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Study Information
Study Attribute Value
CEBS Accession Number: 002-02756-0029-0000-3
Chemical Name: Pyridine
CASRN: 110-86-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A86776_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/22/1994 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 381015 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381034 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    381060 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    381069 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 4.00
    381073 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    381074 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    381086 50 4 2 0 1 0 0 0 7 0.14 0.08 10.00 8.00
    381093 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381094 50 2 3 0 0 0 0 0 5 0.10 0.04 6.00 2.00
    381107 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
Average         1.8 1.4 0.0 0.1 0.0 0.0 0.0 3.3 0.07 0.04 4.00 3.00
± SEM                         0.02 0.01 1.36 0.85
 
Positive Control Mitomycin-C 
2         
 381004 50 4 8 0 0 0 0 0 12 0.24 0.08 18.00 6.00
    381019 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    381025 50 1 2 1 0 0 0 1 5 0.10 0.06 10.00 6.00
    381031 50 5 1 0 1 0 1 5 13 0.26 0.22 20.00 20.00
    381036 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381041 50 7 5 0 0 0 0 0 12 0.24 0.14 16.00 10.00
    381044 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381052 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    381092 50 6 0 0 0 0 0 0 6 0.12 0.12 0.00 6.00
    381110 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
Average         3.0 2.6 0.1 0.1 0.0 0.1 0.8 6.8 0.14 0.08 9.25 6.25
± SEM                         0.04 0.03 2.88 2.31
 
Test Chemical Pyridine 
400         
 381003 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381006 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    381022 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    381032 50 1 0 1 0 0 0 0 2 0.04 0.04 0.00 4.00
    381039 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381050 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    381054 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381061 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    381080 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    381085 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.6 0.1 0.0 0.0 0.0 0.0 1.0 0.02 0.01 1.25 0.75
± SEM                         0.01 0.01 0.37 0.53
 
Test Chemical Pyridine 
500         
 381020 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    381030 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381035 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381038 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    381040 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381058 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    381078 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381079 50 2 0 1 0 0 0 0 3 0.06 0.06 0.00 6.00
    381083 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381098 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.4 0.1 0.0 0.0 0.0 0.0 1.1 0.02 0.02 1.00 1.50
± SEM                         0.01 0.01 0.65 0.82
 
Test Chemical Pyridine 
600         
 381008 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381010 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    381018 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381026 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    381051 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381065 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381066 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381067 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381070 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381076 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381084 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    381089 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    381090 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    381091 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381101 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.00 2.00 0.00
± SEM                         0.01 0.00 0.65 0.00
 
Vehicle Control No Stressor 
 0         
 381021 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381024 50 2 4 0 0 0 0 0 6 0.12 0.04 6.00 4.00
    381028 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381046 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    381055 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    381063 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    381064 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381071 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    381097 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    381100 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 1.1 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.02 3.00 1.50
± SEM                         0.02 0.01 1.07 0.63
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation