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Clinical Chemistry Individual Animal

Study Information:

Chemical Name: Oxymetholone
CASRN: ="434-07-1"
Study Number: C88032B
Study Length (Year Completed): 13 Weeks (N/A)
Exposure Route: GAV
TDMS Number: 8803203.ss
Sex: Female
Strain and Species: Fischer 344 Rats

Clinical Chemistry Individual Animal Data
Measurement Time Animal Number Dose Group (mg/kg) Control Code Creat (U per L) TP (g_dL) ALB (g_dL) Creat Kinase (IU_L) ALT (IU_L) SDH (IU_L) 5'Nuc (IU_L) TBA (umol per g) Cholesterol (mg per dL) Triglyceride (mg per dL)
Day 5 0181 0 V 0.6 5.8 4.3 704 39 19 34.4 30.8 106 266
Day 5 0182 0 V 0.6 5.6 4.1 375 30 17.2 36.3 64.7 83 96
Day 5 0183 0 V 0.6 5.9 4.3 382 38 17.2 38.1 56.3 102 94
Day 5 0184 0 V 0.7 5.9 4.3 534 34 20.2 32 32.8 81 188
Day 5 0185 0 V 0.6 6.4 4.4 849 35 20.2 36.9 34.8 97 98
Day 5 0186 0 V 0.6 5.9 4.4 474 32 18.4 36.3 36.8 87 225
Day 5 0187 0 V 0.6 5.7 4.2 575 42 21.5 32.6 55.3 99 117
Day 5 0188 0 V 0.6 6.1 4.5 575 42 23.9 38.1 47.5 88 90
Day 5 0189 0 V 0.6 6 4.4 712 37 23.3 37.5 50.6 93 76
Day 5 0190 0 V 0.7 5.8 4.3 617 39 18.4 36.3 46.9 101 208
Day 5 0191 80 0.6 5.7 4.2 494 39 17.2 36.9 45.3 78 119
Day 5 0192 80 0.6 6.1 4.5 1093 41 21.5 43 38.1 85 205
Day 5 0193 80 0.6 6.1 4.5 817 40 15.3 44.2 19.5 101 208
Day 5 0194 80 0.6 5.8 4.2 460 36 11 38.7 50.6 76 140
Day 5 0195 80 0.7 5.8 4.2 727 40 18.4 40 17.8 79 162
Day 5 0196 80 0.7 5.6 4.2 619 44 20.8 34.4 21.5 82 164
Day 5 0197 80 0.6 5.9 4.3 618 36 19.6 36.3 45.1 79 160
Day 5 0198 80 0.6 5.9 4.3 357 42 19.6 34.4 42.5 85 126
Day 5 0199 80 0.7 5.9 4.4 558 43 22.7 40 41.6 88 186
Day 5 0200 80 0.6 6 4.4 279 39 15.3 35.7 50.9 84 139
Day 5 0201 160 0.6 5.6 4.2 398 42 22.1 32.6 50.9 75 195
Day 5 0202 160 0.7 6 4.4 515 39 19 36.9 27.9 81 154
Day 5 0203 160 0.6 5.6 4.2 946 40 19 37.5 42 65 124
Day 5 0204 160 0.6 6 4.4 920 44 25.1 41.2 37.6 76 168
Day 5 0205 160 0.6 5.5 4.1 361 49 14.7 32.6 42.2 75 86
Day 5 0206 160 0.6 6.1 4.4 644 44 22.1 40 38.5 82 174
Day 5 0207 160 0.6 5.8 4.3 648 38 18.4 38.7 27.5 80 144
Day 5 0208 160 0.6 6.1 4.5 358 42 17.2 39.3 34.7 91 183
Day 5 0209 160 0.6 5.4 4.1 469 45 19 30.8 47.8 71 161
