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Hematology Individual Animal

Study Information:

Chemical Name: alpha/beta Thujone Mixture
CASRN: ="76231-76-0"
Study Number: C99037B
Study Length (Year Completed): 13 Weeks (N/A)
Exposure Route: GAV
TDMS Number: 9903798.ss
Sex: Male
Strain and Species: Fischer 344 Rats

Hematology Individual Animal Data
Measurement Time Animal Number Dose Group (mg/kg) Control Code Erythrcyt (million/uL) Hgb (g/dL) HCT (Automated) (%) HCT (spun) (%) MCV (fL) MCH (pg) MCHC (g/dL) Retics (million/uL) Retics (%) Platelet (1000/mL) Leukocytes (1000/mL) Neut (1000/mL) Lymph (1000/mL) Mono (1000/mL) EOS (1000/mL) Basophils (1000/mL) NRBC (per 100 WC) LUC (1000/mL)
Day 4 0121 0 7.30 13.9 40.8 42.0 55.9 19.0 34.0 .478 6.5 984 8.99 0.67 8.08 0.11 0.04 0.03 0 0.05
Day 4 0122 0 7.82 14.8 44.9 44.5 57.4 18.9 33.0 .585 7.5 990 9.23 0.95 8.03 0.15 0.04 0.03 0 0.05
Day 4 0123 0 7.62 14.4 43.8 44.0 57.5 18.9 32.9 .574 7.5 911 8.08 0.91 6.98 0.12 0.02 0.02 0 0.03
Day 4 0124 0 7.44 14.2 42.6 42.0 57.2 19.1 33.4 .537 7.2 1061 8.67 0.86 7.56 0.13 0.05 0.02 0 0.05
Day 4 0125 0 7.23 13.9 41.5 42.0 57.4 19.2 33.4 .474 6.5 1013 8.43 0.76 7.39 0.17 0.03 0.02 0 0.05
Day 4 0126 0 7.46 14.3 42.6 44.0 57.1 19.2 33.6 .46 6.2 1050 9.78 0.97 8.59 0.08 0.05 0.03 1 0.06
Day 4 0127 0 8.21 15.5 47.4 46.0 57.7 18.9 32.8 .631 7.7 850 10.92 0.88 9.69 0.22 0.03 0.04 0 0.06
Day 4 0128 0 8.01 15.1 45.6 44.5 56.9 18.8 33.1 .433 5.4 1001 8.84 0.73 7.85 0.16 0.03 0.03 0 0.05
Day 4 0129 0 7.72 14.5 44.4 44.0 57.5 18.8 32.8 .419 5.4 926 9.12 0.84 8.03 0.12 0.04 0.05 0 0.05
Day 4 0130 0 7.29 13.8 42.3 41.5 58.1 18.9 32.6 .607 8.3 1014 8.19 0.88 7.12 0.10 0.03 0.02 0 0.05
Day 4 0131 12.5 6.76 13.0 38.6 40.0 57.1 19.3 33.8 .526 7.8 1090 8.53 0.69 7.56 0.12 0.04 0.06 0 0.07
Day 4 0132 12.5 7.75 14.9 44.9 44.5 57.9 19.2 33.1 .521 6.7 989 7.97 0.77 6.99 0.12 0.02 0.03 0 0.03
Day 4 0133 12.5 7.49 14.1 42.6 43.0 56.9 18.8 33.1 .548 7.3 988 7.87 0.78 6.73 0.22 0.04 0.03 0 0.08
Day 4 0134 12.5 7.48 14.2 43.0 43.0 57.5 19.0 33.0 .479 6.4 930 8.53 0.80 7.50 0.13 0.02 0.03 1 0.05
Day 4 0135 12.5 7.33 13.9 42.2 42.0 57.5 19.0 32.9 .511 7.0 914 7.87 0.69 7.01 0.09 0.03 0.02 0 0.04
Day 4 0136 12.5 7.64 14.8 44.2 45.0 57.9 19.4 33.5 .448 5.9 935 7.62 0.71 6.73 0.10 0.02 0.02 0 0.05
Day 4 0137 12.5 7.77 14.7 44.1 45.0 56.8 18.9 33.3 .565 7.3 894 8.29 0.84 7.19 0.14 0.04 0.03 0 0.05
Day 4 0138 12.5 7.52 14.5 43.3 43.0 57.6 19.3 33.5 .555 7.4 1027 8.42 0.79 7.37 0.14 0.03 0.04 0 0.04
Day 4 0139 12.5 7.63 14.8 44.4 43.5 58.1 19.4 33.4 .517 6.8 950 8.27 0.74 7.33 0.10 0.02 0.03 1 0.05
Day 4 0140 12.5 7.22 14.0 41.8 42.0 57.9 19.4 33.5 .601 8.3 1020 9.20 0.98 7.98 0.15 0.04 0.02 1 0.03
Day 4 0141 25 7.02 13.7 41.0 40.0 58.4 19.5 33.3 .53 7.5 982 7.69 0.75 6.74 0.11 0.02 0.03 0 0.04
Day 4 0142 25 6.94 13.3 40.5 40.0 58.4 19.1 32.8 .541 7.8 998 8.07 0.81 7.02 0.15 0.03 0.02 1 0.04
Day 4 0143 25 7.07 13.4 40.9 41.0 57.8 19.0 32.9 .573 8.1 1029 7.06 0.90 5.95 0.12 0.03 0.03 1 0.03
Day 4 0144 25 7.78 14.7 44.3 43.0 57.0 18.9 33.2 .442 5.7 970 8.52 0.74 7.56 0.13 0.02 0.03 0 0.04
Day 4 0145 25 8.17 15.4 46.6 46.5 57.0 18.9 33.1 .511 6.3 804 8.65 0.76 7.67 0.11 0.03 0.04 0 0.06
Day 4 0146 25 7.83 15.0 44.9 45.0 57.3 19.1 33.4 .559 7.1 915 10.50 0.90 9.30 0.18 0.03 0.04 0 0.06
Day 4 0147 25 7.35 14.1 41.2 42.0 56.1 19.2 34.3 .493 6.7 948 9.10 0.88 8.02 0.11 0.02 0.03 0 0.05
Day 4 0148 25 7.42 14.3 42.3 43.5 57.0 19.3 33.8 .48 6.5 1005 9.68 0.87 8.53 0.14 0.04 0.04 0 0.06
Day 4 0149 25 7.96 13.6 44.7 44.0 56.1 17.0 30.4 .522 6.6 728 8.59 0.73 7.58 0.17 0.04 0.03 1 0.04
Day 4 0150 25 7.95 15.2 45.4 45.0 57.1 19.1 33.4 .48 6.0 909 9.09 0.76 8.15 0.07 0.04 0.03 0 0.04
Day 4 0151 50 6.86 13.3 39.3 39.5 57.3 19.4 33.9 .451 6.6 1042 6.64 0.63 5.80 0.11 0.03 0.02 0 0.05
Day 4 0152 50 7.42 14.3 42.7 42.5 57.6 19.3 33.5 .455 6.1 1055 7.75 0.72 6.83 0.09 0.02 0.03 0 0.05
Day 4 0153 50 7.68 14.9 44.5 45.0 58.0 19.4 33.4 .437 5.7 1043 9.86 0.82 8.83 0.11 0.03 0.03 0 0.04
Day 4 0154 50 7.87 14.7 45.0 45.0 57.1 18.7 32.8 .585 7.4 1060 9.72 0.94 8.52 0.12 0.04 0.04 1 0.06
Day 4 0155 50 7.22 13.9 42.0 41.5 58.1 19.3 33.2 .491 6.8 957 8.59 0.89 7.48 0.11 0.03 0.03 1 0.05
Day 4 0156 50 7.35 13.9 41.5 41.5 56.4 18.9 33.5 .478 6.5 1104 10.13 1.01 8.75 0.13 0.06 0.08 0 0.09
Day 4 0157 50 7.89 15.0 44.9 44.5 57.0 19.0 33.3 .56 7.1 900 8.52 0.67 7.57 0.20 0.03 0.02 0 0.04
Day 4 0158 50 7.29 13.8 41.7 41.5 57.3 18.9 33.0 .515 7.1 1048 8.44 0.80 7.38 0.14 0.03 0.04 0 0.05
Day 4 0159 50 7.68 14.4 44.1 43.5 57.5 18.7 32.6 .584 7.6 1131 9.43 1.01 8.22 0.10 0.03 0.04 0 0.03
Day 4 0160 50 7.42 14.1 42.5 42.5 57.3 19.0 33.2 .515 6.9 991 8.40 0.73 7.46 0.10 0.03 0.03 0 0.04
Day 4 0161 75 6.77 12.9 38.3 38.5 56.5 19.0 33.6 .506 7.5 1049 7.16 0.84 6.13 0.06 0.05 0.04 0 0.04
Day 4 0162 75 7.09 13.5 40.0 40.0 56.4 19.1 33.8 .451 6.4 907 9.18 0.84 8.05 0.15 0.05 0.04 0 0.04
Day 4 0163 75 7.91 14.9 45.1 44.5 57.0 18.8 33.1 .546 6.9 842 8.79 0.80 7.74 0.15 0.03 0.01 0 0.05
Day 4 0164 75 7.72 15.4 47.0 46.0 60.8 19.9 32.7 .686 8.9 915 7.50 0.70 6.61 0.10 0.04 0.03 1 0.03
Day 4 0165 75 7.49 14.2 42.2 42.5 56.4 18.9 33.6 .45 6.0 1018 9.86 0.93 8.64 0.14 0.05 0.06 0 0.05
Day 4 0166 75 7.43 14.1 42.8 42.5 57.6 19.0 33.0 .516 6.9 859 9.21 0.80 8.15 0.15 0.03 0.04 1 0.04
Day 4 0167 75 8.12 15.6 46.9 47.0 57.8 19.2 33.3 .479 5.9 958 9.03 0.83 7.97 0.12 0.03 0.04 0 0.04
Day 4 0168 75 7.66 14.5 43.3 43.5 56.5 18.9 33.5 .578 7.5 977 8.55 0.90 7.27 0.24 0.03 0.04 0 0.07
Day 4 0169 75 7.69 14.9 44.5 44.0 57.9 19.4 33.5 .479 6.2 923 9.08 0.80 8.05 0.13 0.03 0.03 0 0.04
Day 4 0170 75 7.69 14.4 44.1 44.0 57.3 18.7 32.6 .501 6.5 921 8.64 0.88 7.57 0.09 0.03 0.03 1 0.05
Day 4 0171 100 7.17 13.5 40.8 41.0 56.8 18.9 33.2 .475 6.6 945 9.06 0.67 8.16 0.12 0.04 0.04 0 0.04
Day 4 0172 100 7.32 14.1 41.9 42.5 57.3 19.3 33.7 .528 7.2 1028 7.71 0.82 6.60 0.19 0.03 0.03 1 0.05
Day 4 0173 100 7.63 14.7 43.7 43.0 57.2 19.3 33.7 .508 6.7 983 8.04 0.68 7.10 0.14 0.04 0.02 0 0.05
Day 4 0174 100 8.15 15.3 45.1 44.5 55.3 18.7 33.8 .293 3.6 915 11.09 0.69 10.10 0.13 0.04 0.05 0 0.07
Day 4 0175 100 7.79 14.8 44.8 44.5 57.5 19.0 33.0 .524 6.7 899 9.45 0.89 8.30 0.15 0.03 0.03 0 0.06
Day 4 0176 100 7.12 13.3 40.0 39.0 56.1 18.7 33.4 .411 5.8 835 10.03 0.98 8.67 0.19 0.05 0.06 0 0.08
Day 4 0177 100 8.03 15.1 45.6 44.5 56.8 18.8 33.2 .472 5.9 899 8.87 0.78 7.83 0.14 0.03 0.04 0 0.05
Day 4 0178 100 7.30 14.0 41.7 42.5 57.2 19.2 33.6 .543 7.4 1082 8.84 0.88 7.63 0.22 0.02 0.04 1 0.05
Day 4 0179 100 7.21 13.9 42.8 43.0 59.3 19.3 32.5 .634 8.8 952 7.42 0.81 6.40 0.12 0.02 0.03 0 0.04
Day 4 0180 100 7.55 14.5 44.4 44.5 58.8 19.2 32.7 .649 8.6 1084 7.51 0.77 6.53 0.11 0.03 0.02 2 0.05
Day 25 0121 0 7.88 15.5 44.1 45.0 56.0 19.7 35.2 .238 3.0 872 10.55 0.85 9.40 0.14 0.04 0.05 0 0.07
Day 25 0122 0 7.92 15.3 45.8 46.5 57.8 19.4 33.5 .257 3.2 964 10.04 1.22 8.51 0.18 0.06 0.02 0 0.04
Day 25 0123 0 8.15 15.3 46.0 45.0 56.4 18.8 33.3 .23 2.8 935 10.31 1.51 8.39 0.26 0.04 0.04 0 0.07
Day 25 0124 0 8.52 15.9 48.8 48.0 57.3 18.7 32.6 .236 2.8 1024 10.63 0.89 9.48 0.13 0.03 0.02 0 0.06
Day 25 0125 0 8.15 15.4 47.1 46.5 57.8 18.9 32.7 .244 3.0 909 9.54 0.76 8.56 0.12 0.04 0.03 1 0.04
Day 25 0126 0 8.20 15.5 46.4 45.5 56.6 18.9 33.4 .233 2.8 887 10.84 1.06 9.50 0.12 0.08 0.03 0 0.05
Day 25 0127 0 8.23 15.4 46.4 46.5 56.4 18.7 33.2 .257 3.1 864 11.20 0.91 9.94 0.18 0.06 0.03 0 0.08
Day 25 0128 0 8.83 16.8 50.8 51.0 57.5 19.0 33.0 .22 2.5 948 11.43 0.84 10.25 0.17 0.06 0.03 0 0.07
Day 25 0129 0 7.86 14.8 45.4 45.5 57.7 18.8 32.6 .295 3.7 986 9.70 0.89 8.63 0.08 0.06 0.02 0 0.03
Day 25 0130 0 7.96 15.1 46.9 46.0 58.9 19.0 32.3 .306 3.8 971 11.59 0.90 10.44 0.13 0.03 0.03 0 0.06
Day 25 0131 12.5 8.01 15.8 45.5 45.5 56.8 19.7 34.8 .276 3.4 974 10.79 1.04 9.49 0.14 0.05 0.03 0 0.04
Day 25 0132 12.5 7.89 14.9 44.9 44.0 57.0 18.9 33.1 .266 3.4 866 9.58 1.08 8.24 0.14 0.05 0.02 0 0.06
Day 25 0133 12.5 8.44 15.9 48.3 46.5 57.2 18.8 32.8 .307 3.6 921 9.38 0.98 8.13 0.13 0.06 0.03 0 0.05
Day 25 0134 12.5 8.29 15.4 46.2 45.0 55.7 18.6 33.3 .212 2.6 910 9.95 0.98 8.56 0.25 0.05 0.03 0 0.09
Day 25 0135 12.5 7.85 14.7 44.7 44.0 57.0 18.8 32.9 .27 3.4 899 11.32 1.19 9.87 0.15 0.04 0.02 0 0.05
Day 25 0136 12.5 7.85 15.0 46.0 46.0 58.7 19.1 32.5 .265 3.4 1019 9.93 1.08 8.55 0.19 0.04 0.02 0 0.05
Day 25 0137 12.5 7.86 14.5 43.6 44.0 55.4 18.4 33.3 .278 3.5 741 12.67 1.20 11.12 0.15 0.07 0.04 0 0.09
Day 25 0138 12.5 8.16 15.5 46.9 46.5 57.5 19.0 33.1 .304 3.7 865 11.22 1.25 9.67 0.16 0.05 0.03 0 0.05
Day 25 0139 12.5 8.29 15.5 47.8 47.5 57.7 18.7 32.5 .317 3.8 996 10.23 1.12 8.89 0.11 0.03 0.02 0 0.05
Day 25 0140 12.5 7.72 14.8 45.4 45.0 58.8 19.1 32.5 .332 4.3 921 10.39 1.10 9.02 0.13 0.06 0.03 0 0.05
Day 25 0141 25 7.87 15.9 45.5 45.0 57.8 20.2 34.9 .28 3.6 976 10.92 1.09 9.54 0.13 0.06 0.06 0 0.06
Day 25 0142 25 7.88 15.0 44.5 43.0 56.5 19.1 33.8 .283 3.6 1000 10.22 1.12 8.80 0.18 0.07 0.03 0 0.03
Day 25 0143 25 8.15 15.6 47.0 46.5 57.6 19.2 33.3 .295 3.6 925 9.78 1.09 8.46 0.15 0.03 0.02 0 0.03
Day 25 0144 25 8.19 15.3 46.3 44.5 56.5 18.7 33.1 .25 3.1 929 9.52 1.00 8.08 0.26 0.06 0.03 0 0.09
Day 25 0145 25 8.29 15.7 47.2 46.5 56.9 18.9 33.2 .302 3.6 970 9.31 0.84 8.23 0.13 0.05 0.02 0 0.05
Day 25 0146 25 8.01 15.2 46.0 45.0 57.4 19.0 33.0 .262 3.3 883 11.59 1.05 10.27 0.12 0.05 0.03 0 0.06
Day 25 0147 25 8.14 15.3 46.1 45.5 56.6 18.8 33.3 .257 3.2 913 11.69 1.19 10.14 0.19 0.07 0.03 0 0.09
Day 25 0148 25 7.93 15.3 45.4 44.5 57.2 19.3 33.7 .303 3.8 783 11.18 1.09 9.63 0.26 0.08 0.04 1 0.09
Day 25 0149 25 8.43 15.7 47.5 46.0 56.4 18.6 32.9 .327 3.9 843 10.71 0.96 9.45 0.14 0.08 0.03 0 0.05
Day 25 0150 25 7.66 14.3 44.0 43.5 57.5 18.7 32.6 .352 4.6 836 9.20 0.88 8.11 0.09 0.06 0.02 0 0.04
Day 25 0151 50 7.91 15.2 45.1 45.0 57.0 19.2 33.6 .25 3.2 858 10.50 1.13 9.07 0.15 0.04 0.04 0 0.06
Day 25 0152 50 8.10 15.4 45.4 44.0 56.0 19.0 34.0 .209 2.6 878 10.84 1.12 9.43 0.16 0.06 0.02 0 0.04
Day 25 0153 50 8.22 15.4 46.9 46.0 57.0 18.7 32.8 .278 3.4 942 11.62 1.35 9.88 0.20 0.07 0.05 0 0.07
Day 25 0154 50 7.98 15.0 44.9 44.5 56.3 18.8 33.4 .299 3.7 1005 10.84 1.15 9.25 0.27 0.05 0.04 0 0.09
Day 25 0155 50 7.85 15.0 46.3 46.0 59.0 19.1 32.3 .303 3.9 1047 9.42 0.99 8.15 0.15 0.07 0.02 0 0.05
Day 25 0156 50 7.88 15.0 44.6 45.0 56.7 19.0 33.5 .245 3.1 811 11.12 0.98 9.84 0.14 0.06 0.04 0 0.05
Day 25 0157 50 7.77 14.8 44.1 44.5 56.8 19.0 33.5 .262 3.4 882 11.18 1.36 9.48 0.15 0.08 0.03 0 0.08
Day 25 0158 50 8.17 15.4 46.4 45.5 56.8 18.9 33.2 .328 4.0 853 11.40 1.40 9.69 0.18 0.07 0.03 0 0.04
Day 25 0159 50 8.21 15.4 46.8 47.0 57.0 18.8 32.9 .26 3.2 891 10.47 1.02 9.16 0.15 0.06 0.04 0 0.03
Day 25 0160 50 8.37 15.6 47.3 45.0 56.5 18.7 33.1 .303 3.6 836 10.61 0.95 9.25 0.17 0.12 0.04 0 0.09
Day 25 0161 75 7.89 15.0 44.4 44.0 56.3 19.0 33.8 .225 2.8 906 10.74 0.91 9.53 0.15 0.06 0.03 0 0.05
Day 25 0162 75 8.08 15.4 45.8 45.0 56.7 19.0 33.6 .266 3.3 998 12.94 1.28 11.25 0.22 0.07 0.05 0 0.08
Day 25 0163 75 7.69 14.7 44.2 44.0 57.5 19.1 33.2 .269 3.5 892 10.48 1.16 8.94 0.16 0.07 0.03 0 0.12
Day 25 0164 75 7.73 15.6 47.0 45.0 60.7 20.2 33.2 .309 4.0 888 10.05 1.06 8.60 0.21 0.09 0.02 0 0.06
