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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: 2,4- & 2,6-Toluene diisocyanate
CASRN: ="26471-62-5"
Study Number: C50533
Exposure Route: Gavage
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Cecum, Colon Vehicle Control 45 NA 4_022 118.00 1 Leiomyosarcoma Natural Death
Alimentary System Intestine Small Duodenum Untreated Control 48 NA 3_013 87.00 1 Adenomatous Polyp, Nos Scheduled Sacrifice
Alimentary System Intestine Small Duodenum 120.0 MG/KG 41 NA 1_007 118.00 1 Papillary Adenoma Scheduled Sacrifice
Alimentary System Intestine Small Jejunum 060.0 MG/KG 3 NA 2_010 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Alimentary System Liver Vehicle Control 50 NA 4_042 118.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Vehicle Control 50 NA 4_005 118.00 1 Hepatocellular Adenoma Natural Death
Alimentary System Liver Vehicle Control 50 NA 4_022 118.00 1 Sarcoma, Nos, Metastatic Natural Death
Alimentary System Liver Vehicle Control 50 NA 4_007 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 50 NA 4_009 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 50 NA 2_013 118.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver 060.0 MG/KG 50 NA 2_001 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 50 NA 2_032 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 50 NA 2_035 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 060.0 MG/KG 50 NA 2_050 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_018 118.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver 120.0 MG/KG 50 NA 1_030 118.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 120.0 MG/KG 50 NA 1_008 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_009 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_010 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_011 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_021 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_023 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_024 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_028 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_037 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_041 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_042 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_044 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_049 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 50 NA 1_050 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
All Others Unspecified Abdominal Cavity 120.0 MG/KG NA NA 1_030 118.00 1 Hemangiosarcoma Natural Death
All Others Unspecified Axilla 120.0 MG/KG NA NA 1_004 118.00 1 Hemangioma Natural Death
All Others Unspecified Leg Vehicle Control NA NA 4_022 118.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Mediastinum Nos Vehicle Control NA NA 4_033 118.00 1 Osteosarcoma, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_006 118.00 1 Lymphoma, Nos-Malignant Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_012 87.00 1 Leukemia, Lymphocytic Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_002 118.00 1 Leukemia, Nos Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_010 118.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_021 118.00 1 Leukemia, Nos Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_036 118.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_037 118.00 1 Leukemia, Nos Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_030 87.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_043 87.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_049 87.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_012 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_017 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_019 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_038 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_045 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_050 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_049 118.00 1 Lymphoma, Nos-Malignant Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_047 118.00 1 Fibrosarcoma, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_006 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_012 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_020 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_021 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_027 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_029 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_031 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_032 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_033 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_035 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_037 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_045 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 2_050 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_001 118.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_004 118.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_029 118.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_002 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_003 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_008 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_015 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_023 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_024 118.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_031 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_038 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_042 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_047 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 1_050 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified 120.0 MG/KG NA NA 1_041 118.00 1 Hemangioma Scheduled Sacrifice
Endocrine System Adrenal gland 060.0 MG/KG 49 NA 2_016 118.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 46 NA 3_014 87.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Vehicle Control 46 NA 4_013 118.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Vehicle Control 46 NA 4_009 118.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 46 NA 4_028 118.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Vehicle Control 46 NA 4_030 118.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 060.0 MG/KG 44 NA 2_005 118.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 060.0 MG/KG 44 NA 2_018 118.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 060.0 MG/KG 44 NA 2_026 118.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 120.0 MG/KG 43 NA 1_037 118.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Thyroid Vehicle Control 44 NA 4_005 118.00 1 Follicular-Cell Adenoma Natural Death
Endocrine System Thyroid 060.0 MG/KG 44 NA 2_018 118.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Genital System Ovary 120.0 MG/KG 48 NA 1_029 118.00 1 Hemangiosarcoma Natural Death
Genital System Ovary 120.0 MG/KG 48 NA 1_022 118.00 1 Teratoma, Nos Scheduled Sacrifice
Genital System Uterus Vehicle Control 50 NA 4_020 118.00 1 Endometrial Stromal Sarcoma Scheduled Sacrifice
Genital System Uterus 060.0 MG/KG 50 NA 2_025 118.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 060.0 MG/KG 50 NA 2_039 118.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 120.0 MG/KG 50 NA 1_006 118.00 1 Leiomyoma Natural Death
Hematopoietic System Lymph node Inguinal Lymph Node Vehicle Control 45 NA 4_048 118.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Lymph node Mediastinal Lymph Node 060.0 MG/KG 44 NA 2_038 118.00 1 Alveolar/Bronchiolar Carcinoma, Metastatic Scheduled Sacrifice
Hematopoietic System Lymph node Mediastinal Lymph Node 120.0 MG/KG 44 NA 1_006 118.00 1 Osteosarcoma, Metastatic Natural Death
Hematopoietic System Lymph node Mediastinal Lymph Node 120.0 MG/KG 44 NA 1_007 118.00 1 Osteosarcoma, Uncertain Primary/Metastatic Scheduled Sacrifice
Hematopoietic System Lymph node Mediastinal Lymph Node 120.0 MG/KG 44 NA 1_025 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node 060.0 MG/KG 48 NA 2_002 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node 060.0 MG/KG 48 NA 2_040 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Hematopoietic System Spleen 060.0 MG/KG 50 NA 2_019 118.00 1 Hemangioma Scheduled Sacrifice
Hematopoietic System Thymus 120.0 MG/KG 40 NA 1_013 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 47 NA 3_045 87.00 1 Adenoma, Nos Scheduled Sacrifice
Integumentary System Mammary gland 060.0 MG/KG 41 NA 2_024 118.00 1 Carcinosarcoma Scheduled Sacrifice
Integumentary System Mammary gland 120.0 MG/KG 43 NA 1_018 118.00 1 Adenocarcinoma, Nos Natural Death
Integumentary System Skin 060.0 MG/KG 48 NA 2_047 118.00 1 Fibrosarcoma Natural Death
Integumentary System Skin 120.0 MG/KG 50 NA 1_009 118.00 1 Myxosarcoma Scheduled Sacrifice
Integumentary System Skin 120.0 MG/KG 50 NA 1_037 118.00 1 Fibrosarcoma Scheduled Sacrifice
Musculoskeletal System Bone Rib Vehicle Control NA NA 4_033 118.00 1 Osteosarcoma Natural Death
Musculoskeletal System Bone Vertebral Column Vehicle Control NA NA 4_029 118.00 1 Osteosarcoma Accidently Killed
Musculoskeletal System Bone Vertebral Column Vehicle Control NA NA 4_039 118.00 1 Osteosarcoma Natural Death
Musculoskeletal System Bone Vehicle Control NA NA 4_049 118.00 1 Osteosarcoma Natural Death
Musculoskeletal System Bone 120.0 MG/KG NA NA 1_006 118.00 1 Osteosarcoma Natural Death
Respiratory System Lung Vehicle Control 49 NA 4_029 118.00 1 Osteosarcoma, Metastatic Accidently Killed
Respiratory System Lung Vehicle Control 49 NA 4_042 118.00 1 Hepatocellular Carcinoma, Metastatic Moribund Sacrifice
Respiratory System Lung Vehicle Control 49 NA 4_022 118.00 1 Sarcoma, Nos, Metastatic Natural Death
Respiratory System Lung Vehicle Control 49 NA 4_033 118.00 1 Osteosarcoma, Metastatic Natural Death
Respiratory System Lung Vehicle Control 49 NA 4_039 118.00 1 Osteosarcoma, Metastatic Natural Death
Respiratory System Lung Vehicle Control 49 NA 4_049 118.00 1 Osteosarcoma, Metastatic Natural Death
Respiratory System Lung 060.0 MG/KG 50 NA 2_038 118.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 060.0 MG/KG 50 NA 2_042 118.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 060.0 MG/KG 50 NA 2_044 118.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 50 NA 1_006 118.00 1 Osteosarcoma, Metastatic Natural Death
Respiratory System Lung 120.0 MG/KG 50 NA 1_007 118.00 1 Osteosarcoma, Uncertain Primary/Metastatic Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 50 NA 1_023 118.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland Vehicle Control NA NA 4_037 118.00 1 Adenoma, Nos Natural Death
Special Senses System Harderian gland Hardarian Gland 060.0 MG/KG NA NA 2_039 118.00 1 Adenoma, Nos Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland 120.0 MG/KG NA NA 1_044 118.00 1 Adenoma, Nos Scheduled Sacrifice
Urinary System Kidney Vehicle Control 50 NA 4_029 118.00 1 Osteosarcoma, Metastatic Accidently Killed