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Study Information
Study Attribute Value
CEBS Accession Number: 002-02359-0003-0000-4
Chemical Name: Lead sulfide
CASRN: 1314-87-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A89452_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/11/1992 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 310093 50 2 6 1 0 0 0 0 9 0.18 0.06 12.00 6.00
    310110 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310121 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310128 50 4 7 0 0 0 0 0 11 0.22 0.08 14.00 8.00
    310154 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    310164 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    310170 50 2 7 0 0 0 0 0 9 0.18 0.04 18.00 4.00
    310177 50 4 4 0 0 0 0 0 8 0.16 0.08 10.00 6.00
    310185 50 0 4 0 0 0 0 0 4 0.08 0.00 10.00 4.00
    310190 50 2 6 0 1 0 0 0 9 0.18 0.04 16.00 4.00
Average         2.1 4.8 0.1 0.1 0.0 0.0 0.0 7.1 0.14 0.05 11.75 4.75
± SEM                         0.02 0.01 1.44 0.65
 
Positive Control Dimethylbenzanthracene 
200         
 310101 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310106 50 6 6 1 0 0 2 0 15 0.30 0.18 24.00 16.00
    310114 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310120 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    310135 50 4 6 0 0 0 1 0 11 0.22 0.10 18.00 10.00
    310147 50 2 3 1 0 0 0 0 6 0.12 0.06 8.00 4.00
    310152 50 6 9 0 0 0 0 0 15 0.30 0.12 28.00 14.00
    310184 50 2 3 0 1 0 0 0 6 0.12 0.04 12.00 4.00
    310187 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    310191 50 2 6 2 0 0 0 0 10 0.20 0.08 14.00 6.00
Average         2.9 4.9 0.5 0.1 0.0 0.4 0.0 8.8 0.18 0.08 14.75 7.00
± SEM                         0.03 0.02 2.83 2.04
 
Test Chemical Lead sulfide 
500         
 310134 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310148 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310166 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    310169 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    310174 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    310176 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310178 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    310189 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310197 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310200 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.8 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.50 1.00
± SEM                         0.01 0.01 1.24 0.76
 
Test Chemical Lead sulfide 
1000         
 310105 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    310109 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310133 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310146 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310151 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310158 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310165 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310181 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    310192 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    310196 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
Average         0.4 1.0 0.0 0.0 0.0 0.0 0.0 1.4 0.03 0.01 2.75 0.75
± SEM                         0.01 0.01 1.19 0.53
 
Test Chemical Lead sulfide 
2000         
 310102 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    310104 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    310115 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310139 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310155 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    310161 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    310168 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310173 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    310193 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    310194 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         0.8 1.5 0.0 0.0 0.0 0.0 0.0 2.3 0.05 0.02 4.25 1.50
± SEM                         0.01 0.01 1.03 0.50
 
Test Chemical Lead sulfide 
3000         
 310111 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310116 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310119 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310149 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    310175 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310180 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    310182 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310183 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310186 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    310199 50 1 0 0 0 0 1 0 2 0.04 0.04 0.00 4.00
Average         0.4 0.3 0.0 0.0 0.0 0.1 0.0 0.8 0.02 0.01 0.75 1.00
± SEM                         0.01 0.01 0.53 0.53
 
Vehicle Control No Stressor 
 0         
 310107 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310122 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    310123 50 1 4 0 0 0 0 0 5 0.10 0.02 10.00 2.00
    310141 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310142 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    310143 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310171 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    310172 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    310188 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    310198 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
Average         0.5 1.3 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.01 2.75 1.00
± SEM                         0.01 0.00 1.25 0.38
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation