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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Chlorpheniramine maleate
CASRN: ="113-92-8"
Study Number: C55265
Exposure Route: Gavage
TDMS Number:
Sex: Female
Strain and Species: F344 Rats

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Vehicle Control 50 NA 3_023 111.00 1 Neoplastic Nodule Moribund Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_031 111.00 1 Neoplastic Nodule Terminal Sacrifice
Alimentary System Liver 060.0 MG/KG 49 NA 1_033 111.00 1 Neoplastic Nodule Terminal Sacrifice
All Others Unspecified Abdomen Vehicle Control NA NA 3_029 111.00 1 Lipoma Terminal Sacrifice
All Others Unspecified Axilla Vehicle Control NA NA 3_043 111.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Eyelid Vehicle Control NA NA 3_036 111.00 1 Neurofibroma Terminal Sacrifice
All Others Unspecified Hip 030.0 MG/KG NA NA 2_043 111.00 1 Fibroma Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_002 111.00 1 Leukemia, Mononuclear Cell Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_016 111.00 1 Leukemia, Mononuclear Cell Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_019 111.00 1 Leukemia, Mononuclear Cell Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_045 111.00 1 Leukemia, Mononuclear Cell Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_042 111.00 1 Leukemia, Mononuclear Cell Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_003 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_006 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_029 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_031 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_034 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_041 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 030.0 MG/KG NA NA 2_013 111.00 1 Leukemia, Mononuclear Cell Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 030.0 MG/KG NA NA 2_018 111.00 1 Leukemia, Mononuclear Cell Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 030.0 MG/KG NA NA 2_012 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 030.0 MG/KG NA NA 2_031 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 1_002 111.00 1 Leukemia, Mononuclear Cell Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 060.0 MG/KG NA NA 1_020 111.00 1 Leukemia, Mononuclear Cell Terminal Sacrifice
All Others Unspecified Pelvis Nos Vehicle Control NA NA 3_037 111.00 1 Lipoma Natural Death
All Others Unspecified Tail 060.0 MG/KG NA NA 1_025 111.00 1 Fibroma Natural Death
Endocrine System Adrenal gland Medulla Vehicle Control 50 NA 3_016 111.00 1 Pheochromocytoma Moribund Sacrifice
Endocrine System Adrenal gland Medulla Vehicle Control 50 NA 3_017 111.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla Vehicle Control 50 NA 3_034 111.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla 030.0 MG/KG 49 NA 2_042 111.00 1 Pheochromocytoma Natural Death
Endocrine System Adrenal gland Medulla 030.0 MG/KG 49 NA 2_030 111.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Vehicle Control 50 NA 3_014 111.00 1 Cortical Adenoma Natural Death
Endocrine System Adrenal gland 030.0 MG/KG 49 NA 2_029 111.00 1 Cortical Adenoma Terminal Sacrifice
Endocrine System Adrenal gland 060.0 MG/KG 47 NA 1_035 111.00 1 Cortical Adenoma Terminal Sacrifice
Endocrine System Parathyroid gland 030.0 MG/KG 34 NA 2_002 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_018 111.00 1 Adenoma, Nos Dosing Accident
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_002 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_016 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_023 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_027 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_030 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_045 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_050 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_024 111.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_035 111.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_042 111.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_049 111.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_001 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_003 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_011 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_015 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_022 111.00 1 Carcinoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_025 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_028 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_031 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_038 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_039 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_040 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_046 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_047 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_018 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_050 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_007 111.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_032 111.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_042 111.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_005 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_009 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_017 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_027 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_030 111.00 1 Carcinoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_033 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_035 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_038 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 030.0 MG/KG 48 NA 2_048 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 060.0 MG/KG 45 NA 1_002 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 060.0 MG/KG 45 NA 1_019 111.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 060.0 MG/KG 45 NA 1_018 111.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary 060.0 MG/KG 45 NA 1_020 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 060.0 MG/KG 45 NA 1_033 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 060.0 MG/KG 45 NA 1_035 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 47 NA 3_016 111.00 1 C-Cell Adenoma Moribund Sacrifice
Endocrine System Thyroid Vehicle Control 47 NA 3_005 111.00 1 C-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 47 NA 3_029 111.00 1 C-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 47 NA 3_041 111.00 1 C-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 030.0 MG/KG 46 NA 2_013 111.00 1 C-Cell Adenoma Moribund Sacrifice
Endocrine System Thyroid 030.0 MG/KG 46 NA 2_029 111.00 1 C-Cell Adenoma Terminal Sacrifice
Genital System Clitoral gland Vehicle Control NA NA 3_023 111.00 1 Adenoma, Nos Moribund Sacrifice
Genital System Clitoral gland Vehicle Control NA NA 3_045 111.00 1 Adenoma, Nos Moribund Sacrifice
Genital System Clitoral gland Vehicle Control NA NA 3_008 111.00 1 Adenoma, Nos Terminal Sacrifice
Genital System Clitoral gland Vehicle Control NA NA 3_017 111.00 1 Adenoma, Nos Terminal Sacrifice
Genital System Clitoral gland Vehicle Control NA NA 3_047 111.00 1 Adenoma, Nos Terminal Sacrifice
Genital System Uterus Cervix Uteri Vehicle Control 49 NA 3_050 111.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_002 111.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_014 111.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus Vehicle Control 49 NA 3_035 111.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus Vehicle Control 49 NA 3_049 111.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus Vehicle Control 49 NA 3_005 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_011 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_032 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_034 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_040 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_046 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_019 111.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_024 111.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_004 111.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus 030.0 MG/KG 50 NA 2_042 111.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus 030.0 MG/KG 50 NA 2_014 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_015 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_027 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_029 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_031 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_045 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 030.0 MG/KG 50 NA 2_047 111.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 060.0 MG/KG 46 NA 1_012 111.00 1 Endometrial Stromal Polyp Natural Death
Integumentary System Mammary gland Vehicle Control 40 NA 3_009 111.00 1 Adenocarcinoma, Nos Moribund Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_010 111.00 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_030 111.00 1 Adenocarcinoma, Nos Moribund Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_030 111.00 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_012 111.00 1 Fibroadenoma Natural Death
Integumentary System Mammary gland Vehicle Control 40 NA 3_024 111.00 1 Fibroadenoma Natural Death
Integumentary System Mammary gland Vehicle Control 40 NA 3_001 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_006 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_008 111.00 1 Adenoma, Nos Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_008 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_021 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_025 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_031 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_032 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_038 111.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_038 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_040 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 40 NA 3_046 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland 030.0 MG/KG 33 NA 2_016 111.00 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary gland 030.0 MG/KG 33 NA 2_018 111.00 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary gland 030.0 MG/KG 33 NA 2_025 111.00 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary gland 030.0 MG/KG 33 NA 2_050 111.00 1 Adenocarcinoma, Nos Moribund Sacrifice
Integumentary System Mammary gland 030.0 MG/KG 33 NA 2_007 111.00 1 Fibroadenoma Natural Death
Integumentary System Mammary gland 030.0 MG/KG 33 NA 2_006 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary gland 030.0 MG/KG 33 NA 2_038 111.00 1 Fibroadenoma Terminal Sacrifice
Integumentary System Skin Back Vehicle Control 50 NA 3_039 111.00 1 Keratoacanthoma Terminal Sacrifice
Integumentary System Skin Lip Nos Vehicle Control 50 NA 3_008 111.00 1 Squamous Cell Papilloma Terminal Sacrifice
Integumentary System Zymbal gland Vehicle Control NA NA 3_030 111.00 1 Carcinoma, Nos Moribund Sacrifice
Nervous System Brain Cerebrum Vehicle Control 50 NA 3_022 111.00 1 Carcinoma, Nos, Invasive Terminal Sacrifice