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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: 4-Chloro-o-phenylenediamine
CASRN: ="95-83-0"
Study Number: C03292
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Female
Strain and Species: F344 Rats

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver 10000 PPM 46 NA 2_030 112.00 1 Neoplastic Nodule Moribund Sacrifice
Alimentary System Liver 10000 PPM 46 NA 2_025 112.00 1 Neoplastic Nodule Scheduled Sacrifice
Alimentary System Stomach 10000 PPM 46 NA 2_030 112.00 1 Squamous Cell Papilloma Moribund Sacrifice
Alimentary System Stomach 10000 PPM 46 NA 2_018 112.00 1 Squamous Cell Papilloma Scheduled Sacrifice
Alimentary System Stomach 10000 PPM 46 NA 2_027 112.00 1 Basal-Cell Carcinoma Scheduled Sacrifice
Alimentary System Stomach 10000 PPM 46 NA 2_032 112.00 1 Squamous Cell Carcinoma Scheduled Sacrifice
Alimentary System Stomach 10000 PPM 46 NA 2_042 112.00 1 Squamous Cell Papilloma Scheduled Sacrifice
All Others Unspecified Ear 5000 PPM NA NA 1_018 112.00 1 Leiomyosarcoma Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_045 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_047 112.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_009 112.00 1 Leukemia, Undifferentiated Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_020 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_032 112.00 1 Leukemia, Undifferentiated Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_039 112.00 1 Leukemia, Myelomonocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_041 112.00 1 Leukemia, Myelomonocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_046 112.00 1 Leukemia, Myelomonocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 2_033 112.00 1 Leukemia, Myelomonocytic Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 2_013 112.00 1 Leukemia, Myelomonocytic Natural Death
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 2_002 112.00 1 Leukemia, Myelomonocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 2_020 112.00 1 Leukemia, Myelomonocytic Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 2_040 112.00 1 Leukemia, Myelomonocytic Scheduled Sacrifice
All Others Unspecified Untreated Control NA NA 3_029 112.00 1 Sarcoma, Nos Scheduled Sacrifice
All Others Unspecified 10000 PPM NA NA 2_039 112.00 1 Squamous Cell Carcinoma Natural Death
Endocrine System Adrenal gland Cortex Nos 5000 PPM 47 NA 1_049 112.00 1 Lipoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 48 NA 3_004 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 48 NA 3_022 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 48 NA 3_024 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 48 NA 3_029 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 48 NA 3_031 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 48 NA 3_035 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 5000 PPM 47 NA 1_018 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 5000 PPM 47 NA 1_027 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 10000 PPM 46 NA 2_017 112.00 1 Pheochromocytoma Moribund Sacrifice
Endocrine System Adrenal gland 10000 PPM 46 NA 2_038 112.00 1 Pheochromocytoma Moribund Sacrifice
Endocrine System Adrenal gland 10000 PPM 46 NA 2_013 112.00 1 Pheochromocytoma Natural Death
Endocrine System Adrenal gland 10000 PPM 46 NA 2_044 112.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_006 112.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Untreated Control 40 NA 3_001 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_003 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_010 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_011 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_014 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_015 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_017 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_019 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_028 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_031 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_034 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_036 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_038 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_048 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_049 112.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 40 NA 3_050 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_001 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_007 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_008 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_012 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_018 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_024 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_025 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_026 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_028 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_030 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_039 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_040 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_041 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_046 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 5000 PPM 38 NA 1_050 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 10000 PPM 38 NA 2_015 112.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland 10000 PPM 38 NA 2_005 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 10000 PPM 38 NA 2_009 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 10000 PPM 38 NA 2_010 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 10000 PPM 38 NA 2_019 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 10000 PPM 38 NA 2_037 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Pituitary gland 10000 PPM 38 NA 2_044 112.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Thyroid 5000 PPM 45 NA 1_003 112.00 1 C-Cell Carcinoma Scheduled Sacrifice
Endocrine System Thyroid 5000 PPM 45 NA 1_018 112.00 1 Follicular-Cell Carcinoma Scheduled Sacrifice
Endocrine System Thyroid 5000 PPM 45 NA 1_043 112.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Endocrine System Thyroid 10000 PPM 44 NA 2_011 112.00 1 C-Cell Carcinoma Moribund Sacrifice
Endocrine System Thyroid 10000 PPM 44 NA 2_030 112.00 1 Follicular-Cell Carcinoma Moribund Sacrifice
Endocrine System Thyroid 10000 PPM 44 NA 2_008 112.00 1 C-Cell Carcinoma Scheduled Sacrifice
Endocrine System Thyroid 10000 PPM 44 NA 2_018 112.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Endocrine System Thyroid 10000 PPM 44 NA 2_037 112.00 1 Follicular-Cell Carcinoma Scheduled Sacrifice
Endocrine System Thyroid 10000 PPM 44 NA 2_048 112.00 1 Follicular-Cell Carcinoma Scheduled Sacrifice
Genital System Clitoral gland 5000 PPM NA NA 1_005 112.00 1 Adenoma, Nos Scheduled Sacrifice
Genital System Uterus Untreated Control 48 NA 3_003 112.00 1 Fibroma Scheduled Sacrifice
Genital System Uterus Untreated Control 48 NA 3_017 112.00 1 Adenocarcinoma, Nos Scheduled Sacrifice
Genital System Uterus Untreated Control 48 NA 3_022 112.00 1 Endometrial Stromal Sarcoma Scheduled Sacrifice
Genital System Uterus Untreated Control 48 NA 3_028 112.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus Untreated Control 48 NA 3_035 112.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus Untreated Control 48 NA 3_043 112.00 1 Endometrial Stromal Sarcoma Scheduled Sacrifice
Genital System Uterus Untreated Control 48 NA 3_048 112.00 1 Fibroma Scheduled Sacrifice
Genital System Uterus 5000 PPM 49 NA 1_042 112.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus 5000 PPM 49 NA 1_007 112.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 5000 PPM 49 NA 1_034 112.00 1 Fibroma Scheduled Sacrifice
Genital System Uterus 10000 PPM 46 NA 2_017 112.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Hematopoietic System Spleen Untreated Control 50 NA 3_027 112.00 1 Leukemia, Myelomonocytic Moribund Sacrifice
Hematopoietic System Spleen Untreated Control 50 NA 3_050 112.00 1 Leukemia, Myelomonocytic Scheduled Sacrifice
Hematopoietic System Spleen 10000 PPM 46 NA 2_032 112.00 1 Squamous Cell Carcinoma, Metastatic Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 16 NA 3_010 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 16 NA 3_011 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 16 NA 3_014 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 16 NA 3_016 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 16 NA 3_024 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 16 NA 3_049 112.00 1 Adenocarcinoma, Nos Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 16 NA 3_049 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_008 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_016 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_022 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_025 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_028 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_030 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_031 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_034 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_043 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 5000 PPM 21 NA 1_049 112.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 10000 PPM 18 NA 2_033 112.00 1 Adenoma, Nos Moribund Sacrifice
Integumentary System Mammary gland 10000 PPM 18 NA 2_013 112.00 1 Adenoma, Nos Natural Death
Integumentary System Zymbal gland 10000 PPM NA NA 2_016 112.00 1 Squamous Cell Carcinoma Moribund Sacrifice
Nervous System Brain 10000 PPM 46 NA 2_018 112.00 1 Astrocytoma Scheduled Sacrifice
Respiratory System Lung 5000 PPM 49 NA 1_018 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 5000 PPM 49 NA 1_026 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 5000 PPM 49 NA 1_040 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 5000 PPM 49 NA 1_049 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 5000 PPM 49 NA 1_050 112.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_001 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_005 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_007 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_014 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_015 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_019 112.00 1 Papillary Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_022 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_023 112.00 1 Papilloma, Nos Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_024 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_028 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_029 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_030 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_036 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_041 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 5000 PPM NA NA 1_045 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_007 112.00 1 Transitional-Cell Carcinoma Moribund Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_011 112.00 1 Transitional-Cell Carcinoma Moribund Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_015 112.00 1 Papillomatosis Moribund Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_016 112.00 1 Transitional-Cell Carcinoma Moribund Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_017 112.00 1 Transitional-Cell Carcinoma Moribund Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_030 112.00 1 Transitional-Cell Carcinoma Moribund Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_033 112.00 1 Transitional-Cell Carcinoma Moribund Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_046 112.00 1 Transitional-Cell Carcinoma Natural Death
Urinary System Urinary bladder 10000 PPM NA NA 2_005 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_006 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_009 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_010 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_018 112.00 1 Papillomatosis Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_019 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_020 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_021 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_022 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_025 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_027 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_028 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_029 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_031 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_032 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_035 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_036 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_037 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_040 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_041 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_042 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_044 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_047 112.00 1 Transitional-Cell Papilloma Scheduled Sacrifice
Urinary System Urinary bladder 10000 PPM NA NA 2_048 112.00 1 Transitional-Cell Carcinoma Scheduled Sacrifice