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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Boric acid
CASRN: ="10043-35-3"
Study Number: C56417
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Untreated Control 50 NA 3_019 113.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_049 113.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_018 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_036 113.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_041 113.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 50 NA 2_050 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 2500 PPM 50 NA 2_041 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 2500 PPM 50 NA 2_015 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 50 NA 2_049 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_034 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 5000 PPM 50 NA 1_050 112.00 1 Squamous Cell Carcinoma, Metastatic Natural Death
Alimentary System Liver 5000 PPM 50 NA 1_002 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_010 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_011 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_023 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_035 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Pancreas Islets 2500 PPM 11 NA 2_010 112.00 1 Islet-Cell Adenoma Natural Death
Alimentary System Pancreas 5000 PPM 50 NA 1_050 112.00 1 Squamous Cell Carcinoma, Metastatic Natural Death
Alimentary System Stomach Forestomach Untreated Control 50 NA 3_003 113.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Forestomach 2500 PPM 16 NA 2_022 112.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Forestomach 2500 PPM 16 NA 2_039 112.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Forestomach 5000 PPM 50 NA 1_050 112.00 1 Squamous Cell Carcinoma Natural Death
Alimentary System Stomach Omentum Nos 2500 PPM NA NA 2_042 112.00 1 Hemangiosarcoma Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_001 113.00 1 Lymphoma, Undifferentiated-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_002 113.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_022 113.00 1 Lymphoma, Undifferentiated-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_049 113.00 1 Lymphoma, Undifferentiated-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_006 113.00 1 Lymphoma, Undifferentiated-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_015 113.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_032 113.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_038 113.00 1 Lymphoma, Undifferentiated-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_021 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_043 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_046 113.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_004 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_017 112.00 1 Lymphoma, Undifferentiated-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_018 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_023 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_001 112.00 1 Hemangiosarcoma, Uncertain Primary Or Metastatic Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_006 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_012 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_031 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_043 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_046 112.00 1 Hemangiosarcoma Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_047 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_033 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_047 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_007 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_024 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_001 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_003 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_017 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_018 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_035 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_041 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Untreated Control NA NA 3_028 113.00 1 Fibrosarcoma Natural Death
All Others Unspecified Untreated Control NA NA 3_039 113.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified 2500 PPM NA NA 2_017 112.00 1 Sarcoma, Nos Natural Death
All Others Unspecified 2500 PPM NA NA 2_046 112.00 1 Fibrosarcoma Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 39 NA 3_048 113.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 39 NA 3_008 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 39 NA 3_014 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 10 NA 2_048 112.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 10 NA 2_028 112.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 10 NA 2_022 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 43 NA 1_003 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 43 NA 1_020 112.00 1 Adenoma, Nos Terminal Sacrifice
Genital System Uterus Endometrium Untreated Control 50 NA 3_021 113.00 1 Hemangioma Terminal Sacrifice
Genital System Uterus Myometrium 2500 PPM 31 NA 2_020 112.00 1 Leiomyoma Terminal Sacrifice
Genital System Uterus Parovarian 5000 PPM 45 NA 1_021 112.00 1 Hemangioma Natural Death
Genital System Uterus 2500 PPM 31 NA 2_023 112.00 1 Endometrial Stromal Sarcoma Natural Death
Genital System Uterus 5000 PPM 49 NA 1_032 112.00 1 Endometrial Stromal Sarcoma Moribund Sacrifice
Genital System Uterus 5000 PPM 49 NA 1_045 112.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Genital System Uterus 5000 PPM 49 NA 1_050 112.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus 5000 PPM 49 NA 1_014 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 5000 PPM 49 NA 1_019 112.00 1 Hemangiopericytoma, Nos Terminal Sacrifice
Genital System Uterus 5000 PPM 49 NA 1_027 112.00 1 Hemangioma Terminal Sacrifice
Hematopoietic System Lymph node Pancreatic Lymph Node 2500 PPM 22 NA 2_017 112.00 1 Sarcoma, Nos, Metastatic Natural Death
Hematopoietic System Spleen Untreated Control 49 NA 3_004 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen Untreated Control 49 NA 3_031 113.00 1 Hemangiosarcoma Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 50 NA 1_050 112.00 1 Squamous Cell Carcinoma, Metastatic Natural Death
Hematopoietic System Spleen 5000 PPM 50 NA 1_006 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
Hematopoietic System Thymus Untreated Control 38 NA 3_035 113.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
Integumentary System Mammary gland Untreated Control 10 NA 3_033 113.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Integumentary System Mammary gland 2500 PPM 2 NA 2_043 112.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Integumentary System Mammary gland 5000 PPM 19 NA 1_006 112.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Integumentary System Skin 5000 PPM 48 NA 1_048 112.00 1 Squamous Cell Carcinoma Moribund Sacrifice
Musculoskeletal System Bone Vertebral Column 2500 PPM NA NA 2_027 112.00 1 Osteosarcoma Natural Death
Musculoskeletal System Bone 5000 PPM NA NA 1_032 112.00 1 Osteoma Moribund Sacrifice
Respiratory System Lung Untreated Control 50 NA 3_033 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 50 NA 3_036 113.00 1 Hepatocellular Carcinoma, Metastatic Terminal Sacrifice
Respiratory System Lung 2500 PPM 50 NA 2_018 112.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung 2500 PPM 50 NA 2_027 112.00 1 Osteosarcoma, Metastatic Natural Death
Respiratory System Lung 2500 PPM 50 NA 2_041 112.00 1 Hepatocellular Carcinoma, Metastatic Natural Death
Respiratory System Lung 2500 PPM 50 NA 2_014 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 50 NA 2_020 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 50 NA 2_021 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 50 NA 2_036 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_045 112.00 1 Alveolar/Bronchiolar Adenoma Moribund Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_002 112.00 1 Hepatocellular Carcinoma, Metastatic Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_010 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_011 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_017 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Special Senses System Eye 2500 PPM 1 NA 2_013 112.00 1 Carcinoma, Nos, Invasive Moribund Sacrifice
Special Senses System Harderian gland Hardarian Gland 2500 PPM NA NA 2_013 112.00 1 Carcinoma, Nos Moribund Sacrifice
Special Senses System Harderian gland Hardarian Gland 5000 PPM NA NA 1_008 112.00 1 Adenoma, Nos Terminal Sacrifice