If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Clinical Chemistry Individual Animal

Study Information:

Chemical Name: Water Disinfection Byproducts (Dichloroacetic Acid)
CASRN: ="79-43-6"
Study Number: C96016
Study Length (Year Completed): 13 Weeks (N/A)
Exposure Route: WATER
TDMS Number: 9601601.fixtime
Sex: Male
Strain and Species: Fischer 344 Rats

Clinical Chemistry Individual Animal Data
Measurement Time Animal Number Dose Group (mg/L) Control Code BUN (mg_dL) Creat (U per L) TP (g_dL) ALB (g_dL) Creat Kinase (IU_L) ALT (IU_L) SDH (IU_L) ALP (IU_L) TBA (umol per g)
Day 3 0121 0 U 16.6 0.5 5.8 3.9 224 53 7 665 19.1
Day 3 0122 0 U 15.4 0.5 5.5 3.7 369 75 4 798 18.4
Day 3 0123 0 U 13.8 0.5 5.9 3.9 224 65 8 713 35.4
Day 3 0124 0 U 14.0 0.5 5.4 3.7 338 78 8 739 49.2
Day 3 0125 0 U 12.9 0.5 5.5 3.7 288 76 4 734 50.9
Day 3 0126 0 U 15.5 0.5 5.7 3.8 268 61 7 681 17.9
Day 3 0127 0 U 15.9 0.5 5.7 3.7 185 58 10 655 16.1
Day 3 0128 0 U 15.7 0.5 5.6 3.7 320 69 6 610 15.8
Day 3 0129 0 U 14.3 0.5 5.9 3.9 268 54 7 717 16.8
Day 3 0130 0 U 15.8 0.5 5.5 3.8 288 67 8 721 17.7
Day 3 0131 67 15.5 0.5 5.4 3.6 265 82 6 744 44.7
Day 3 0132 67 14.7 0.5 5.9 4.0 168 60 12 666 23.2
Day 3 0133 67 12.3 0.5 5.5 3.7 291 67 6 728 34.4
Day 3 0134 67 14.0 0.5 5.3 3.6 432 76 8 845 43.4
Day 3 0135 67 13.0 0.5 6.1 4.0 223 48 9 629 28.1
Day 3 0136 67 15.5 0.4 5.4 3.6 279 68 9 765 29.8
Day 3 0137 67 15.2 0.5 5.6 3.8 292 68 6 742 34.7
Day 3 0138 67 13.3 0.5 5.9 3.9 232 60 8 631 26.0
Day 3 0139 67 13.3 0.4 5.4 3.6 331 74 8 754 29.7
Day 3 0140 67 14.2 0.5 6.0 4.0 387 49 9 611 14.8
Day 3 0141 125 14.9 0.5 6.0 4.0 292 48 8 575 31.2
Day 3 0142 125 15.6 0.5 5.5 3.7 333 82 9 762 31.7
Day 3 0143 125 13.1 0.5 5.4 3.6 306 73 7 796 30.5
Day 3 0144 125 14.6 0.5 6.2 4.1 385 56 8 651 17.8
Day 3 0145 125 15.4 0.5 5.8 3.9 180 64 8 661 21.4
Day 3 0146 125 15.5 0.4 5.1 3.5 197 67 7 746 43.2
Day 3 0147 125 13.1 0.4 5.8 3.8 250 70 8 755 30.0
Day 3 0148 125 14.4 0.5 5.4 3.6 480 68 5 684 43.5
Day 3 0149 125 14.4 0.5 6.0 4.0 320 58 6 713 22.2
Day 3 0150 125 14.3 0.5 6.1 4.0 250 52 12 612 35.5
Day 3 0151 250 18.2 0.5 5.6 3.9 313 64 7 651 32.4
Day 3 0152 250 17.4 0.5 5.6 3.8 332 69 9 695 16.0
Day 3 0153 250 17.1 0.5 5.7 3.8 353 71 6 743 35.6
Day 3 0154 250 13.6 0.5 5.9 3.9 521 70 5 674 29.6
Day 3 0155 250 12.1 0.5 5.8 3.9 383 58 5 599 23.7
Day 3 0156 250 14.1 0.4 5.2 3.5 422 71 3 760 52.2
Day 3 0157 250 15.8 0.5 6.1 4.1 231 66 6 764 17.6
Day 3 0158 250 14.4 0.5 6.1 4.1 255 50 7 652 13.2
Day 3 0159 250 17.1 0.5 5.3 3.5 354 73 5 735 22.8
Day 3 0160 250 12.8 0.4 5.4 3.6 300 82 7 778 44.8
Day 3 0161 500 16.8 0.5 5.1 3.5 496 66 5 786 17.9
Day 3 0162 500 14.0 0.5 5.8 3.9 329 75 6 701 28.5
Day 3 0163 500 14.4 0.5 5.4 3.6 294 67 5 788 30.3
Day 3 0164 500 16.6 0.5 5.8 3.8 291 57 6 623 34.1
Day 3 0165 500 16.8 0.5 5.9 4.0 359 58 5 571 23.7
Day 3 0166 500 16.2 0.5 5.4 3.7 287 70 7 681 28.1
Day 3 0167 500 14.4 0.5 5.1 3.4 473 82 5 881 32.0
Day 3 0168 500 14.0 0.5 6.1 4.0 479 64 5 685 20.8
Day 3 0169 500 16.5 0.5 5.4 3.7 313 80 6 774 35.6
Day 3 0170 500 16.5 0.5 6.1 4.0 240 58 8 735 16.8
Day 3 0171 1000 14.4 0.5 5.5 3.8 388 55 5 665 12.8
Day 3 0172 1000 13.7 0.5 5.9 4.0 276 62 6 677 19.8
Day 3 0173 1000 16.2 0.5 5.2 3.5 371 81 5 723 33.1
Day 3 0174 1000 16.2 0.5 5.3 3.6 617 84 6 795 19.2
Day 3 0175 1000 13.8 0.5 5.4 3.7 452 75 4 686 19.8
Day 3 0176 1000 12.2 0.5 4.8 3.3 470 69 5 678 34.7
Day 3 0177 1000 13.7 0.5 5.3 3.7 392 87 5 752 37.4
Day 3 0178 1000 17.0 0.5 5.7 3.8 363 48 5 598 17.1
Day 3 0179 1000 17.4 0.5 5.9 4.0 392 64 4 621 21.6
Day 3 0180 1000 15.2 0.5 5.6 3.7 288 73 4 726 32.5
Day 21 0121 0 U 17.6 0.6 6.0 3.9 887 39 3 434 27.7
Day 21 0122 0 U 15.5 0.6 6.4 4.2 358 45 8 508 19.2
Day 21 0123 0 U 15.5 0.6 6.5 4.2 222 49 10 527 22.6
Day 21 0124 0 U 13.5 0.6 6.2 4.1 244 48 7 515 30.0
Day 21 0125 0 U 15.3 0.6 6.2 4.2 307 44 9 537 27.2
Day 21 0126 0 U 17.2 0.6 6.4 4.4 282 45 5 498 29.9
Day 21 0127 0 U 15.8 0.6 6.3 4.0 635 51 7 485 18.0
Day 21 0128 0 U 15.5 0.5 6.3 4.1 304 52 5 461 24.5
Day 21 0129 0 U 17.2 0.6 6.3 4.1 352 46 8 440 14.9
Day 21 0130 0 U 19.8 0.6 6.5 4.3 369 55 8 485 25.1
Day 21 0131 67 13.4 0.6 6.5 4.3 460 48 7 570 36.8
Day 21 0132 67 14.7 0.6 6.4 4.3 665 52 14 479 30.8
Day 21 0133 67 15.1 0.6 6.6 4.4 299 46 9 520 33.3
Day 21 0134 67 14.3 0.6 6.1 4.0 507 43 6 533 18.6
Day 21 0135 67 15.5 0.5 6.3 4.2 284 41 10 437 18.7
Day 21 0136 67 15.1 0.5 6.2 4.0 300 50 7 502 33.9
Day 21 0137 67 17.1 0.6 6.8 4.5 422 51 8 530 14.6
Day 21 0138 67 17.3 0.5 6.7 4.4 1075 58 8 436 22.6
Day 21 0139 67 15.3 0.5 6.2 4.0 1292 54 6 488 21.4
Day 21 0140 67 15.7 0.6 6.1 4.0 515 45 6 399 13.7
Day 21 0141 125 14.5 0.6 6.3 4.3 219 47 12 429 15.9
Day 21 0142 125 15.4 0.5 6.3 4.1 334 49 7 535 21.8
Day 21 0143 125 14.7 0.6 6.4 4.3 543 48 5 565 26.2
Day 21 0144 125 15.0 0.6 6.2 4.1 330 48 8 439 24.0
Day 21 0145 125 13.4 0.6 6.2 4.1 208 47 10 471 23.3
Day 21 0146 125 13.5 0.6 6.5 4.2 337 51 9 520 43.9
Day 21 0147 125 15.6 0.5 6.3 4.1 1010 49 8 464 29.6
Day 21 0148 125 15.8 0.5 6.6 4.4 310 50 10 557 22.5
