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Clinical Chemistry Individual Animal

Study Information:

Chemical Name: Water Disinfection Byproducts (Dichloroacetic Acid)
CASRN: ="79-43-6"
Study Number: C96016
Study Length (Year Completed): 13 Weeks (N/A)
Exposure Route: WATER
TDMS Number: 9601601.fixtime
Sex: Female
Strain and Species: Fischer 344 Rats

Clinical Chemistry Individual Animal Data
Measurement Time Animal Number Dose Group (mg/L) Control Code BUN (mg_dL) Creat (U per L) TP (g_dL) ALB (g_dL) Creat Kinase (IU_L) ALT (IU_L) SDH (IU_L) ALP (IU_L) TBA (umol per g)
Day 3 0181 0 U 14.8 0.4 5.9 4.1 146 64 12 629 28.5
Day 3 0182 0 U 15.5 0.5 5.7 3.7 434 59 3 629 28.3
Day 3 0183 0 U 14.8 0.5 6.3 4.3 101 47 13 578 20.4
Day 3 0184 0 U 16.5 0.5 5.7 4.0 183 56 10 591 27.8
Day 3 0185 0 U 14.4 0.5 6.2 4.2 106 47 12 556 18.5
Day 3 0186 0 U 15.7 0.4 5.8 4.0 158 55 10 500 15.4
Day 3 0187 0 U 18.3 0.5 6.1 4.1 235 54 7 540 18.5
Day 3 0188 0 U 15.0 0.5 6.3 4.2 15.2 54 0 534
Day 3 0189 0 U 14.9 0.5 6.1 4.1 116 66 8 677 15.2
Day 3 0190 0 U 15.0 0.5 5.6 3.9 163 77 12 646 40.3
Day 3 0191 67 15.4 0.5 5.7 3.9 543 54 5 577 25.0
Day 3 0192 67 16.9 0.5 5.9 4.2 214 57 7 524 22.4
Day 3 0193 67 15.2 0.5 5.7 3.9 104 59 12 562 26.2
Day 3 0194 67 19.8 0.5 6.2 4.3 219 55 8 567 19.8
Day 3 0195 67 13.3 0.5 5.5 3.7 145 53 7 599 26.3
Day 3 0196 67 14.7 0.4 5.9 4.0 106 51 11 516 36.2
Day 3 0197 67 13.2 0.4 6.0 4.0 301 60 4 616 17.5
Day 3 0198 67 12.8 0.4 6.2 4.1 168 46 6 510 23.8
Day 3 0199 67 13.9 0.4 6.3 4.2 97 54 9 539 21.7
Day 3 0200 67 14.8 0.5 6.1 4.1 241 66 7 681 23.9
Day 3 0201 125 15.6 0.4 5.4 3.6 335 60 6 533 21.7
Day 3 0202 125 16.3 0.5 6.2 4.2 178 50 9 564 16.7
Day 3 0203 125 15.6 0.4 5.9 4.0 190 64 6 609 19.0
Day 3 0204 125 18.9 0.4 6.2 4.3 123 60 7 602 21.8
Day 3 0205 125 15.2 0.5 5.5 3.7 246 61 8 729 19.0
Day 3 0206 125 13.8 0.5 5.6 3.8 625 75 5 663 29.8
Day 3 0207 125 12.9 0.4 5.9 4.0 123 62 7 584 17.8
Day 3 0208 125 14.3 0.5 5.9 4.0 117 60 9 608 28.6
Day 3 0209 125 13.5 0.5 5.9 4.1 232 55 7 561 19.9
Day 3 0210 125 10.8 0.4 5.7 3.9 137 48 9 555 17.8
Day 3 0211 250 15.5 0.5 6.0 4.0 263 46 10 512 16.8
Day 3 0212 250 15.4 0.5 5.8 4.0 159 60 9 633 21.8
Day 3 0213 250 13.8 0.4 5.7 3.9 236 58 6 632 23.6
Day 3 0214 250 14.3 0.4 6.0 4.1 174 51 5 519 19.7
Day 3 0215 250 19.9 0.5 6.3 4.3 178 59 8 539 16.9
Day 3 0216 250 15.1 0.5 6.0 2.5 89 63 6 630 24.5
Day 3 0217 250 11.7 0.4 5.9 4.0 177 47 5 577 19.9
Day 3 0218 250 15.4 0.4 5.9 4.0 214 63 5 628 13.7