Day 5 0210 160 0.6 5.9 4.3 492 46 21.5 40 34.3 81 172
Day 5 0211 315 0.6 5.8 4.3 617 40 19.6 36.9 51.9 68 169
Day 5 0212 315 0.6 5.7 4.2 627 38 21.5 30.8 44 71 204
Day 5 0213 315 0.6 5.9 4.4 360 43 15.9 33.8 17.1 78 226
Day 5 0214 315 0.6 5.7 4.4 360 46 20.2 29.5 29.2 69 231
Day 5 0215 315 0.6 5.8 4.4 394 41 14.7 31.4 50.8 63 216
Day 5 0216 315 0.6 5.8 4.3 1083 37 15.3 38.1 38.3 61 110
Day 5 0217 315 0.6 5.9 4.4 867 48 15.3 34.4 33 77 176
Day 5 0218 315 0.6 5.8 4.2 390 36 19 33.2 37.9 68 170
Day 5 0219 315 0.5 5.5 4.1 404 40 15.3 32.6 44.5 65 117
Day 5 0220 315 0.6 5.8 4.2 576 43 23.3 30.1 45.1 59 103
Day 5 0221 625 0.6 5.6 4.2 550 53 19.6 23.4 35.8 58 246
Day 5 0222 625 0.6 5.6 4.3 371 41 17.8 28.9 33 50 133
Day 5 0223 625 0.6 5.5 4.2 195 46 15.3 27.1 22.2 58 141
Day 5 0224 625 0.6 5.5 4.1 707 49 16.6 28.3 41.4 47 114
Day 5 0225 625 0.6 5.5 4.1 466 47 17.2 30.8 39.4 61 166
Day 5 0226 625 0.6 5.9 4.4 711 51 22.7 31.4 35 60 170
Day 5 0227 625 0.6 5.8 4.3 440 45 19.6 32 33.7 63 190
Day 5 0228 625 0.6 5.9 4.5 689 60 23.3 32.6 52.8 59 141
Day 5 0229 625 0.6 5.8 4.4 708 43 20.2 31.4 26 64 210
Day 5 0230 625 0.6 5.9 4.4 1110 50 19.6 39.3 22.9 75 275
Day 5 0231 1250 0.5 5.3 4 470 45 18.4 25.2 34.8 41 93
Day 5 0232 1250 0.5 5.3 4.1 805 53 22.7 28.3 28.4 37 63
Day 5 0233 1250 0.6 5.8 4.4 2176 66 22.1 36.3 44 229
Day 5 0234 1250 0.6 5.1 3.8 310 50 19 21.6 20.7 36 82
Day 5 0235 1250 0.5 5.4 4.1 508 49 22.1 28.3 23.1 44 54
Day 5 0236 1250 0.6 5.7 4.3 826 58 18.4 25.2 33 44 83
Day 5 0237 1250 0.6 5.7 4.3 666 40 18.4 26.5 18 44 180
Day 5 0238 1250 0.6 5.5 4.2 538 40 22.1 29.5 19.1 45 135
Day 5 0239 1250 0.7 5.9 4.5 834 57 37.4 32 27.7 47 150
Day 5 0240 1250 0.5 5.6 4.2 683 47 19 28.9 32.5 43 177
Day 19 0181 0 V 0.6 6.2 4.5 665 33 20.2 43.6 30.4 91 178
Day 19 0182 0 V 0.6 6.1 4.5 470 37 19 22.8 36.1 37* 103
Day 19 0183 0 V 0.6 6.3 4.6 497 33 23.3 43.6 36.1 87 127
Day 19 0184 0 V 0.6 6.1 4.4 550 29 22.7 36.3 24.4 82 107
Day 19 0185 0 V 0.7 6.1 4.4 384 27 31.3 33.8 23.3 87 126
Day 19 0186 0 V 0.6 6.4 4.7 299 27 26.4 38.1 30.2 86 182
Day 19 0187 0 V 0.6 6.3 4.5 719 31 15.3 40.6 40.3 90 107
Day 19 0188 0 V 0.7 6.4 4.7 333 29 26.4 36.9 30.6 102 108
Day 19 0189 0 V 0.7 6.5 4.7 497 30 28.8 37.5 31.9 94 101
Day 19 0190 0 V 0.7 6.2 4.5 495 32 24.5 41.2 28.7 94 131
Day 19 0191 80 0.7 6 4.4 344 35 25.8 39.3 24.2 75 177
Day 19 0192 80 0.7 6.4 4.7 684 32 30.7 40.6 33.7 82 147
Day 19 0193 80 0.6 6.4 4.7 194 38 20.2 43 28.6 87 207
Day 19 0194 80 0.6 6 4.3 737 40 25.1 35.7 24.9 68 153
Day 19 0195 80 0.6 6.1 4.5 336 35 19 35.7 15 73 168
Day 19 0196 80 0.6 5.9 4.3 687 33 20.2 35.7 21.8 66 205
Day 19 0197 80 0.6 6.1 4.4 428 32 19.6 36.9 38.2 70 174
Day 19 0198 80 0.6 6 4.4 524 36 17.8 40 37 71 166
Day 19 0199 80 0.6 5.9 4.3 340 35 22.7 38.1 34 69 124
Day 19 0200 80 0.6 6.1 4.4 162 33 14.7 32 21.6 63 175
Day 19 0201 160 0.9 5.9 4.4 331 34 22.7 33.8 40.3 53 263
Day 19 0202 160 0.6 6 4.4 360 36 20.2 25.2 37.9 45 200
Day 19 0203 160 0.6 6.3 4.6 417 37 18.4 28.3 56.2 46 127
Day 19 0204 160 0.6 5.8 4.2 981 37 15.9 27.1 56.9 46 163
Day 19 0205 160 0.5 6.1 4.4 205 41 16.6 26.5 87.2 51 190
Day 19 0206 160 0.7 6.4 4.7 588 33 26.4 32.6 26.7 58 273
Day 19 0207 160 0.6 6.6 4.9 931 43 27.6 39.3 25.5 68 399
Day 19 0208 160 0.7 6.6 4.8 1553 41 25.1 35.1 26.4 56 282
Day 19 0209 160 0.6 6.1 4.4 363 34 23.9 27.7 34.6 52 178
Day 19 0210 160 0.6 6.2 4.6 596 39 23.9 32 20.3 58 290
Day 19 0211 315 0.6 5.9 4.3 378 34 18.4 27.7 24.2 68 220
Day 19 0212 315 0.6 6 4.3 662 37 20.8 22.8 35.7 38 179
Day 19 0213 315 0.6 5.7 4.2 302 33 14.7 25.9 27.5 46 288
Day 19 0214 315 0.6 5.9 4.3 392 40 20.8 22.8 37.3 31 126
Day 19 0215 315 0.6 5.9 4.4 454 34 23.3 20.9 27.8 34 191
Day 19 0216 315 0.6 6 4.4 638 34 22.1 25.9 44.8 41 197
Day 19 0217 315 0.6 6.3 4.8 960 36 23.9 26.5 35.7 47 569
Day 19 0218 315 0.6 6 4.4 249 30 23.9 19.7 28.4 33 351
Day 19 0219 315 0.5 6.1 4.5 344 34 14.7 25.2 34.8 45 312
Day 19 0220 315 0.6 6.3 4.6 377 40 22.1 21.6 53.8 34 187
Day 19 0221 625 0.6 5.5 4.1 958 47 22.1 14.2 34.8 25 41
Day 19 0222 625 0.6 6 4.5 286 46 25.8 16.7 66.4 27 76
Day 19 0223 625 0.5 5.8 4.3 313 57 24.5 18.5 37.7 29 115
Day 19 0224 625 0.6 6.2 4.7 479 36 23.3 19.7 52 30 332
Day 19 0225 625 0.5 5.9 4.4 1027 50 19.6 20.3 45.6 25 87
Day 19 0226 625 0.6 6 4.5 1915 46 19.6 26.5 55.1 30 232
Day 19 0227 625 0.6 6.2 4.6 274 49 23.9 20.3 44.5 33 146
Day 19 0228 625 0.5 5.8 4.3 623 59 19.6 18.5 64.2 24 95
Day 19 0229 625 0.6 5.7 4.3 886 50 18.4 16.7 52.1 20 37
Day 19 0230 625 0.6 5.8 4.4 581 35 15.9 20.9 32.8 40 395
Day 19 0231 1250 0.6 6.1 4.5 688 51 19 17.9 64.4 29 46
Day 19 0232 1250 0.5 5.9 4.3 376 58 19 15.4 48.8 23 47
Day 19 0233 1250 0.5 5.9 4.3 1825 44 19 23.4 46.3 27 125
Day 19 0234 1250 0.5 5.9 4.3 507 50 19 16 58.3 26 123
Day 19 0235 1250 0.5 6 4.4 749 46 23.3 17.3 52.3 30 99
Day 19 0236 1250 0.6 6.2 4.7 835 37 16.6 19.7 37.2 33 99
Day 19 0237 1250 0.6 6.1 4.5 594 33 17.2 20.3 43 29 206
Day 19 0238 1250 0.6 6.1 4.6 2009 53 25.1 23.4 23.1 33 247
Day 19 0239 1250 0.6 6.1 4.5 441 47 23.3 18.5 39.9 26 51
Day 19 0240 1250 0.6 6.3 4.7 382 24 20.2 21.6 39 34 520
Week 13 0061 0 V 0.6 6.5 4.7 194 44 14.7 41.8 19.3 92 159
Week 13 0062 0 V 0.6 7 5 231 40 15.9 33.2 20.4 100 87
Week 13 0063 0 V 0.6 6.8 4.9 153 47 16.6 27.7 68.6 91 193
Week 13 0064 0 V 0.7 7 4.9 209 39 19.6 32 43.7 95 213
Week 13 0065 0 V 0.6 6.9 4.8 226 40 15.3 31.4 29.9 105 139
Week 13 0066 0 V 0.7 5.8 4.3 528 61 30 30.8 14.9 77 110
Week 13 0067 0 V 0.6 6.7 5 143 44 18.4 36.3 32 97 136
Week 13 0068 0 V 0.6 6.6 4.8 258 68 23.3 36.3 63.1 100 177
Week 13 0069 0 V 0.8 6.7 4.9 275 51 20.2 40 31.8 95 192
Week 13 0070 0 V 0.6 6.6 4.7 108 49 18.4 35.7 39.3 95 117
Week 13 0071 80 0.5 6.7 5 896 44 45.4 33.2 25 47 484
Week 13 0072 80 0.5 6.5 4.9 288 52 17.8 19.1 34.3 38 239
Week 13 0073 80 0.6 6.5 5.2 198 46 76.7 26.5 51.3 54 854
Week 13 0074 80 0.6 6.5 4.9 221 52 23.3 22.8 37.5 42 422
Week 13 0075 80 0.6 6.6 5.1 230 48 17.2 29.5 35.9 50 641
Week 13 0076 80 0.5 5.5 3.9 178 35 19.6 22.8 25.1 40 256
Week 13 0077 80 0.6 6.7 4.9 180 39 22.1 29.5 23.5 41 257
Week 13 0078 80 0.6 6.5 4.7 181 45 22.7 29.5 35 41 237
Week 13 0079 80 0.6 6.6 4.9 158 45 22.1 25.9 24.2 45 272
Week 13 0080 80 0.6 7.1 5.2 195 46 20.8 27.7 23.5 39 314
Week 13 0081 160 0.5 6.4 4.8 559 46 18.4 24.6 10.5 20 75
Week 13 0082 160 0.4 6.3 4.8 327 48 15.9 22.2 26.5 18 127
Week 13 0083 160 0.6 6.4 4.9 282 47 23.3 22.2 12.9 23 85
Week 13 0084 160 0.6 6.9 5.1 164 48 22.7 24.6 35 30 260
Week 13 0085 160 0.5 6.6 5 213 51 23.9 22.2 22.1 21 61
Week 13 0086 160 0.5 6.9 5.2 207 38 13.5 24 31.1 34 532
Week 13 0087 160 0.5 6.6 5 160 41 19.6 24 25 30 264
Week 13 0088 160 0.6 6.3 4.8 417 48 22.7 24 18.1 26 151
Week 13 0089 160 0.5 6.8 5.3 155 40 17.8 19.1 33.1 26 240
Week 13 0090 160 0.5 6.7 5.1 278 47 31.3 19.1 21.8 18 128
Week 13 0091 315 0.5 6.2 4.8 348 54 20.2 16 17.7 13 121
Week 13 0092 315 0.5 6.1 4.7 277 55 23.9 19.1 16.7 16 91
Week 13 0093 315 0.5 6.1 4.8 248 50 19.6 20.3 12.1 23 206
Week 13 0094 315 0.4 6.1 4.8 456 46 19.6 20.9 26.4 21 206
Week 13 0095 315 0.5 6.2 4.6 295 39 20.8 19.1 22.1 17 130
Week 13 0096 315 0.5 6.4 4.8 134 43 16.6 17.9 30.1 28 311
Week 13 0097 315 0.5 6.8 5.2 1221 45 22.1 27.1 28.5 35 510
Week 13 0098 315 0.5 6.7 5.1 387 41 20.2 17.9 30.6 26 217
Week 13 0099 315 0.5 6.6 4.9 265 52 19.6 18.5 36.3 24 185
Week 13 0100 315 0.5 6.7 5 216 58 25.1 18.5 35.5 23 181
Week 13 0101 625 0.5 6.5 5 275 56 43.5 19.7 52.7 34 579
Week 13 0102 625 0.5 5.7 4.5 343 48 20.8 16.7 22.3 12 171
Week 13 0103 625 0.4 5.4 4.3 134 37 11.7 16 14.2 14 173
Week 13 0104 625 0.4 6 4.7 257 51 19 17.3 30.8 19 226
Week 13 0105 625 0.4 6.2 4.8 199 44 19 26.5 16 211
Week 13 0106 625 0.5 6.3 4.9 100 41 14.1 18.5 21.8 20 238
Week 13 0107 625 0.5 6.4 4.9 647 50 19 22.2 26.2 19 178
Week 13 0108 625 0.5 6.6 5 256 48 19.6 19.7 21.8 14 128
Week 13 0109 625 0.5 6.1 4.7 304 56 18.4 17.9 22.5 16 149
Week 13 0110 625 0.4 6 4.6 233 52 17.8 21.6 45.1 21 317
Week 13 0111 1250 0.5 6 4.6 190 41 15.9 19.1 37.8 26 242
Week 13 0112 1250 0.4 6 4.5 324 45 19.6 19.7 19.7 20 178
Week 13 0113 1250 0.5 6.2 4.7 293 38 25.1 17.9 27.1 20 284
Week 13 0114 1250 0.5 5.5 4.1 463 57 27.6 19.7 15.2 17 138
Week 13 0115 1250 0.4 6.4 4.9 265 47 23.3 20.3 41.2 26 385
Week 13 0116 1250 0.5 6.3 4.6 230 51 31.9 19.1 19.3 21 212
Week 13 0117 1250 0.5 6.3 4.8 207 48 58.3 17.9 43.5 23 331
Week 13 0118 1250 0.4 6.4 4.8 114 41 15.3 19.7 29.9 27 369
Week 13 0119 1250 0.4 6.2 4.5 100 40 12.9 16 35.2 21 270
Abbreviations:
NA: Not Available, V: Vehicle Control, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, 5'Nuc: 5 Prime Nucleotidase, TBA: Bile Acids Per G Tissue, Triglyceride: Triglycerides