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Study Information
Study Attribute Value
CEBS Accession Number: 002-02359-0003-0000-4
Chemical Name: Lead sulfide
CASRN: 1314-87-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A89452_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/26/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 357026 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    357034 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357037 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357040 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    357050 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357080 50 2 1 0 0 0 0 0 3 0.06 0.04 8.00 6.00
    357087 50 3 4 0 0 0 0 0 7 0.14 0.06 14.00 6.00
    357161 50 0 0 1 0 0 0 0 1 0.02 0.02 0.00 4.00
    357171 50 2 4 0 0 0 1 0 7 0.14 0.06 18.00 10.00
    357174 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         1.4 1.5 0.1 0.0 0.0 0.1 0.0 3.1 0.06 0.03 6.00 4.25
± SEM                         0.02 0.01 2.42 1.10
 
Positive Control Dimethylbenzanthracene 
200         
 357002 50 4 4 0 0 0 0 0 8 0.16 0.08 16.00 8.00
    357052 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    357096 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    357097 50 6 3 0 0 0 4 2 15 0.30 0.24 24.00 20.00
    357112 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357128 50 3 4 1 0 0 0 1 9 0.18 0.10 16.00 10.00
    357145 50 5 2 0 0 0 0 0 7 0.14 0.10 10.00 8.00
    357158 50 1 0 0 0 0 0 1 2 0.04 0.04 0.00 4.00
    357175 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357179 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         2.9 2.5 0.1 0.0 0.0 0.5 0.5 6.5 0.13 0.08 11.00 7.25
± SEM                         0.03 0.03 2.62 2.10
 
Test Chemical Lead sulfide 
500         
 357035 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357054 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357074 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357085 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357088 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357091 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    357099 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357139 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357140 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357144 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.00 1.50 0.00
± SEM                         0.01 0.00 0.50 0.00
 
Test Chemical Lead sulfide 
1000         
 357021 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357059 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357083 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357095 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357102 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357146 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357154 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357162 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357164 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357167 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.01 0.00 0.50 0.00
± SEM                         0.00 0.00 0.33 0.00
 
Test Chemical Lead sulfide 
2000         
 357013 50 1 0 0 0 0 1 0 2 0.04 0.04 0.00 4.00
    357042 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357075 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357078 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357104 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    357141 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357143 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    357157 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357163 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357176 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.01 0.01 0.25 1.00
± SEM                         0.01 0.01 0.25 0.53
 
Test Chemical Lead sulfide 
3000         
 357012 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    357028 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357044 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357056 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357063 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357077 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357082 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357107 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357134 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357137 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.00 0.75 0.00
± SEM                         0.01 0.00 0.75 0.00
 
Vehicle Control No Stressor 
 0         
 357001 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    357006 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    357025 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357030 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    357045 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    357092 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357113 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357118 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    357153 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    357172 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.9 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.01 1.75 0.50
± SEM                         0.01 0.00 0.59 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation