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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Chlorpheniramine maleate
CASRN: ="113-92-8"
Study Number: C55265
Exposure Route: Gavage
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Vehicle Control 50 NA 3_012 112.00 1 Hepatocellular Adenoma Natural Death
Alimentary System Liver Vehicle Control 50 NA 3_034 112.00 1 Hepatocellular Adenoma Natural Death
Alimentary System Liver Vehicle Control 50 NA 3_008 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_017 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_037 112.00 1 Hemangiosarcoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_042 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_047 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 49 NA 2_014 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 100.0 MG/KG 49 NA 2_005 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 49 NA 2_040 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 200.0 MG/KG 50 NA 1_011 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 200.0 MG/KG 50 NA 1_032 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 200.0 MG/KG 50 NA 1_034 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 200.0 MG/KG 50 NA 1_043 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 200.0 MG/KG 50 NA 1_047 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Stomach Forestomach 100.0 MG/KG 48 NA 2_003 112.00 1 Squamous Cell Papilloma Terminal Sacrifice
All Others Unspecified Abdomen Vehicle Control NA NA 3_003 112.00 1 Sarcoma, Nos, Invasive Moribund Sacrifice
All Others Unspecified Back Vehicle Control NA NA 3_015 112.00 1 Fibrosarcoma Terminal Sacrifice
All Others Unspecified Leg Vehicle Control NA NA 3_003 112.00 1 Sarcoma, Nos Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_004 112.00 1 Leukemia, Granulocytic Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_006 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_022 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_026 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_034 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_038 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_049 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_005 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_007 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_008 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_016 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_018 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_024 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_025 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_028 112.00 1 Osteosarcoma, Metastatic Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_031 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_040 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_042 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_045 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_012 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_013 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_020 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_024 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_039 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_001 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_004 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_009 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_010 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_019 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_022 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_026 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_032 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_036 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_041 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_042 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 100.0 MG/KG NA NA 2_050 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 200.0 MG/KG NA NA 1_016 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 200.0 MG/KG NA NA 1_042 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 200.0 MG/KG NA NA 1_002 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 200.0 MG/KG NA NA 1_007 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 200.0 MG/KG NA NA 1_010 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 200.0 MG/KG NA NA 1_011 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 200.0 MG/KG NA NA 1_014 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 200.0 MG/KG NA NA 1_015 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Thorax 100.0 MG/KG NA NA 2_043 112.00 1 Myxosarcoma Moribund Sacrifice
Endocrine System Adrenal gland Capsule 100.0 MG/KG 49 NA 2_036 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Adrenal gland Medulla 200.0 MG/KG 50 NA 1_045 112.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Vehicle Control 50 NA 3_010 112.00 1 Cortical Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 46 NA 3_017 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 46 NA 3_024 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 46 NA 3_033 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 46 NA 3_043 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 46 NA 3_046 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_003 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_009 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_025 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_027 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_030 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_034 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_040 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_046 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 100.0 MG/KG 47 NA 2_048 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 200.0 MG/KG 45 NA 1_001 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 200.0 MG/KG 45 NA 1_013 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 200.0 MG/KG 45 NA 1_025 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 200.0 MG/KG 45 NA 1_032 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 200.0 MG/KG 45 NA 1_045 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Intermedia Vehicle Control 46 NA 3_035 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Intermedia Vehicle Control 46 NA 3_037 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Thyroid 100.0 MG/KG 49 NA 2_009 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 100.0 MG/KG 49 NA 2_016 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 100.0 MG/KG 49 NA 2_017 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 100.0 MG/KG 49 NA 2_030 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 200.0 MG/KG 47 NA 1_001 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 200.0 MG/KG 47 NA 1_045 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Genital System Ovary Vehicle Control 50 NA 3_020 112.00 1 Luteoma Terminal Sacrifice
Genital System Ovary 100.0 MG/KG 49 NA 2_023 112.00 1 Papillary Cystadenoma, Nos Terminal Sacrifice
Genital System Ovary 200.0 MG/KG 48 NA 1_021 112.00 1 Ganglioneuroma Natural Death
Genital System Uterus Vehicle Control 50 NA 3_026 112.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus Vehicle Control 50 NA 3_007 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus Vehicle Control 50 NA 3_033 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 100.0 MG/KG 49 NA 2_043 112.00 1 Leiomyoma Moribund Sacrifice
Genital System Uterus 100.0 MG/KG 49 NA 2_007 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 200.0 MG/KG 48 NA 1_038 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
Hematopoietic System Lymph node Lumbar Lymph Node 100.0 MG/KG 47 NA 2_048 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 50 NA 3_037 112.00 1 Hemangiosarcoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 19 NA 3_011 112.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Musculoskeletal System Bone Sacrum Vehicle Control NA NA 3_028 112.00 1 Osteosarcoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_003 112.00 1 Sarcoma, Nos, Metastatic Moribund Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_009 112.00 1 Alveolar/Bronchiolar Carcinoma Moribund Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_026 112.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung Vehicle Control 50 NA 3_002 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_014 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_017 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_023 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 49 NA 2_012 112.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 100.0 MG/KG 49 NA 2_010 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 49 NA 2_016 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 49 NA 2_028 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 49 NA 2_031 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 49 NA 2_032 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 200.0 MG/KG 50 NA 1_012 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 200.0 MG/KG 50 NA 1_025 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 200.0 MG/KG 50 NA 1_045 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 200.0 MG/KG 50 NA 1_049 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Vehicle Control NA NA 3_021 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Vehicle Control NA NA 3_028 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 100.0 MG/KG NA NA 2_019 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 100.0 MG/KG NA NA 2_033 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 100.0 MG/KG NA NA 2_046 112.00 1 Adenoma, Nos Terminal Sacrifice