Day 3 0219 250 10.6 0.4 5.4 3.7 187 68 5 691 18.1
Day 3 0220 250 16.1 0.5 6.0 4.1 418 52 6 547 13.8
Day 3 0221 500 12.5 0.4 5.3 3.6 221 53 5 530 27.0
Day 3 0222 500 16.4 0.4 6.0 4.1 195 47 5 519 19.2
Day 3 0223 500 14.2 0.5 6.1 4.1 365 40 5 555 15.0
Day 3 0224 500 15.9 0.5 5.6 3.9 148 56 6 563 34.4
Day 3 0225 500 11.4 0.4 5.6 3.8 266 63 5 622 34.9
Day 3 0226 500 12.5 0.5 5.5 3.8 315 53 4 547 22.0
Day 3 0227 500 13.8 0.4 5.8 4.0 350 65 4 627 17.3
Day 3 0228 500 13.2 0.4 5.7 3.9 164 52 7 489 20.6
Day 3 0229 500 14.9 0.4 6.0 4.1 152 50 8 500 18.6
Day 3 0230 500 13.2 0.4 5.9 4.0 495 67 6 596 21.6
Day 3 0231 1000 13.4 0.4 5.5 3.9 206 49 6 486 15.0
Day 3 0232 1000 13.2 0.5 5.7 4.0 211 54 5 506 18.4
Day 3 0233 1000 14.9 0.4 5.7 3.9 251 59 6 547 20.2
Day 3 0234 1000 12.3 0.4 5.4 3.8 152 63 7 627 18.3
Day 3 0235 1000 10.8 0.5 5.8 4.0 190 61 7 606 14.3
Day 3 0236 1000 14.6 0.5 5.4 3.8 286 61 4 552 28.4
Day 3 0237 1000 14.6 0.4 5.6 3.9 233 69 4 684 36.8
Day 3 0238 1000 11.7 0.4 5.3 3.8 272 83 5 646 13.8
Day 3 0239 1000 14.8 0.4 5.8 4.0 294 65 5 526 24.3
Day 3 0240 1000 11.6 0.4 5.3 3.7 292 69 5 526 28.8
Day 21 0181 0 U 19.8 0.5 6.3 4.3 233 50 9 428 19.3
Day 21 0182 0 U 19.3 0.5 6.1 4.1 324 39 7 392 16.6
Day 21 0183 0 U 16.6 0.5 6.4 4.3 137 37 12 346 24.0
Day 21 0184 0 U 21.0* 0.5 5.7 4.0 167 42 11 386 18.2
Day 21 0185 0 U 18.9 0.6 6.2 4.2 258 42 9 360 13.7
Day 21 0186 0 U 15.2 0.5 6.2 4.1 179 41 10 351 21.9
Day 21 0187 0 U 16.0 0.4 6.1 4.1 233 41 7 376 16.8
Day 21 0188 0 U 17.4 0.5 6.1 4.1 436 46 4 360 19.5
Day 21 0189 0 U 18.6 0.5 5.8 3.9 235 38 7 374 15.2
Day 21 0190 0 U 17.7 0.5 6.5 4.4 362 50 13 424 22.5
Day 21 0191 67 18.5 0.5 6.1 4.1 324 45 10 362 21.8
Day 21 0192 67 15.4 0.5 6.1 4.1 227 38 7 322 21.4
Day 21 0193 67 17.5 0.4 6.2 4.3 139 38 12 409 21.9
Day 21 0194 67 18.2 0.4 6.1 4.1 334 36 8 336 12.7
Day 21 0195 67 18.8 0.5 6.3 4.3 233 35 8 361 14.2
Day 21 0196 67 16.4 0.5 6.3 4.2 166 39 10 319 26.4
Day 21 0197 67 15.4 0.5 6.3 4.3 162 37 9 397 11.8
Day 21 0198 67 14.9 0.4 6.3 4.2 434 39 6 318 14.3
Day 21 0199 67 14.6 0.5 6.2 4.1 205 41 9 336 17.0
Day 21 0201 125 16.6 0.5 5.7 3.8 267 43 7 365 15.7
Day 21 0202 125 16.8 0.5 6.4 4.3 185 36 12 319 17.2
Day 21 0203 125 16.4 0.5 6.2 4.3 139 41 10 360 17.9
Day 21 0204 125 16.6 0.5 6.2 4.2 231 32 6 381 9.1
Day 21 0205 125 18.3 0.4 6.1 4.1 298 39 5 407 13.2
Day 21 0206 125 17.2 0.4 5.7 3.9 193 40 8 401 21.9
Day 21 0207 125 15.8 0.4 6.2 4.1 417 37 6 381 18.1
Day 21 0208 125 15.8 0.5 6.0 4.0 212 39 10 358 16.7
