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Study Information
Study Attribute Value
CEBS Accession Number: 002-01070-0013-0000-4
Chemical Name: 1,3-Butadiene
CASRN: 106-99-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A93093_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
02/06/1986 Bone Marrow 24 Male Mouse B6C3F1 Inhalation x 1/study, 24 hour Positive

  Dose
(ppm)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical 1,3-Butadiene 
6.25      
 3077 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3078 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3085 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    3090 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    3091 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3092 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    3093 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3094 50 1 1 0 0 0 1 0 3 0.06 0.04 6.00 4.00
    3111 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3116 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    3118 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.7 1.2 0.0 0.0 0.0 0.1 0.0 2.0 0.04 0.02 3.82 1.64
± SEM                         0.01 0.00 0.78 0.36
 
Test Chemical 1,3-Butadiene 
62.5       
 3072 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3074 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3079 50 3 1 0 0 0 0 0 4 0.08 0.06 10.00 8.00
    3080 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3082 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    3087 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    3088 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    3097 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3104 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.6 1.1 0.0 0.0 0.0 0.0 0.0 2.7 0.05 0.03 5.33 3.33
± SEM                         0.01 0.01 1.05 1.25
 
Test Chemical 1,3-Butadiene 
625         
 3073 50 4 4 0 0 0 2 0 10 0.20 0.12 14.00 8.00
    3076 50 3 1 0 0 1 0 1 6 0.12 0.10 10.00 8.00
    3086 50 6 6 0 0 0 1 0 13 0.26 0.14 22.00 14.00
    3089 50 6 0 1 0 1 1 1 10 0.20 0.20 12.00 12.00
    3095 50 4 2 2 0 0 0 0 8 0.16 0.12 16.00 12.00
    3098 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3099 50 7 2 1 0 0 1 0 11 0.22 0.18 14.00 12.00
    3101 50 1 1 0 0 0 0 1 3 0.06 0.04 6.00 4.00
    3106 50 11 3 1 0 0 0 0 15 0.30 0.24 24.00 24.00
    3107 50 3 0 1 0 0 0 0 4 0.08 0.08 8.00 8.00
    3109 50 6 3 2 0 0 0 0 11 0.22 0.16 24.00 18.00
    3117 50 26 4 4 0 0 0 1 35 0.70 0.62 44.00 44.00
Average         6.6 2.2 1.0 0.0 0.2 0.4 0.3 10.7 0.21 0.17 16.50 14.00
± SEM                         0.05 0.04 3.15 3.18
 
Vehicle Control No Stressor 
 0         
 3075 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3081 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3083 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    3084 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    3096 50 3 2 0 0 0 0 0 5 0.10 0.06 12.00 8.00
    3100 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    3102 50 0 2 1 0 0 0 0 3 0.06 0.02 6.00 2.00
    3103 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3105 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    3110 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 8.00
    3112 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3115 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.0 1.5 0.1 0.0 0.0 0.0 0.0 2.6 0.05 0.02 4.83 2.33
± SEM                         0.01 0.01 0.94 0.85
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation