 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.4 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 1.64 1.09
± SEM                         0.00 0.00 0.45 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation