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Clinical Chemistry Individual Animal

Study Information:

Chemical Name: alpha/beta Thujone Mixture
CASRN: ="76231-76-0"
Study Number: C99037B
Study Length (Year Completed): 13 Weeks (N/A)
Exposure Route: GAV
TDMS Number: 9903798.ss
Sex: Male
Strain and Species: Fischer 344 Rats

Clinical Chemistry Individual Animal Data
Measurement Time Animal Number Dose Group (mg/kg) Control Code BUN (mg_dL) Creat (U per L) TP (g_dL) ALB (g_dL) Creat Kinase (IU_L) ALT (IU_L) SDH (IU_L) ALP (IU_L) TBA (umol per g)
Day 4 0121 0 18.0 0.5 5.4 4.1 657 47 4.0 595 24.6
Day 4 0122 0 17.4 0.5 5.6 4.0 629 50 10.0 694 30.0
Day 4 0123 0 16.5 0.5 5.9 4.2 535 52 11.4 660 20.0
Day 4 0124 0 16.1 0.5 5.8 4.1 603 54 4.6 657 19.1
Day 4 0125 0 14.4 0.5 5.6 4.0 426 48 8.0 602 26.6
Day 4 0126 0 17.0 0.5 5.8 4.2 413 50 7.3 593 29.1
Day 4 0127 0 15.7 0.5 5.8 4.2 702 62 2.0 722 26.5
Day 4 0128 0 14.5 0.5 5.8 4.3 628 54 1.5 611 17.9
Day 4 0129 0 15.7 0.5 5.6 4.1 694 52 3.7 611 34.1
Day 4 0130 0 14.0 0.5 5.6 4.0 598 61 1.7 655 29.4
Day 4 0131 12.5 16.1 0.5 5.4 4.0 628 48 4.0 620 24.3
Day 4 0132 12.5 19.4 0.5 5.8 4.2 527 58 6.3 608 21.8
Day 4 0133 12.5 16.7 0.5 5.6 4.0 652 54 5.3 620 17.6
Day 4 0134 12.5 15.6 0.5 5.8 4.1 366 52 10.5 579 20.2
Day 4 0135 12.5 15.5 0.5 5.5 4.0 435 60 8.5 633 25.2
Day 4 0136 12.5 14.7 0.5 5.7 4.1 579 52 3.5 617 27.9
Day 4 0137 12.5 14.1 0.5 5.7 4.2 574 63 4.2 629 19.1
Day 4 0138 12.5 14.9 0.5 5.8 4.3 483 61 5.9 639 27.3
Day 4 0139 12.5 14.5 0.5 5.7 4.2 471 53 7.0 641 24.8
Day 4 0140 12.5 12.8 0.4 5.7 4.0 696 58 0.5 637 28.8
Day 4 0141 25 17.1 0.5 5.4 4.0 616 46 6.3 656 19.1
Day 4 0142 25 15.4 0.5 5.6 4.1 468 55 12.2 668 20.6
Day 4 0143 25 16.0 0.5 5.8 4.1 472 59 9.6 659 20.1
Day 4 0144 25 17.3 0.5 5.8 4.1 430 57 8.7 583 19.5
Day 4 0145 25 14.3 0.5 5.8 4.2 530 61 5.4 623 20.1
Day 4 0146 25 15.3 0.5 5.7 4.1 808 53 0.0 608 23.8
Day 4 0147 25 15.1 0.5 5.7 4.2 601 54 4.7 581 19.9
Day 4 0148 25 16.1 0.5 5.8 4.2 398 54 11.5 630 19.2
Day 4 0149 25 16.0 0.6 6.1 4.4 452 68 10.4 607 25.1
Day 4 0150 25 15.2 0.5 6.0 4.2 470 58 4.9 605 22.0
Day 4 0151 50 17.0 0.5 5.5 4.0 614 49 9.3 591 20.9
Day 4 0152 50 17.0 0.5 6.1 4.3 496 57 16.8 626 30.5
Day 4 0153 50 17.6 0.5 5.9 4.3 420 54 8.0 611 30.7
Day 4 0154 50 16.6 0.5 6.2 4.2 583 60 4.9 618 21.5
Day 4 0155 50 16.4 0.5 5.5 4.1 464 53 9.2 631 26.5
Day 4 0156 50 13.4 0.4 5.4 4.0 477 54 3.3 603 34.3
Day 4 0157 50 14.6 0.5 5.9 4.3 658 53 0.4 662 27.2
Day 4 0158 50 16.3 0.5 5.7 4.2 498 56 6.9 611 20.5
Day 4 0159 50 17.4 0.5 6.3 4.3 473 52 9.3 626 26.4
Day 4 0160 50 15.0 0.5 5.8 4.1 720 53 2.8 584 20.3
Day 4 0161 75 16.1 0.4 5.4 3.9 724 54 5.7 599 22.4
Day 4 0162 75 17.8 0.5 5.5 3.9 738 49 6.3 554 22.6
Day 4 0163 75 16.4 0.5 5.9 4.1 591 63 4.2 579 18.6
Day 4 0164 75 18.1 0.5 6.3 4.6 301 61 11.2 673 25.1
Day 4 0165 75 15.4 0.5 5.6 4.1 518 59 3.0 595 21.6
Day 4 0166 75 15.2 0.5 5.5 4.0 609 50 0.3 606 27.1
Day 4 0167 75 15.9 0.5 6.0 4.4 517 56 7.9 593 21.0
Day 4 0168 75 14.8 0.5 5.7 4.1 714 49 0.8 639 25.0
Day 4 0169 75 16.4 0.5 5.8 4.2 630 61 4.8 610 21.2
Day 4 0170 75 13.1 0.4 5.7 4.2 629 66 0.5 621 21.2
Day 4 0171 100 16.1 0.5 5.4 4.0 537 53 6.6 589 20.6
Day 4 0172 100 17.9 0.5 5.7 4.2 557 56 8.6 638 17.7
Day 4 0173 100 18.3 0.5 6.3 4.4 596 49 8.1 603 23.7
Day 4 0174 100 20.0 0.5 6.1 4.2 518 52 3.8 552 24.1
Day 4 0175 100 14.5 0.5 6.0 4.2 437 61 9.5 613 30.8
Day 4 0176 100 16.3 0.5 5.8 3.9 375 79 16.2 477 24.7
Day 4 0177 100 16.6 0.5 6.0 4.3 493 53 5.1 582 19.8
Day 4 0178 100 13.5 0.5 5.6 4.1 525 56 3.5 577 20.0
Day 4 0179 100 14.4 0.5 5.6 4.1 592 62 2.2 640 19.0
Day 4 0180 100 12.9 0.5 6.1 4.3 403 63 7.2 603 23.1
Day 25 0121 0 21.5 0.6 5.9 4.1 208 55 12.4 375 26.3
Day 25 0122 0 22.4 0.6 6.2 4.3 216 61 12.7 392 17.8
Day 25 0123 0 20.5 0.5 6.2 4.3 266 67 6.8 417 15.9
Day 25 0124 0 21.6 0.6 6.5 4.4 157 61 12.7 412 19.3
Day 25 0125 0 23.7 0.6 6.4 4.3 337 63 12.5 409 23.6
Day 25 0126 0 19.6 0.6 6.1 4.2 162 59 14.2 377 25.2
Day 25 0127 0 22.0 0.6 6.4 4.3 363 61 11 378 35.1
Day 25 0128 0 21.3 0.6 6.8 4.5 166 67 14.7 399 21.8
Day 25 0129 0 22.6 0.6 6.1 4.3 334 69 9.7 419 28.8
Day 25 0130 0 19.5 0.7 6.5 4.3 222 58 15.3 422 38.9
Day 25 0131 12.5 18.4 0.6 6.2 4.3 211 49 13.4 388 30.8
Day 25 0132 12.5 14.9 0.6 6.0 4.2 295 53 11.3 378 29.2
Day 25 0133 12.5 18.7 0.6 6.4 4.3 231 61 9.0 421 18.8
Day 25 0134 12.5 15.9 0.7 6.3 4.1 310 54 10.1 367 19.0
Day 25 0135 12.5 17.7 0.6 6.1 4.3 181 56 14.2 384 19.4
Day 25 0136 12.5 18.0 0.6 6.0 4.2 196 53 15.6 381 28.3
Day 25 0137 12.5 16.6 0.6 5.9 4.1 334 60 7.9 377 16.6
Day 25 0138 12.5 18.8 0.6 6.6 4.3 382 53 12.9 388 25.8
Day 25 0139 12.5 18.3 0.6 6.4 4.2 270 57 14.4 409 24.3
Day 25 0140 12.5 19.3 0.6 6.3 4.2 346 56 8.8 404 21.0
Day 25 0141 25 21.8 0.6 6.4 4.3 161 56 13.8 389 30.7
Day 25 0142 25 20.7 0.6 6.6 4.3 199 59 17.1 388 19.5
Day 25 0143 25 20.6 0.6 6.4 4.4 232 61 12.1 411 18.7
Day 25 0144 25 22.0 0.6 6.6 4.4 281 69 10.6 390 27.0
Day 25 0145 25 22.3 0.6 6.6 4.4 297 70 14.6 418 21.8
Day 25 0146 25 19.0 0.6 6.2 4.2 166 55 13.1 384 31.9
Day 25 0147 25 17.3 0.6 6.3 4.3 209 52 16.1 372 20.9
Day 25 0148 25 17.6 0.6 6.3 4.2 304 58 17.8 405 24.3
Day 25 0149 25 17.8 0.6 6.4 4.3 361 57 7.6 406 25.3
Day 25 0150 25 17.8 0.6 6.4 4.2 277 59 14.6 430 31.5
Day 25 0151 50 18.9 0.6 6.2 4.3 176 59 15.9 415 16.6
Day 25 0152 50 19.7 0.6 6.5 4.4 167 65 14.0 377 30.1
Day 25 0153 50 20.3 0.6 6.4 4.3 208 57 13.8 411 26.3
Day 25 0154 50 21.4 0.6 6.5 4.3 312 56 8.3 386 24.1
Day 25 0155 50 20.5 0.6 6.2 4.3 212 54 11.5 398 29.5
Day 25 0156 50 17.2 0.5 5.9 4.2 171 52 11.1 352 19.7
Day 25 0157 50 17.6 0.6 6.3 4.2 298 56 18.3 379 25.5
Day 25 0158 50 16.8 0.6 6.4 4.2 421 55 13.1 380 19.5
Day 25 0159 50 17.3 0.6 6.3 4.3 206 54 15.4 401 23.5
Day 25 0160 50 15.8 0.6 6.3 4.3 350 51 6.9 385 22.0
Day 25 0161 75 21.2 0.6 6.0 4.1 266 67 15.9 368 26.9
Day 25 0162 75 21.0 0.7 6.5 4.4 324 67 8.3 378 30.8
Day 25 0163 75 21.3 0.6 6.1 4.3 250 62 11.1 384 30.9
Day 25 0164 75 22.0 0.6 6.3 4.4 200 64 9.4 383 27.3
Day 25 0165 75 23.3 0.6 6.1 4.2 299 65 7.6 398 20.0
Day 25 0166 75 17.2 0.6 6.1 4.2 274 56 7.5 367 24.7
Day 25 0167 75 17.3 0.6 6.3 4.2 259 59 16.3 356 23.4
Day 25 0168 75 16.6 0.6 6.5 4.5 177 57 15.7 391 17.5
Day 25 0169 75 17.8 0.6 6.0 4.2 400 52 8.5 353 33.2
Day 25 0170 75 18.1 0.6 6.3 4.3 403 56 6.2 390 23.7
Day 25 0171 100 16.8 0.6 6.0 4.2 210 54 12.8 411 30.6
Day 25 0172 100 17.7 0.6 6.3 4.3 193 58 11.4 407 19.0
Day 25 0173 100 17.9 0.7 6.7 4.4 250 55 8.1 347 18.4
Day 25 0174 100 19.6 0.6 6.3 4.3 263 58 5.6 373 22.7
Day 25 0175 100 18.5 0.6 6.0 4.3 246 57 8.8 375 29.5
Day 25 0176 100 21.5 0.6 6.3 4.2 266 64 11.1 378 25.3
Day 25 0177 100 19.8 0.6 6.6 4.4 215 61 16.2 388 19.4
Day 25 0178 100 20.0 0.6 6.1 4.2 230 67 15.8 369 30.0
Day 25 0179 100 21.1 0.7 6.3 4.2 272 59 11.6 382 20.1
Day 25 0180 100 18.3 0.6 6.4 4.2 256 63 12.5 402 24.3
Abbreviations:
NA: Not Available, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, ALP: Alkaline Phosphatase, TBA: Bile Acids Per G Tissue