Day 21 0209 125 15.9 0.5 6.3 4.3 188 40 9 389 19.5
Day 21 0210 125 16.8 0.5 6.3 4.4 201 37 13 340 16.9
Day 21 0211 250 17.6 0.5 6.1 1.2* 1076 44 8 347 29.9
Day 21 0212 250 17.4 0.4 6.0 4.1 294 41 7 390 14.9
Day 21 0213 250 16.5 0.5 6.3 4.3 236 38 9 397 14.4
Day 21 0214 250 17.1 0.5 6.1 4.1 188 34 9 334 20.8
Day 21 0215 250 14.2 0.5 6.2 4.3 270 35 5 308 21.8
Day 21 0216 250 16.4 0.4 5.6 4.0 323 34 7 356 15.1
Day 21 0217 250 13.5 0.4 6.0 4.1 385 38 5 344 11.2
Day 21 0218 250 15.6 0.4 6.1 4.2 282 35 6 377 12.7
Day 21 0219 250 16.2 0.5 6.4 4.4 191 43 9 422 13.1
Day 21 0220 250 15.8 0.5 6.0 4.1 222 38 11 348 17.1
Day 21 0221 500 18.0 0.4 5.7 4.1 249 35 6 312 22.5
Day 21 0222 500 16.4 0.5 6.2 4.4 221 36 8 336 26.5
Day 21 0223 500 13.8 0.4 6.1 4.3 135 33 10 341 10.7
Day 21 0224 500 15.2 0.5 5.9 4.1 193 37 7 387 21.5
Day 21 0225 500 14.0 0.4 6.0 4.2 351 37 5 384 20.6
Day 21 0226 500 14.7 0.5 5.9 4.0 237 32 6 335 31.8
Day 21 0227 500 14.6 0.4 6.0 4.1 231 36 6 378 21.1
Day 21 0228 500 16.0 0.4 5.9 4.1 585 38 6 344 14.8
Day 21 0229 500 15.0 0.5 6.3 4.4 389 39 4 318 22.5
Day 21 0230 500 14.1 0.4 6.1 4.2 179 37 11 399 24.0
Day 21 0231 1000 14.5 0.4 6.2 4.5 327 33 6 337 32.8
Day 21 0232 1000 15.4 0.6 6.5 4.8* 405 36 6 380 28.6
Day 21 0233 1000 16.3 0.4 6.4 4.6 301 44 6 398 31.0
Day 21 0234 1000 14.5 0.4 6.2 4.4 211 35 8 404 18.8
Day 21 0235 1000 13.0 0.4 6.3 4.5 294 39 6 351 19.5
Day 21 0236 1000 16.2 0.5 6.6 4.8* 250 45 9 389 35.1
Day 21 0237 1000 15.7 0.4 6.2 4.4 430 40 6 395 25.6
Day 21 0238 1000 14.3 0.5 6.4 4.6 627 47 7 436 21.0
Day 21 0239 1000 15.2 0.4 6.4 4.5 225 43 10 390 35.1
Day 21 0240 1000 14.5 0.4 6.4 4.6 322 54 7 383 26.3
Day 92 0061 0 U 17.7 0.6 7.0 4.8 103 124 15 192 28.9
Day 92 0062 0 U 15.1 0.5 6.3 4.4 97 68 19 154 27.0
Day 92 0063 0 U 14.4 0.6 6.6 4.5 164 149 28 162 33.5
Day 92 0064 0 U 13.9 0.6 7.4 4.9* 155 134 31 160 20.0
Day 92 0065 0 U 14.2 0.0* 6.6 0.0* 119 58 14 170 34.3
Day 92 0066 0 U 13.8 0.5 6.3 4.3 212 86 12 152 43.6
Day 92 0067 0 U 14.9 0.5 6.0 4.1 125 53 13 155 21.0
Day 92 0068 0 U 12.2 0.5 6.1 4.2 81 40 12 149 18.4
Day 92 0069 0 U 12.8 0.5 6.6 4.4 318 161 28 162 16.4
Day 92 0070 0 U 14.5 0.6 6.6 4.4 265 39 9 134 19.0
Day 92 0071 67 18.1 0.5 6.1 4.3 142 101 21 194 22.0
Day 92 0072 67 17.6 0.5 6.5 4.5 123 158 27 151 71.8
Day 92 0073 67 0.0* 0.0* 0.0* 0.0* 44.6 59 0 179
Day 92 0074 67 14.7 0.5 6.8 4.7 228 168 28 165 31.2
Day 92 0075 67 16.1 0.5 6.4 4.6 93 156 29 130 58.1
Day 92 0076 67 15.4 0.5 6.2 4.2 365 93 16 148 41.2