Day 21 0149 125 16.7 0.6 6.7 4.4 305 48 9 479 21.3
Day 21 0150 125 13.6 0.6 6.6 4.3 1122 47 8 433 21.5
Day 21 0151 250 14.7 0.5 6.0 4.0 506 42 7 496 25.6
Day 21 0152 250 14.4 0.5 6.0 4.1 424 48 8 531 16.5
Day 21 0153 250 13.4 0.6 6.2 4.2 247 45 10 482 19.4
Day 21 0154 250 11.7 0.6 6.4 4.2 318 50 7 543 31.5
Day 21 0155 250 12.1 0.6 6.3 4.1 368 41 6 493 20.8
Day 21 0156 250 16.1 0.5 6.2 4.1 304 46 6 469 26.0
Day 21 0157 250 14.2 0.6 6.2 4.1 367 51 7 489 17.4
Day 21 0158 250 15.7 0.5 6.3 4.3 273 45 8 413 21.8
Day 21 0159 250 13.7 0.6 6.1 3.9 537 51 5 496 24.7
Day 21 0160 250 14.3 0.6 6.4 4.2 346 53 7 491 21.7
Day 21 0161 500 17.3 0.5 5.8 4.1 731 46 7 475 15.3
Day 21 0162 500 12.9 0.6 6.3 4.3 701 54 10 524 47.6
Day 21 0163 500 15.5 0.6 6.5 4.3 437 47 7 515 21.1
Day 21 0164 500 13.6 0.6 6.5 4.4 491 48 6 525 38.4
Day 21 0165 500 14.4 0.6 6.1 4.2 551 50 7 486 25.2
Day 21 0166 500 13.7 0.5 5.8 4.0 336 46 6 552 28.6
Day 21 0167 500 13.9 0.5 6.5 4.4 283 54 6 574 24.6
Day 21 0168 500 11.6 0.6 6.9 4.5 1164 50 6 541 30.2
Day 21 0169 500 13.7 0.6 6.2 4.2 519 44 6 527 23.6
Day 21 0170 500 15.2 0.5 6.5 4.3 582 48 6 490 23.8
Day 21 0171 1000 15.2 0.6 6.5 4.5 838 45 7 467 21.0
Day 21 0172 1000 13.8 0.6 6.5 4.5 407 43 6 472 38.2
Day 21 0173 1000 14.0 0.6 6.4 4.4 662 48 6 590 45.7
Day 21 0174 1000 15.8 0.5 6.1 4.3 364 47 6 498 42.0
Day 21 0175 1000 14.6 0.6 6.2 4.4 685 51 7 508 33.2
Day 21 0176 1000 12.1 0.5 5.8 4.1 465 43 6 575 40.4
Day 21 0177 1000 14.5 0.6 6.6 4.6 804 52 5 589 30.6
Day 21 0178 1000 14.5 0.6 6.2 4.4 514 41 5 518 23.0
Day 21 0179 1000 15.1 0.6 6.5 4.4 407 45 5 468 27.3
Day 21 0180 1000 11.2 0.6 6.3 4.3 377 50 6 558 67.9
Day 92 0001 0 U 23.5 0.7 6.7 4.4 372 95 13 167 20.9
Day 92 0002 0 U 25.3 0.6 6.6 4.4 236 140 20 172 32.9
Day 92 0003 0 U 27.7 0.7 6.1 4.3 226 80 19 168 30.4
Day 92 0004 0 U 22.1 0.6 6.5 4.5 192 118 24 165 23.9
Day 92 0005 0 U 26.7 0.6 7.3 5.2 271 375 47 187 40.0
Day 92 0006 0 U 18.2 0.6 6.5 4.4 296 182 28 215 29.4
Day 92 0007 0 U 18.7 0.5 6.5 4.4 142 164 33 177 33.3
Day 92 0008 0 U 18.4 0.7 6.9 4.6 126 198 41 203 22.1
Day 92 0009 0 U 16.6 0.6 6.5 4.3 311 157 21 184 27.9
Day 92 0010 0 U 15.7 0.7 6.3 4.1 341 159 23 180 35.8
Day 92 0011 67 18.0 0.7 6.6 4.3 286 118 20 196 45.7
Day 92 0012 67 17.0 0.7 6.2 4.0 246 117 22 198 26.7
Day 92 0013 67 19.1 0.6 6.3 4.2 194 155 28 210 21.1
Day 92 0014 67 16.4 0.6 6.4 4.2 137 105 23 193 25.5
Day 92 0015 67 16.5 0.7 6.6 4.4 214 99 19 213 24.6
Day 92 0016 67 21.9 0.6 6.4 4.6 288 57 16 154 20.2
