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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Dimethyl morpholinophosphoramidate
CASRN: ="597-25-1"
Study Number: C54740
Exposure Route: Gavage
TDMS Number:
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Vehicle Control 50 NA 3_022 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_027 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_032 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver Vehicle Control 50 NA 3_009 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_013 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_014 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_014 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_015 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_019 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_020 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_030 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_040 112.00 1 Kupffer-Cell Sarcoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 NA 3_048 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_017 112.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_036 112.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_040 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_049 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_013 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 150.0 MG/KG 50 NA 2_041 112.00 1 Bile Duct Carcinoma Natural Death
Alimentary System Liver 150.0 MG/KG 50 NA 2_041 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 150.0 MG/KG 50 NA 2_050 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 150.0 MG/KG 50 NA 2_009 112.00 1 Hemangiosarcoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_012 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_021 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_032 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_035 112.00 1 Hemangiosarcoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_035 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_039 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_047 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 150.0 MG/KG 50 NA 2_047 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_010 112.00 1 Hemangiosarcoma, Metastatic Moribund Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_017 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_044 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_050 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_001 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 300.0 MG/KG 50 NA 1_008 112.00 1 Hepatocellular Adenoma Natural Death
Alimentary System Liver 300.0 MG/KG 50 NA 1_014 112.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 300.0 MG/KG 50 NA 1_011 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_011 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_013 112.00 1 Kupffer-Cell Sarcoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_015 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_016 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_027 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_028 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_029 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_033 112.00 1 Islet-Cell Carcinoma, Metastatic Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_036 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_040 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 300.0 MG/KG 50 NA 1_045 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Pancreas Islets 300.0 MG/KG 50 NA 1_033 112.00 1 Islet-Cell Carcinoma Terminal Sacrifice
Alimentary System Stomach Forestomach 150.0 MG/KG 50 NA 2_027 112.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Forestomach 150.0 MG/KG 50 NA 2_046 112.00 1 Squamous Cell Papilloma Terminal Sacrifice
All Others Unspecified Abdomen Vehicle Control NA NA 3_024 112.00 1 Sarcoma, Nos Moribund Sacrifice
All Others Unspecified Back Vehicle Control NA NA 3_017 112.00 1 Fibrosarcoma Terminal Sacrifice
All Others Unspecified Back Vehicle Control NA NA 3_019 112.00 1 Fibrosarcoma Terminal Sacrifice
All Others Unspecified Back 150.0 MG/KG NA NA 2_049 112.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Back 150.0 MG/KG NA NA 2_005 112.00 1 Neurofibrosarcoma Terminal Sacrifice
All Others Unspecified Back 150.0 MG/KG NA NA 2_032 112.00 1 Fibroma Terminal Sacrifice
All Others Unspecified Groin 300.0 MG/KG NA NA 1_018 112.00 1 Lipoma Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_003 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_050 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_004 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_036 112.00 1 Fibrosarcoma, Invasive Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 150.0 MG/KG NA NA 2_017 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 150.0 MG/KG NA NA 2_038 112.00 1 Myxosarcoma, Metastatic Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 150.0 MG/KG NA NA 2_007 112.00 1 Lymphoma, Undifferentiated-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 150.0 MG/KG NA NA 2_013 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 150.0 MG/KG NA NA 2_041 112.00 1 Bile Duct Carcinoma, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos 150.0 MG/KG NA NA 2_042 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 150.0 MG/KG NA NA 2_022 112.00 1 Sarcoma, Nos, Metastatic Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 1_008 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 300.0 MG/KG NA NA 1_018 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Thorax Vehicle Control NA NA 3_036 112.00 1 Fibrosarcoma Terminal Sacrifice
All Others Unspecified Thorax 150.0 MG/KG NA NA 2_038 112.00 1 Myxosarcoma Moribund Sacrifice
All Others Unspecified Thorax 300.0 MG/KG NA NA 1_017 112.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Thorax 300.0 MG/KG NA NA 1_045 112.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified Vehicle Control NA NA 3_001 112.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified 150.0 MG/KG NA NA 2_014 112.00 1 Sarcoma, Nos Moribund Sacrifice
All Others Unspecified 150.0 MG/KG NA NA 2_022 112.00 1 Sarcoma, Nos Terminal Sacrifice
Endocrine System Adrenal gland Capsule 150.0 MG/KG 50 NA 2_021 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Adrenal gland Capsule 150.0 MG/KG 50 NA 2_034 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Adrenal gland Medulla 150.0 MG/KG 50 NA 2_041 112.00 1 Pheochromocytoma Natural Death
Endocrine System Adrenal gland Medulla 300.0 MG/KG 50 NA 1_032 112.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Vehicle Control 50 NA 3_010 112.00 1 Cortical Adenoma Terminal Sacrifice
Endocrine System Adrenal gland Vehicle Control 50 NA 3_029 112.00 1 Cortical Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 48 NA 3_004 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 150.0 MG/KG 47 NA 2_033 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Thyroid 150.0 MG/KG 50 NA 2_024 112.00 1 Follicular-Cell Carcinoma Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 50 NA 3_021 112.00 1 Hemangioma Terminal Sacrifice
Hematopoietic System Spleen 150.0 MG/KG 49 NA 2_003 112.00 1 Hemangiosarcoma Natural Death
Hematopoietic System Spleen 300.0 MG/KG 50 NA 1_010 112.00 1 Hemangiosarcoma Moribund Sacrifice
Hematopoietic System Spleen 300.0 MG/KG 50 NA 1_017 112.00 1 Hemangiosarcoma Moribund Sacrifice
Hematopoietic System Thymus 150.0 MG/KG 40 NA 2_036 112.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
Integumentary System Skin Back 150.0 MG/KG 50 NA 2_050 112.00 1 Fibroma Natural Death
Integumentary System Skin Tail 150.0 MG/KG 50 NA 2_038 112.00 1 Squamous Cell Papilloma Moribund Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_003 112.00 1 Alveolar/Bronchiolar Adenoma Moribund Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_022 112.00 1 Hepatocellular Carcinoma, Metastatic Moribund Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_006 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_007 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_009 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_034 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_034 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 NA 3_049 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 150.0 MG/KG 50 NA 2_040 112.00 1 Alveolar/Bronchiolar Carcinoma Moribund Sacrifice
Respiratory System Lung 150.0 MG/KG 50 NA 2_007 112.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 150.0 MG/KG 50 NA 2_008 112.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 150.0 MG/KG 50 NA 2_013 112.00 1 Hepatocellular Carcinoma, Metastatic Natural Death
Respiratory System Lung 150.0 MG/KG 50 NA 2_004 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 150.0 MG/KG 50 NA 2_005 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 150.0 MG/KG 50 NA 2_012 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 150.0 MG/KG 50 NA 2_012 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 150.0 MG/KG 50 NA 2_020 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 150.0 MG/KG 50 NA 2_024 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_011 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_012 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_013 112.00 1 Kupffer-Cell Sarcoma,Metastatic Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_016 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_016 112.00 1 Hepatocellular Carcinoma, Metastatic Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_027 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_030 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_043 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 300.0 MG/KG 50 NA 1_047 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 300.0 MG/KG NA NA 1_025 112.00 1 Papillary Adenoma Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 300.0 MG/KG NA NA 1_036 112.00 1 Papillary Adenoma Terminal Sacrifice