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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Dimethyl morpholinophosphoramidate
CASRN: ="597-25-1"
Study Number: C54740
Exposure Route: Gavage
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Duodenum Vehicle Control 10 NA 3_023 112.00 1 Adenomatous Polyp, Nos Natural Death
Alimentary System Intestine Small Jejunum 600.0 MG/KG 42 NA 1_001 112.00 1 Leiomyosarcoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_004 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_008 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_017 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_028 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_029 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_033 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_036 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 47 NA 2_044 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 300.0 MG/KG 47 NA 2_001 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 47 NA 2_018 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 47 NA 2_045 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 600.0 MG/KG 49 NA 1_003 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 600.0 MG/KG 49 NA 1_026 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Stomach Forestomach 600.0 MG/KG 46 NA 1_050 112.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach 300.0 MG/KG 47 NA 2_009 112.00 1 Squamous Cell Carcinoma Terminal Sacrifice
All Others Unspecified Adipose Tissue Vehicle Control NA NA 3_004 112.00 1 Hemangioma Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_022 112.00 1 Lymphoma, Nos-Malignant Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_047 112.00 1 Lymphoma, Nos-Malignant Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_049 112.00 1 Lymphoma, Undifferentiated-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_007 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_009 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_026 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_035 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_041 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_042 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 2_017 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 2_008 112.00 1 Leukemia, Granulocytic Natural Death
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 2_010 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 2_024 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 2_049 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 2_002 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 2_023 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 2_040 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 600.0 MG/KG NA NA 1_011 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 600.0 MG/KG NA NA 1_035 112.00 1 Lymphoma, Nos-Malignant Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 600.0 MG/KG NA NA 1_049 112.00 1 Sarcoma, Nos, Metastatic Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 600.0 MG/KG NA NA 1_009 112.00 1 Leukemia, Granulocytic Natural Death
All Others Unspecified Multiple Organs Nos 600.0 MG/KG NA NA 1_039 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 600.0 MG/KG NA NA 1_042 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 600.0 MG/KG NA NA 1_044 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 600.0 MG/KG NA NA 1_046 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified 600.0 MG/KG NA NA 1_041 112.00 1 Sarcoma, Nos Natural Death
Endocrine System Adrenal gland 300.0 MG/KG 47 NA 2_022 112.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland 300.0 MG/KG 47 NA 2_026 112.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Pituitary gland Vehicle Control 49 NA 3_023 112.00 1 Chromophobe Adenoma Natural Death
Endocrine System Pituitary gland Vehicle Control 49 NA 3_039 112.00 1 Chromophobe Adenoma Natural Death
Endocrine System Pituitary gland Vehicle Control 49 NA 3_010 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Vehicle Control 49 NA 3_014 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Vehicle Control 49 NA 3_015 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Vehicle Control 49 NA 3_020 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Vehicle Control 49 NA 3_026 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Vehicle Control 49 NA 3_027 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Vehicle Control 49 NA 3_033 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Vehicle Control 49 NA 3_044 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 300.0 MG/KG 46 NA 2_014 112.00 1 Chromophobe Adenoma Natural Death
Endocrine System Pituitary gland 300.0 MG/KG 46 NA 2_012 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 300.0 MG/KG 46 NA 2_018 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 300.0 MG/KG 46 NA 2_026 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 300.0 MG/KG 46 NA 2_029 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 300.0 MG/KG 46 NA 2_033 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 300.0 MG/KG 46 NA 2_048 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 600.0 MG/KG 41 NA 1_002 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 600.0 MG/KG 41 NA 1_010 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 600.0 MG/KG 41 NA 1_017 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 600.0 MG/KG 41 NA 1_018 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 600.0 MG/KG 41 NA 1_027 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Pituitary gland 600.0 MG/KG 41 NA 1_037 112.00 1 Chromophobe Adenoma Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 45 NA 3_018 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 45 NA 3_027 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 45 NA 3_032 112.00 1 Papillary Cystadenoma, Nos Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 45 NA 3_046 112.00 1 Cystadenoma, Nos Terminal Sacrifice
Endocrine System Thyroid 600.0 MG/KG 45 NA 1_043 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Genital System Ovary Vehicle Control 49 NA 3_020 112.00 1 Hemangioma Terminal Sacrifice
Genital System Ovary Vehicle Control 49 NA 3_030 112.00 1 Papillary Cystadenoma, Nos Terminal Sacrifice
Genital System Uterus Vehicle Control 50 NA 3_007 112.00 1 Hemangioma Terminal Sacrifice
Genital System Uterus Vehicle Control 50 NA 3_035 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus Vehicle Control 50 NA 3_036 112.00 1 Leiomyosarcoma Terminal Sacrifice
Genital System Uterus 300.0 MG/KG 47 NA 2_006 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 300.0 MG/KG 47 NA 2_007 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 300.0 MG/KG 47 NA 2_012 112.00 1 Leiomyoma Terminal Sacrifice
Genital System Uterus 300.0 MG/KG 47 NA 2_013 112.00 1 Adenoma, Nos Terminal Sacrifice
Genital System Uterus 600.0 MG/KG 49 NA 1_011 112.00 1 Endometrial Stromal Sarcoma Moribund Sacrifice
Genital System Uterus 600.0 MG/KG 49 NA 1_027 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 600.0 MG/KG 49 NA 1_044 112.00 1 Hemangioma Terminal Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node 300.0 MG/KG 47 NA 2_028 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
Integumentary System Mammary gland Vehicle Control 49 NA 3_028 112.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Integumentary System Mammary gland 300.0 MG/KG 43 NA 2_021 112.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Integumentary System Mammary gland 600.0 MG/KG 46 NA 1_014 112.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Integumentary System Skin Lower Leg 300.0 MG/KG 47 NA 2_019 112.00 1 Keratoacanthoma Terminal Sacrifice
Musculoskeletal System Skeletal muscle Neck 600.0 MG/KG NA NA 1_049 112.00 1 Sarcoma, Nos Moribund Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_013 112.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung Vehicle Control 50 NA 3_023 112.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung Vehicle Control 50 NA 3_019 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_024 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 46 NA 2_035 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 46 NA 2_040 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 46 NA 2_046 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 600.0 MG/KG 50 NA 1_003 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 600.0 MG/KG 50 NA 1_005 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 600.0 MG/KG 50 NA 1_015 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 600.0 MG/KG 50 NA 1_036 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 600.0 MG/KG NA NA 1_015 112.00 1 Papillary Adenocarcinoma Terminal Sacrifice