Day 92 0017 67 23.5 0.7 6.7 4.5 105 152 30 171 30.1
Day 92 0018 67 26.4 0.7 6.4 4.4 375 316 25 182 29.6
Day 92 0019 67 23.4 0.5 6.5 4.5 385 126 19 192 19.3
Day 92 0020 67 21.8 0.6 6.5 4.5 203 121 20 180 27.4
Day 92 0021 125 22.3 0.7 6.7 4.4 201 156 22 186 23.6
Day 92 0022 125 20.6 0.7 6.5 4.3 177 68 18 183 23.7
Day 92 0023 125 20.6 0.6 6.1 4.2 201 105 4 160 56.6
Day 92 0024 125 21.9 0.6 6.8 4.6 288 125 23 200 26.5
Day 92 0025 125 21.9 0.7 6.5 4.3 606 154 29 196 31.6
Day 92 0026 125 18.1 0.6 6.5 4.3 407 86 17 189 19.5
Day 92 0027 125 16.3 0.6 6.9 4.3 260 134 27 225 22.7
Day 92 0028 125 18.3 0.7 6.9 4.5 597 244 44 195 33.3
Day 92 0029 125 17.1 0.7 6.9 4.4 358 218 28 200 23.5
Day 92 0030 125 16.8 0.6 6.7 4.4 284 134 34 191 31.0
Day 92 0031 250 22.0 0.6 6.7 4.2 281 115 18 182 36.0
Day 92 0032 250 17.9 0.7 6.7 4.3 170 66 15 155 34.2
Day 92 0033 250 19.2 0.6 6.3 4.3 144 107 24 154 36.6
Day 92 0034 250 21.9 0.6 6.9 4.5 243 229 40 187 38.5
Day 92 0035 250 19.3 0.6 6.5 4.2 232 139 25 163 27.1
Day 92 0036 250 0.0* 0.0* 0.0* 0.0* 348 181 26 164 28.9
Day 92 0037 250 26.8 0.7 7.1 4.6 307 91 22 161 23.0
Day 92 0038 250 26.5 0.6 6.8 4.6 688 102 19 146 32.3
Day 92 0039 250 25.4 0.6 6.7 4.6 400 80 15 151 20.1
Day 92 0040 250 28.0 0.6 7.2 5.1 266 187 39 180 38.5
Day 92 0041 500 16.4 0.6 6.3 4.3 358 69 11 214 19.7
Day 92 0042 500 21.2 0.7 6.6 4.5 211 96 18 189 46.4
Day 92 0043 500 17.2 0.6 6.1 4.0 449 69 15 167 28.9
Day 92 0044 500 16.5 0.6 6.6 4.5 314 114 23 186 38.5
Day 92 0045 500 17.2 0.7 6.2 4.2 251 98 24 200 21.1
Day 92 0046 500 22.0 0.7 6.7 4.6 368 112 22 162 29.3
Day 92 0047 500 25.7 0.6 6.9 4.7 222 74 21 171 24.8
Day 92 0048 500 21.1 0.6 6.7 4.8 361 80 14 192 20.1
Day 92 0049 500 22.6 0.6 6.6 4.7 335 63 14 157 19.0
Day 92 0050 500 22.2 0.6 6.6 4.8 203 120 24 166 19.7
Day 92 0051 1000 19.0 0.6 6.4 4.4 246 66 11 184 29.8
Day 92 0052 1000 15.8 0.6 6.1 4.3 314 58 11 189 54.0
Day 92 0053 1000 15.3 0.6 6.0 4.2 370 46 8 190 29.5
Day 92 0054 1000 17.0 0.6 6.7 4.7 179 65 13 210 22.6
Day 92 0055 1000 15.4 0.6 6.4 4.5 149 73 21 194 36.8
Day 92 0056 1000 15.4 0.6 6.4 4.6 201 79 17 195 50.7
Day 92 0057 1000 18.7 0.6 6.7 4.5 183 85 15 239 16.3
Day 92 0058 1000 16.2 0.6 6.4 4.4 392 79 13 167 35.3
Day 92 0059 1000 14.5 0.5 6.5 4.5 350 74 11 169 19.1
Day 92 0060 1000 13.1 0.6 6.4 4.6 146 102 19 187 44.4
Abbreviations:
NA: Not Available, U: Untreated Control, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, ALP: Alkaline Phosphatase, TBA: Bile Acids Per G Tissue