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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: 1,2-Dichlorobenzene (o-dichlorobenzene)
CASRN: ="95-50-1"
Study Number: C54944A
Exposure Route: Gavage
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Perirectal Tissue, Rectum Vehicle Control NA NA 3_031 112.00 1 Squamous Cell Carcinoma Scheduled Sacrifice
Alimentary System Intestine Small Mesentery Nos Vehicle Control NA NA 3_028 112.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver Vehicle Control 48 NA 3_033 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Vehicle Control 48 NA 3_042 112.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver Vehicle Control 48 NA 3_009 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 48 NA 3_019 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 48 NA 3_029 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 47 NA 2_002 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 47 NA 2_005 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 47 NA 2_006 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 47 NA 2_021 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 47 NA 2_044 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 46 NA 1_010 112.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 46 NA 1_031 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 46 NA 1_035 112.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Pancreas Islets Vehicle Control 46 NA 3_047 112.00 1 Islet-Cell Adenoma Moribund Sacrifice
All Others Unspecified Leg 060.0 MG/KG NA NA 2_024 112.00 1 Basal-Cell Carcinoma Natural Death
All Others Unspecified Leg 120.0 MG/KG NA NA 1_009 112.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_025 112.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_032 112.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_033 112.00 1 Lymphoma, Undifferentiated-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_003 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_012 112.00 1 Lymphoma, Undifferentiated-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_021 112.00 1 Leukemia, Lymphocytic Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_049 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_007 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_011 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_017 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_019 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_022 112.00 1 Leukemia, Lymphocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_045 112.00 1 Lymphoma, Undifferentiated-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_025 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_034 112.00 1 Leukemia, Undifferentiated Natural Death
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_043 112.00 1 Carcinoma, Nos, Uncertain Primary Or Metastatic Natural Death
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_048 112.00 1 Leukemia, Lymphocytic Natural Death
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_004 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_006 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_009 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_022 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_023 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_026 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_046 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_006 112.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_005 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_009 112.00 1 Sarcoma, Nos, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_011 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_015 112.00 1 Leukemia, Lymphocytic Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_038 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_039 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_002 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_018 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_023 112.00 1 Lymphoma, Undifferentiated-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_024 112.00 1 Hemangiosarcoma Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_025 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_029 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_040 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_047 112.00 1 Lymphoma, Mixed-Malignant Type Scheduled Sacrifice
All Others Unspecified Vehicle Control NA NA 3_013 112.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Vehicle Control NA NA 3_037 112.00 1 Sarcoma, Nos Natural Death
Endocrine System Adrenal gland Capsule Vehicle Control 48 NA 3_037 112.00 1 Sarcoma, Nos, Metastatic Natural Death
Endocrine System Adrenal gland Capsule 060.0 MG/KG 48 NA 2_041 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Adrenal gland Capsule 120.0 MG/KG 46 NA 1_004 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Adrenal gland Vehicle Control 48 NA 3_007 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 060.0 MG/KG 48 NA 2_021 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Adrenal gland 120.0 MG/KG 46 NA 1_003 112.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Parathyroid gland Vehicle Control 23 NA 3_050 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 39 NA 3_001 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 39 NA 3_005 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 39 NA 3_006 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 39 NA 3_010 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 39 NA 3_019 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 39 NA 3_020 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 39 NA 3_035 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 060.0 MG/KG 39 NA 2_043 112.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland 060.0 MG/KG 39 NA 2_003 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 060.0 MG/KG 39 NA 2_015 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 060.0 MG/KG 39 NA 2_038 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 120.0 MG/KG 41 NA 1_025 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 120.0 MG/KG 41 NA 1_027 112.00 1 Carcinoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 120.0 MG/KG 41 NA 1_034 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 120.0 MG/KG 41 NA 1_043 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Thyroid Vehicle Control 43 NA 3_019 112.00 1 Papillary Cystadenoma, Nos Scheduled Sacrifice
Endocrine System Thyroid 060.0 MG/KG 44 NA 2_014 112.00 1 Papillary Adenoma Scheduled Sacrifice
Endocrine System Thyroid 120.0 MG/KG 42 NA 1_016 112.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Genital System Ovary 060.0 MG/KG 44 NA 2_043 112.00 1 Hemangioma Natural Death
Genital System Ovary 120.0 MG/KG 43 NA 1_007 112.00 1 Choriocarcinoma Natural Death
Genital System Uterus Serosa 060.0 MG/KG 47 NA 2_044 112.00 1 Hemangioma Scheduled Sacrifice
Genital System Uterus Vehicle Control 48 NA 3_032 112.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Genital System Uterus Vehicle Control 48 NA 3_018 112.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 120.0 MG/KG 49 NA 1_009 112.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus 120.0 MG/KG 49 NA 1_012 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Genital System Uterus 120.0 MG/KG 49 NA 1_029 112.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Genital System Uterus 120.0 MG/KG 49 NA 1_034 112.00 1 Hemangioma Scheduled Sacrifice
Hematopoietic System Lymph node Inguinal Lymph Node Vehicle Control 41 NA 3_013 112.00 1 Sarcoma, Nos, Metastatic Natural Death
Hematopoietic System Lymph node Mesenteric Lymph Node Vehicle Control 44 NA 3_037 112.00 1 Sarcoma, Nos, Metastatic Natural Death
Hematopoietic System Lymph node Mesenteric Lymph Node 120.0 MG/KG 47 NA 1_013 112.00 1 Lymphoma, Undifferentiated-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen Follicles 060.0 MG/KG 46 NA 2_037 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen Follicles 060.0 MG/KG 46 NA 2_040 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen Vehicle Control 45 NA 3_042 112.00 1 Hemangiosarcoma Natural Death
Hematopoietic System Spleen Vehicle Control 45 NA 3_048 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Spleen 060.0 MG/KG 46 NA 2_012 112.00 1 Lymphoma, Lymphocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen 120.0 MG/KG 47 NA 1_018 112.00 1 Hemangiosarcoma Scheduled Sacrifice
Integumentary System Mammary gland 060.0 MG/KG 16 NA 2_017 112.00 1 Adenocarcinoma, Nos Scheduled Sacrifice
Nervous System Brain Thalamus 120.0 MG/KG 49 NA 1_027 112.00 1 Carcinoma, Nos, Invasive Scheduled Sacrifice
Respiratory System Lung Vehicle Control 47 NA 3_023 112.00 1 Alveolar/Bronchiolar Adenoma Moribund Sacrifice
Respiratory System Lung Vehicle Control 47 NA 3_013 112.00 1 Sarcoma, Nos, Metastatic Natural Death
Respiratory System Lung Vehicle Control 47 NA 3_015 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Vehicle Control 47 NA 3_045 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 060.0 MG/KG 48 NA 2_024 112.00 1 Basal-Cell Carcinoma, Metastatic Natural Death
Respiratory System Lung 060.0 MG/KG 48 NA 2_015 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 060.0 MG/KG 48 NA 2_016 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 060.0 MG/KG 48 NA 2_022 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 060.0 MG/KG 48 NA 2_042 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 48 NA 1_002 112.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 48 NA 1_010 112.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 48 NA 1_017 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 48 NA 1_036 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Special Senses System Eye Lacrimal Gland Vehicle Control 2 NA 3_023 112.00 1 Squamous Cell Carcinoma Moribund Sacrifice
Special Senses System Eye Lacrimal Gland 060.0 MG/KG 2 NA 2_007 112.00 1 Papillary Cystadenoma, Nos Scheduled Sacrifice