Day 92 0077 67 14.4 0.6 7.1 5.0* 183 78 13 161 21.8
Day 92 0078 67 14.2 0.5 6.4 4.5 196 73 19 150 37.5
Day 92 0079 67 13.2 0.5 6.6 4.4 102 90 23 176 13.0
Day 92 0080 67 15.6 0.5 7.2 4.9* 115 95 24 122 15.5
Day 92 0081 125 17.8 0.6 6.8 4.5 141 77 18 160 45.0
Day 92 0082 125 16.1 0.5 6.7 4.3 134 94 21 192 27.8
Day 92 0083 125 18.5 0.6 7.2 4.8 188 154 26 190 43.4
Day 92 0084 125 15.9 0.5 7.5 0.0* 133 63 17 168 22.8
Day 92 0085 125 0.0* 0.0* 0.0* 0.0* 214 119 14 181 33.5
Day 92 0086 125 13.6 0.5 6.0 4.1 234 69 12 152 47.0
Day 92 0087 125 15.1 0.6 6.7 4.6 125 71 15 153 27.0
Day 92 0088 125 12.5 0.5 6.4 4.3 319 37 11 108 28.0
Day 92 0089 125 13.4 0.5 6.6 4.5 118 89 19 132 14.2
Day 92 0090 125 14.5 0.6 6.6 4.5 120 95 21 110 14.1
Day 92 0091 250 14.4 0.6 6.8 4.8 600 76 13 150 36.0
Day 92 0092 250 17.2 0.5 6.8 4.8 107 62 17 176 13.1
Day 92 0093 250 13.4 0.5 6.5 4.5 133 38 11 157 26.3
Day 92 0094 250 0.0* 0.0* 6.1 4.4 224 44 6 189 26.7
Day 92 0095 250 13.5 0.5 6.5 4.4 341 58 12 153 27.6
Day 92 0096 250 13.5 0.5 6.6 4.7 352 58 11 161 28.7
Day 92 0097 250 14.0 0.6 6.9 4.8 126 48 16 152 20.7
Day 92 0098 250 12.6 0.5 7.2 4.9 95 41 17 139 23.5
Day 92 0099 250 13.4 0.6 7.2 4.9 195 48 19 154 11.7
Day 92 0100 250 14.5 0.5 7.0 4.7 136 52 16 152 15.3
Day 92 0101 500 16.2 0.6 6.7 4.7 336 71 12 178 19.6
Day 92 0102 500 12.9 0.5 6.1 4.3 259 105 17 161 37.6
Day 92 0103 500 15.7 0.5 6.6 4.6 136 58 10 155 29.5
Day 92 0104 500 14.2 0.6 6.2 4.5 147 51 10 156 26.4
Day 92 0105 500 11.6 0.5 6.7 4.8 204 42 9 156 12.4
Day 92 0106 500 12.3 0.5 6.7 4.8 150 40 8 131 28.8
Day 92 0107 500 13.1 0.5 6.3 4.5 260 52 10 146 31.2
Day 92 0108 500 13.3 0.5 6.8 4.6 239 46 13 142 24.5
Day 92 0109 500 10.5 0.4 6.1 4.2 163 42 10 142 15.8
Day 92 0110 500 17.0 0.5 7.1 4.9 277 68 16 114 18.4
Day 92 0111 1000 15.6 0.5 6.4 4.7 139 40 10 203 16.9
Day 92 0112 1000 15.8 0.6 6.3 4.7 100 46 13 175 39.6
Day 92 0113 1000 14.8 0.5 6.1 4.6 93 49 11 177 32.5
Day 92 0114 1000 14.3 0.5 6.1 4.6 365 53 9 178 26.2
Day 92 0115 1000 12.7 0.5 6.8 5.0 261 47 8 170 16.6
Day 92 0116 1000 12.2 0.5 5.9 4.4 109 47 10 149 19.9
Day 92 0117 1000 13.2 0.5 6.0 4.3 67 43 10 161 17.2
Day 92 0118 1000 13.4 0.5 6.4 4.5 151 39 11 141 10.9
Day 92 0119 1000 15.5 0.6 6.5 4.7 91 46 14 151 27.3
Day 92 0120 1000 12.8 0.5 6.2 4.4 63 45 10 140 13.5
Abbreviations:
NA: Not Available, U: Untreated Control, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, ALP: Alkaline Phosphatase, TBA: Bile Acids Per G Tissue