Day 25 0165 75 8.27 15.2 45.8 44.0 55.4 18.4 33.2 .264 3.2 931 11.06 1.10 9.63 0.13 0.09 0.04 0 0.07
Day 25 0166 75 7.87 14.9 45.1 44.5 57.3 18.9 33.1 .287 3.6 938 11.09 1.33 9.44 0.17 0.07 0.05 0 0.04
Day 25 0167 75 8.03 15.2 46.1 45.5 57.4 18.9 33.0 .257 3.2 885 9.96 1.35 8.28 0.16 0.08 0.03 0 0.06
Day 25 0168 75 8.29 15.6 47.4 47.0 57.2 18.8 32.9 .294 3.6 871 9.77 1.17 8.32 0.16 0.05 0.03 0 0.04
Day 25 0169 75 8.32 15.5 47.1 45.5 56.6 18.6 32.8 .247 3.0 890 9.35 1.23 7.85 0.10 0.07 0.02 0 0.08
Day 25 0170 75 8.11 15.2 46.0 45.5 56.8 18.7 33.0 .318 3.9 866 9.36 1.20 7.80 0.22 0.07 0.02 0 0.05
Day 25 0171 100 7.82 15.6 44.1 44.5 56.4 19.9 35.4 .315 4.0 976 11.24 0.98 9.96 0.13 0.07 0.03 0 0.07
Day 25 0172 100 7.86 15.1 44.2 44.0 56.2 19.2 34.1 .27 3.4 964 11.20 0.97 9.90 0.16 0.06 0.03 0 0.08
Day 25 0173 100 8.15 15.4 46.6 47.5 57.2 18.9 33.1 .249 3.1 895 10.94 1.15 9.43 0.21 0.08 0.02 0 0.05
Day 25 0174 100 8.75 15.7 47.9 46.0 54.8 18.0 32.8 .289 3.3 884 11.06 1.00 9.73 0.17 0.08 0.02 0 0.06
Day 25 0175 100 8.10 15.1 46.5 46.5 57.4 18.7 32.5 .299 3.7 718 9.34 0.99 8.12 0.10 0.04 0.02 0 0.06
Day 25 0176 100 8.08 15.2 45.9 44.0 56.9 18.8 33.1 .266 3.3 932 10.77 1.06 9.45 0.13 0.05 0.02 0 0.06
Day 25 0177 100 8.67 16.0 48.9 48.0 56.4 18.4 32.7 .199 2.3 802 11.11 1.09 9.76 0.13 0.04 0.03 0 0.05
Day 25 0178 100 8.08 15.4 46.4 46.5 57.4 19.0 33.1 .286 3.5 982 10.59 1.09 9.22 0.14 0.06 0.03 0 0.05
Day 25 0179 100 7.92 15.3 46.3 44.5 58.4 19.4 33.1 .254 3.2 938 10.15 0.94 8.93 0.14 0.06 0.03 0 0.05
Day 25 0180 100 7.94 15.4 46.8 46.5 59.0 19.4 32.8 .375 4.7 1052 13.02 1.06 11.40 0.34 0.06 0.04 0 0.10
Abbreviations:
NA: Not Available, Erythrcyt: Red Blood Cell Count, Hgb: Hemoglobin, HCT (Automated): Hematocrit, HCT (spun): Hematocrit Manual, MCV: Mean Corpuscular Volume, MCH: Mean Cell Hemoglobin, MCHC: Mean Cell Hemoglobin Concentration, Retics: Reticulocyte Count, Retics: Reticulocyte Percentage, Platelet: Platelet Count, Leukocytes: White Blood Cell Count, Neut: Neutrophil Count, Lymph: Lymphocyte Count, Mono: Monocyte Count, EOS: Eosinophil Count, Basophils: Basophil Count, NRBC: Nucleated Rbc Per 100 Wbc, LUC: Large Unstained Cells Count