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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: 2,4- & 2,6-Toluene diisocyanate
CASRN: ="26471-62-5"
Study Number: C50533
Exposure Route: Gavage
TDMS Number:
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Duodenum Vehicle Control 46 NA 4_025 118.00 1 Papilloma, Nos Scheduled Sacrifice
Alimentary System Intestine Small Duodenum 120.0 MG/KG 44 NA 2_005 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Alimentary System Intestine Small Jejunum Vehicle Control 1 NA 4_003 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_001 87.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_019 87.00 1 Lipoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_028 87.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_030 87.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_031 87.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_039 87.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_039 87.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_040 87.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_042 87.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_049 87.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_049 87.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_006 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_008 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_015 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_019 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_021 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_026 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_031 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_033 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_041 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_048 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 49 NA 4_049 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_023 118.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 120.0 MG/KG 48 NA 2_026 118.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 120.0 MG/KG 48 NA 2_042 118.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 120.0 MG/KG 48 NA 2_001 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_016 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_019 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_029 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_030 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_038 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_041 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_047 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 120.0 MG/KG 48 NA 2_048 118.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 240.0 MG/KG 50 NA 1_002 118.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 240.0 MG/KG 50 NA 1_016 118.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
Alimentary System Liver 240.0 MG/KG 50 NA 1_038 118.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 240.0 MG/KG 50 NA 1_039 118.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 240.0 MG/KG 50 NA 1_026 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 240.0 MG/KG 50 NA 1_027 118.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Pancreas Islets 120.0 MG/KG 47 NA 2_002 118.00 1 Islet-Cell Carcinoma Scheduled Sacrifice
Alimentary System Stomach Forestomach Vehicle Control 48 NA 4_032 118.00 1 Papilloma, Nos Scheduled Sacrifice
All Others Unspecified Axilla Vehicle Control NA NA 4_027 118.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Groin Untreated Control NA NA 3_005 87.00 1 Fibrosarcoma Natural Death
All Others Unspecified Groin Vehicle Control NA NA 4_030 118.00 1 Fibrosarcoma Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_012 87.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_005 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_032 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_044 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 2_024 118.00 1 Fibrosarcoma, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 2_037 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 120.0 MG/KG NA NA 2_043 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 240.0 MG/KG NA NA 1_007 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 240.0 MG/KG NA NA 1_013 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Endocrine System Adrenal gland Vehicle Control 49 NA 4_006 118.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Adrenal gland 120.0 MG/KG 48 NA 2_014 118.00 1 Cortical Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 120.0 MG/KG 42 NA 2_028 118.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Thyroid 120.0 MG/KG 39 NA 2_044 118.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Endocrine System Thyroid 240.0 MG/KG 44 NA 1_039 118.00 1 Follicular-Cell Adenoma Natural Death
Genital System Epididymis Vehicle Control 49 NA 4_016 118.00 1 Hemangiosarcoma Scheduled Sacrifice
Genital System Testis 120.0 MG/KG 49 NA 2_008 118.00 1 Interstitial-Cell Tumor Scheduled Sacrifice
Hematopoietic System Lymph node Mediastinal Lymph Node Vehicle Control 41 NA 4_016 118.00 1 Alveolar/Bronchiolar Carcinoma, Metastatic Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node Vehicle Control 50 NA 4_004 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node Vehicle Control 50 NA 4_041 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Hematopoietic System Spleen 120.0 MG/KG 47 NA 2_030 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Hematopoietic System Spleen 120.0 MG/KG 47 NA 2_044 118.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Integumentary System Skin Chest 120.0 MG/KG 49 NA 2_021 118.00 1 Fibrosarcoma Natural Death
Integumentary System Skin Groin 120.0 MG/KG 49 NA 2_021 118.00 1 Neurofibroma Natural Death
Integumentary System Skin Untreated Control 49 NA 3_044 87.00 1 Fibrosarcoma Moribund Sacrifice
Integumentary System Skin Vehicle Control 50 NA 4_007 118.00 1 Fibroma Scheduled Sacrifice
Integumentary System Skin Vehicle Control 50 NA 4_008 118.00 1 Fibroma Scheduled Sacrifice
Integumentary System Skin 120.0 MG/KG 49 NA 2_024 118.00 1 Fibrosarcoma Natural Death
Integumentary System Skin 120.0 MG/KG 49 NA 2_009 118.00 1 Fibrosarcoma Scheduled Sacrifice
Integumentary System Skin 120.0 MG/KG 49 NA 2_048 118.00 1 Fibrosarcoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 47 NA 3_045 87.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 47 NA 3_046 87.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Vehicle Control 50 NA 4_014 118.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Vehicle Control 50 NA 4_016 118.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung Vehicle Control 50 NA 4_021 118.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung Vehicle Control 50 NA 4_041 118.00 1 Hepatocellular Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 48 NA 2_010 118.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung 120.0 MG/KG 48 NA 2_026 118.00 1 Hepatocellular Carcinoma, Metastatic Natural Death
Respiratory System Lung 120.0 MG/KG 48 NA 2_016 118.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 48 NA 2_032 118.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 48 NA 2_035 118.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 120.0 MG/KG 48 NA 2_044 118.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 240.0 MG/KG 49 NA 1_010 118.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 240.0 MG/KG 49 NA 1_026 118.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland Vehicle Control NA NA 4_027 118.00 1 Adenoma, Nos Natural Death
Special Senses System Harderian gland Hardarian Gland Vehicle Control NA NA 4_031 118.00 1 Adenoma, Nos Scheduled Sacrifice
Urinary System Kidney 120.0 MG/KG 48 NA 2_012 118.00 1 Tubular-Cell Adenoma Scheduled Sacrifice