If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Clinical Chemistry Individual Animal

Study Information:

Chemical Name: Oxymetholone
CASRN: ="434-07-1"
Study Number: C88032B
Study Length (Year Completed): 13 Weeks (N/A)
Exposure Route: GAV
TDMS Number: 8803203.ss
Sex: Male
Strain and Species: Fischer 344 Rats

Clinical Chemistry Individual Animal Data
Measurement Time Animal Number Dose Group (mg/kg) Control Code Creat (U per L) TP (g_dL) ALB (g_dL) Creat Kinase (IU_L) ALT (IU_L) SDH (IU_L) 5'Nuc (IU_L) TBA (umol per g) Cholesterol (mg per dL) Triglyceride (mg per dL)
Day 5 0121 0 V 0.6 6.1 4.3 632 37 18.4 33.2 49.5 86 189
Day 5 0122 0 V 0.6 6 4.3 1078 47 18.4 36.9 73.2 95 135
Day 5 0123 0 V 0.6 6 4.3 805 34 17.2 34.4 19.1 83 133
Day 5 0124 0 V 0.6 6.3 4.4 576 35 22.1 31.4 35.1 78 151
Day 5 0125 0 V 0.6 5.8 4.1 678 47 20.8 30.1 74.6 89 126
Day 5 0126 0 V 0.7 6.1 4.4 763 46 23.3 33.2 75.8 83 122
Day 5 0127 0 V 0.6 6.4 4.5 389 36 23.9 27.7 20.2 70 233
Day 5 0128 0 V 0.6 6.1 4.3 775 34 18.4 32.6 29.3 82 196
Day 5 0129 0 V 0.7 6.4 4.6 790 34 21.5 32.6 23.8 78 206
Day 5 0130 0 V 0.6 6.4 4.5 905 42 22.7 32.6 66.7 76 96
Day 5 0131 80 0.6 5.6 4 690 41 21.5 25.9 45 61 98
Day 5 0132 80 0.6 6 4.3 1045 52 15.9 32.6 46.7 70 189
Day 5 0133 80 0.6 6.1 4.4 606 37 22.7 27.7 33.4 67 192
Day 5 0134 80 0.6 6.4 4.5 426 43 24.5 30.1 32.7 64 152
Day 5 0135 80 0.6 6.3 4.5 628 37 25.8 32.6 45.4 65 204
Day 5 0136 80 0.6 6.2 4.4 1140 47 25.1 38.1 28.4 58 186
Day 5 0137 80 0.6 6 4.2 562 37 23.3 27.1 24 51 130
Day 5 0138 80 0.6 6.4 4.6 1496 49 22.7 36.3 21.8 67 217
Day 5 0139 80 0.6 6.5 4.6 423 40 23.9 28.3 15.4 51 308
Day 5 0140 80 0.7 6.2 4.4 865 36 19 30.1 28.8 59 150
Day 5 0141 160 0.6 6.3 4.6 1002 42 24.5 25.2 44.7 36 417
Day 5 0142 160 0.6 6.3 4.6 629 38 19.6 27.7 14.8 51 305
Day 5 0143 160 0.6 6.1 4.4 550 48 19.6 30.1 23.6 65 263
Day 5 0144 160 0.5 5.9 4.2 352 42 19.6 27.7 46.7 61 149
Day 5 0145 160 0.6 6.1 4.5 810 39 15.3 28.9 21.1 48 311
Day 5 0146 160 0.6 6.3 4.6 800 49 21.5 27.1 19.1 39 468
Day 5 0147 160 0.6 6.1 4.4 961 54 25.8 29.5 60.6 58 162
Day 5 0148 160 0.6 6.2 4.5 1043 59 26.4 36.9 69.9 66 177
Day 5 0149 160 0.6 5.8 4.3 763 42 17.8 28.3 46.5 54 235
Day 5 0150 160 0.6 6.1 4.3 267 37 20.8 25.9 38.6 61 160
Day 5 0151 315 0.6 5.7 4.2 828 37 17.2 21.6 17.7 27 301
Day 5 0152 315 0.5 5.7 4.2 703 56 16.6 21.6 61.2 30 265
Day 5 0153 315 0.6 6 4.5 592 42 20.2 22.2 49.7 36 273
Day 5 0154 315 0.6 5.9 4.2 1244 54 16.6 28.9 54.6 40 207
Day 5 0155 315 0.6 5.8 4.3 520 38 17.2 22.8 54.4 37 378
Day 5 0156 315 0.6 6 4.3 680 45 19.6 23.4 66.7 32 177
Day 5 0157 315 0.6 6 4.3 622 42 22.1 25.2 42.4 37 419
Day 5 0158 315 0.6 5.8 4.2 713 46 20.2 27.7 57.1 49 190
Day 5 0159 315 0.6 5.6 4.1 568 54 20.8 25.2 57.4 51 240
Day 5 0160 315 0.6 5.8 4.2 790 36 17.8 23.4 36.3 34 365
Day 5 0161 625 0.7 5.4 4 608 43 25.8 22.8 11.1 35 209
Day 5 0162 625 0.6 5.9 4.2 610 53 31.3 22.8 58.1 34 170
Day 5 0163 625 0.6 5.9 4.3 1468 48 18.4 24.6 36.8 31 202
Day 5 0164 625 0.6 5.6 4.1 1955 61 19 28.9 31.3 38 101
Day 5 0165 625 0.5 5.6 4 782 52 17.2 20.3 63 33 91
Day 5 0166 625 0.6 6 4.4 2013 69 21.5 31.4 64.2 43 199
Day 5 0167 625 0.6 5.8 4.3 362 28 14.7 17.9 28.3 18 340
Day 5 0168 625 0.5 5.6 4.1 620 54 19.6 17.9 38.3 22 75
Day 5 0169 625 0.5 6.1 4.5 407 39 22.1 20.9 34.5 47 508
Day 5 0170 625 0.6 5.6 4.1 2220 68 19 35.7 40 26 231
Day 5 0171 1250 0.5 5.7 4 544 49 20.2 17.3 31.3 19 79
Day 5 0172 1250 0.5 5.2 3.7 1074 52 17.8 18.5 23.8 18 143
Day 5 0173 1250 0.6 5.6 4.1 1037 53 18.5 24.6 16.3 45 399
Day 5 0174 1250 0.5 5.8 4.3 989 83 31.9 22.2 56 22 67
Day 5 0175 1250 0.6 5.9 4.3 400 46 29.4 18.5 29.5 33 288
Day 5 0176 1250 0.6 5.6 4.1 736 42 27 22.2 32.7 41 282
Day 5 0177 1250 0.6 5.7 4.2 853 54 18.4 23.4 33.4 33 190
Day 5 0178 1250 0.6 5.9 4.1 1163 47 15.9 19.1 50.4 33 208
Day 5 0179 1250 0.6 5.8 4.1 839 42 22.7 17.9 45.4 25 306
Day 5 0180 1250 0.5 5.6 4 402 36 19.6 20.9 21.8 39 311
Day 19 0121 0 V 0.6 6.5 4.5 234 37 20.2 28.3 47.8 70 230
Day 19 0122 0 V 0.6 6.3 4.4 498 38 20.2 32 42.6 76 198
Day 19 0123 0 V 0.6 6.3 4.5 208 35 18.4 29.5 19.8 71 244
Day 19 0124 0 V 0.7 6.4 4.6 450 39 22.1 28.3 32 72 311
Day 19 0125 0 V 0.6 6.4 4.6 1056 38 20.2 35.1 37.2 74 164
Day 19 0126 0 V 0.6 6.4 4.5 819 34 18.4 28.9 36.1 81 220
Day 19 0127 0 V 0.6 6.8 4.7 383 48 22.7 30.1 21.6 71 295
Day 19 0128 0 V 0.6 6.3 4.5 481 36 16.6 28.9 21.8 70 276
Day 19 0129 0 V 0.7 7 4.9 2328* 52 32.5 39.3 22.7 74 294
Day 19 0130 0 V 0.6 6.6 4.6 585 37 19.6 28.9 62.4 66 184
Day 19 0131 80 0.6 6 4.3 472 34 18.4 24 45.8 47 157
Day 19 0132 80 0.6 6.2 4.5 325 37 21.5 27.7 21.8 51 340
Day 19 0133 80 0.6 6 4.3 290 36 15.3 27.1 18.2 49 255
Day 19 0134 80 0.6 6.4 4.6 504 36 18.4 27.1 40.8 50 336
Day 19 0135 80 0.6 6.2 4.4 289 30 17.8 24.6 44.4 47 251
Day 19 0136 80 0.6 6.1 4.3 263 40 17.2 24.6 36 44 116
Day 19 0137 80 0.6 6.5 4.5 370 33 17.2 30.8 63.5 46 186
Day 19 0138 80 0.7 6 4.4 518 35 21.5 28.3 27 52 351
Day 19 0139 80 0.6 6.3 4.6 409 38 20.8 27.1 19.5 47 506
Day 19 0140 80 0.6 6.4 4.6 402 39 20.8 25.9 43.6 45 229
Day 19 0141 160 0.6 6.5 4.8 309 37 19.6 22.8 63.7 35 371
Day 19 0142 160 0.6 6.5 4.8 340 33 19 24.6 35.6 39 468
Day 19 0143 160 0.6 6 4.3 291 36 14.1 25.2 57.1 41 353
Day 19 0144 160 0.5 6.3 4.6 364 35 16.6 25.9 43.8 42 310
Day 19 0145 160 0.6 6.4 4.7 434 40 19.6 25.2 39 36 291
Day 19 0146 160 0.5 6.4 4.7 635 38 16.6 25.9 42.6 41 528
Day 19 0147 160 0.5 6.1 4.4 772 45 18.4 25.2 43.6 35 91
Day 19 0148 160 0.6 5.9 4.3 287 38 15.9 26.5 37.2 42 280
Day 19 0149 160 0.6 5.7 4.3 543 47 20.8 22.2 22.7 35 258
Day 19 0150 160 0.6 6.3 4.5 453 38 15.3 25.9 48.3 37 303
Day 19 0151 315 0.6 6.5 4.9 185 34 9.8 17.9 46.1 30 574
Day 19 0152 315 0.5 6.1 4.6 383 42 12.3 20.9 59.6 32 359
Day 19 0153 315 0.6 6.5 4.9 658 34 19 23.4 55.1 28 406
Day 19 0154 315 0.5 6.3 4.6 415 39 16.6 20.9 71.9 30 357
Day 19 0155 315 0.6 6.3 4.6 1145 41 15.3 24.6 46.1 26 383
Day 19 0156 315 0.5 6.3 4.6 295 46 17.8 17.9 56.3 16 179
Day 19 0157 315 0.6 6.1 4.6 395 37 17.2 20.3 55.8 31 555
Day 19 0158 315 0.6 6.2 4.5 416 47 19.6 19.1 45.4 29 202
Day 19 0159 315 0.6 5.8 4.4 396 38 12.9 22.8 37.2 32 377
Day 19 0160 315 0.5 6.3 4.5 410 40 17.2 18.5 49.7 31 298
Day 19 0161 625 0.6 6.1 4.5 331 33 19 16.7 34.7 22 215
Day 19 0162 625 0.5 6.6 4.8 573 30 11.7 19.1 34 28 377
Day 19 0163 625 0.5 6.5 4.8 405 54 23.9 16.7 32.9 21 91
Day 19 0164 625 0.5 5.9 4.3 898 45 17.2 18.5 44.7 24 168
Day 19 0165 625 0.5 6.6 4.9 1243 53 22.7 22.8 53.3 26 180
Day 19 0166 625 0.5 6.4 4.6 341 59 15.9 19.1 52.2 37 253
Day 19 0167 625 0.5 6.9 5 265 38 14.7 17.9 44.7 27 322
Day 19 0168 625 0.6 6.3 4.5 531 49 20.2 17.9 60.3 35 324
Day 19 0169 625 0.6 6.7 4.9 390 35 15.9 19.7 50.8 36 584
Day 19 0170 625 0.6 6.7 5.1 636 53 24.5 23.4 52.2 40 465
Day 19 0171 1250 0.6 6.6 4.9 230 29 11.7 15.4 34.9 20 309
Day 19 0172 1250 0.6 6.3 4.7 335 30 19 16.7 30.9 27 335
Day 19 0173 1250 0.5 6.1 4.6 508 39 15.3 19.7 29.5 36 387
Day 19 0174 1250 0.5 6 4.4 381 56 12.3 16.7 53.7 21 164
Day 19 0175 1250 0.5 6.7 4.9 378 39 17.2 17.3 43.1 25 330
Day 19 0176 1250 0.5 6 4.5 437 48 16.6 15.4 36.7 21 177
Day 19 0177 1250 0.5 6 4.5 626 30 19 19.7 33.8 31 286
Day 19 0178 1250 0.6 6.6 5 1733 50 20.2 26.5 33.8 29 257
Day 19 0179 1250 0.6 6.5 4.8 1011 58 17.8 19.1 49 16 294
Day 19 0180 1250 0.5 6.2 4.7 296 40 12.9 16.7 39.7 27 408
Week 13 0001 0 V 0.7 6.7 4.6 168 48 17.2 38.7 11.7 77 168
Week 13 0002 0 V 0.7 6.7 4.7 217 58 21.5 35.1 23.9 80 230
Week 13 0003 0 V 0.7 6.8 4.8 186 49 19.6 34.4 5.4 73 250
Week 13 0004 0 V 0.7 6.9 4.8 367 56 24.5 39.3 16.3 87 363
Week 13 0005 0 V 0.7 7 4.8 400 53 21.5 42.4 22.1 85 278
Week 13 0006 0 V 0.7 7.4 5.3 188 58 23.9 30.1 28.8 103 481
Week 13 0007 0 V 0.7 7.3 4.9 127 61 17.2 37.5 20.8 91 208
Week 13 0008 0 V 0.7 7.2 5.1 392 46 20.2 36.9 17.8 80 292
Week 13 0009 0 V 0.7 6.9 4.9 194 52 20.2 36.3 16.9 86 410
Week 13 0010 0 V 0.7 7 4.9 189 48 15.3 28.9 30.2 85 302
Week 13 0011 80 0.6 7 5.2 367 45 19.6 22.2 20 33 278
Week 13 0012 80 0.7 6.9 5 709 56 19.6 31.4 29.7 30 275
Week 13 0013 80 0.6 6.6 4.9 172 44 20.2 27.1 35.1 32 286
Week 13 0014 80 0.5 7.1 5.2 239 55 19.6 27.7 54.5 33 307
Week 13 0015 80 0.6 6.9 4.9 160 60 21.5 30.1 19.5 32 331
Week 13 0016 80 0.6 7.1 5.1 167 50 15.3 30.8 19.5 34 301
Week 13 0017 80 0.7 6.7 4.8 222 44 15.9 33.8 11.3 32 252
Week 13 0018 80 0.7 6.6 4.8 217 50 17.8 29.5 25.6 36 363
Week 13 0019 80 0.7 6.6 4.7 161 44 17.8 30.8 14.1 29 206
Week 13 0020 80 0.9 7.2 5.2 191 43 14.7 28.3 28.6 28 234
Week 13 0021 160 0.6 7.2 5.3 454 43 16.6 19.1 44.3 26 246
Week 13 0022 160 0.6 7.2 5.3 320 41 17.2 24 15.9 27 286
Week 13 0023 160 0.6 7 5.1 138 39 16.6 25.9 17.1 24 169
Week 13 0024 160 0.5 7.1 5.2 191 43 14.7 23.4 30 26 180
Week 13 0025 160 0.6 7.7 5.5 563 50 14.7 25.2 33.8 28 204
Week 13 0026 160 0.6 7 5.1 291 43 19 28.9 19.7 24 246
Week 13 0027 160 0.6 6.9 5.1 256 41 19 26.5 14.8 28 139
Week 13 0028 160 0.6 7.1 5.2 238 60 23.3 28.9 38.6 29 172
Week 13 0029 160 0.6 7 5.2 206 37 16.6 25.9 15.4 28 329
Week 13 0030 160 0.6 7 5.1 189 45 15.3 25.2 38.4 24 177
Week 13 0031 315 0.6 7.1 5.1 317 52 20.2 22.8 32.6 29 384
Week 13 0032 315 0.6 6.9 5.2 231 40 20.8 20.3 22.6 24 363
Week 13 0033 315 0.7 7 5.1 296 42 20.2 16.7 50.1 21 220
Week 13 0034 315 0.6 7 5.2 305 37 14.1 19.7 32.1 29 490
Week 13 0035 315 0.5 7 5 215 36 16.6 17.9 30.6 25 296
Week 13 0036 315 0.6 6.7 5 218 46 18.4 17.9 45.6 10 87
Week 13 0037 315 0.6 6.8 5 281 43 12.9 21.6 19.8 19 318
Week 13 0038 315 0.6 6.8 5.1 232 42 13.5 22.8 37.7 19 208
Week 13 0039 315 0.6 6.9 5.1 140 46 14.7 20.3 47.3 19 412
Week 13 0040 315 0.6 7 5 362 43 15.9 21.6 19.5 15 148
Week 13 0042 625 0.5 6.4 5 217 22 10.4 17.3 29.1 13 357
Week 13 0043 625 0.5 6.6 5.1 178 45 8.6 16.7 39.9 18 324
Week 13 0044 625 0.5 6.4 4.9 301 41 14.7 17.3 28.4 17 350
Week 13 0045 625 0.5 6.5 5.1 264 39 42.3 14.8 31.9 21 593
Week 13 0046 625 0.5 6.4 4.8 221 45 12.3 19.1 38.6 18 340
Week 13 0047 625 0.5 6.5 4.8 299 35 10.4 19.7 32.3 22 454
Week 13 0048 625 0.5 5.9 4.5 168 36 15.9 20.9 24.7 32 694
Week 13 0049 625 0.5 6.4 5.1 322 19 55.2 20.3 17.1 17 555
Week 13 0050 625 0.5 6.4 4.9 409 40 15.3 17.3 34.1 17 348
Week 13 0051 1250 0.5 6.2 4.6 398 39 11 16.7 28.9 19 404
Week 13 0052 1250 0.5 6.1 4.6 163 46 64.4 17.9 43.8 16 336
Week 13 0053 1250 0.5 6.2 4.5 352 35 27.6 20.9 36.9 40 677
Week 13 0054 1250 0.5 6 4.5 364 36 14.1 16 26.3 14 266
Week 13 0055 1250 0.6 6.6 4.9 515 49 21.5 20.9 26.3 18 315
Week 13 0057 1250 0.5 6.5 4.9 183 35 11 17.9 26.3 16 365
Week 13 0058 1250 0.5 6.6 5 446 26 17.8 20.9 27.1 29 507
Week 13 0059 1250 0.5 6.4 4.9 376 35 12.3 16.7 25.8 19 479
Week 13 0060 1250 0.5 6.3 4.7 213 46 15.9 18.5 45.6 17 297
Abbreviations:
NA: Not Available, V: Vehicle Control, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, 5'Nuc: 5 Prime Nucleotidase, TBA: Bile Acids Per G Tissue, Triglyceride: Triglycerides