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Study Information
Study Attribute Value
CEBS Accession Number: 002-02756-0029-0000-3
Chemical Name: Pyridine
CASRN: 110-86-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A86776_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/24/1993 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 368014 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    368099 50 2 1 0 0 0 1 0 4 0.08 0.06 6.00 4.00
    368100 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    368110 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    368134 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 2.00
    368161 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368162 50 1 4 0 1 0 0 0 6 0.12 0.02 10.00 2.00
    368171 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    368172 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    368195 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 1.9 0.0 0.1 0.0 0.1 0.0 3.4 0.07 0.03 5.50 2.25
± SEM                         0.01 0.01 1.05 0.45
 
Positive Control Mitomycin-C 
2         
 368011 50 2 4 0 0 0 1 0 7 0.14 0.06 10.00 4.00
    368026 50 8 4 0 0 0 1 0 13 0.26 0.18 22.00 14.00
    368033 50 6 6 0 0 0 1 0 13 0.26 0.14 16.00 8.00
    368041 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368065 50 8 5 0 0 0 1 0 14 0.28 0.18 24.00 16.00
    368104 50 2 5 0 0 0 2 0 9 0.18 0.08 16.00 8.00
    368129 50 7 3 1 2 0 2 0 15 0.30 0.20 18.00 14.00
    368157 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368173 50 4 3 0 0 0 1 0 8 0.16 0.10 14.00 10.00
    368178 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         4.8 3.9 0.1 0.3 0.0 1.1 0.0 10.1 0.20 0.12 15.50 9.50
± SEM                         0.03 0.02 2.26 1.76
 
Test Chemical Pyridine 
400         
 368002 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368004 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368008 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368030 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368038 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    368064 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368077 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368113 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368127 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    368183 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.01 0.25 0.50
± SEM                         0.01 0.01 0.25 0.50
 
Test Chemical Pyridine 
500         
 368003 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    368016 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
    368023 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368037 50 2 0 1 0 0 0 0 3 0.06 0.06 0.00 4.00
    368042 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368067 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368094 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    368124 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    368176 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368184 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
Average         0.9 0.9 0.1 0.0 0.0 0.0 0.0 1.9 0.04 0.02 1.50 1.75
± SEM                         0.01 0.01 0.98 0.59
 
Test Chemical Pyridine 
600         
 368006 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368009 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    368043 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368053 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368079 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368087 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    368088 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    368095 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368097 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368137 50 0 3 0 4 0 0 0 7 0.14 0.00 12.00 0.00
    368139 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368158 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    368165 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    368186 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368196 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 1.0 0.0 0.5 0.0 0.0 0.0 1.8 0.04 0.01 2.50 0.50
± SEM                         0.02 0.00 1.45 0.33
 
Vehicle Control No Stressor 
 0         
 368013 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368015 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368022 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    368027 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368056 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    368078 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368082 50 0 0 1 0 0 0 0 1 0.02 0.02 0.00 2.00
    368130 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368142 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    368188 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.5 0.01 0.01 0.75 0.50
± SEM                         0.01 0.00 0.53 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation