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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Hydrochlorothiazide
CASRN: ="58-93-5"
Study Number: C55925
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Peyers Patch Untreated Control NA NA 3_025 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Alimentary System Intestine Small Peyers Patch Untreated Control NA NA 3_044 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_004 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_018 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_033 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_033 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 21 NA 2_030 112.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver 2500 PPM 21 NA 2_016 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 21 NA 2_018 112.00 1 Hemangiosarcoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 21 NA 2_021 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 21 NA 2_025 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 21 NA 2_035 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 21 NA 2_040 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_033 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Pancreas Islets Untreated Control 48 NA 3_047 112.00 1 Islet-Cell Adenoma Terminal Sacrifice
Alimentary System Pancreas 5000 PPM 50 NA 1_022 111.00 1 Sarcoma, Nos, Metastatic Natural Death
All Others Unspecified Face 2500 PPM NA NA 2_015 112.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Flank Untreated Control NA NA 3_008 112.00 1 Sarcoma, Nos Moribund Sacrifice
All Others Unspecified Flank Untreated Control NA NA 3_022 112.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified Flank Untreated Control NA NA 3_036 112.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified Flank 5000 PPM NA NA 1_022 111.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_032 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_043 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_045 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_046 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_049 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_050 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_007 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_009 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_024 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_026 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_027 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_028 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_033 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_035 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_040 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_047 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_008 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_024 112.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_034 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_045 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_012 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_039 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_043 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_003 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_013 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_019 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_021 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_022 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_025 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_029 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_032 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_036 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_037 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_042 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_049 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_006 111.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_018 111.00 1 Lymphoma, Undifferentiated-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_023 111.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_025 111.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_030 111.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_036 111.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_037 111.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_038 111.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_041 111.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_003 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_010 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_011 111.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_019 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_027 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_035 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_043 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_044 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Shoulder Untreated Control NA NA 3_010 112.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified Untreated Control NA NA 3_041 112.00 1 Osteosarcoma Terminal Sacrifice
Endocrine System Adrenal gland Capsule 2500 PPM 9 NA 2_012 112.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 49 NA 3_023 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 49 NA 3_026 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 49 NA 3_036 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 49 NA 3_039 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 49 NA 3_044 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 49 NA 2_003 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 49 NA 2_007 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 49 NA 2_011 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 49 NA 2_018 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 49 NA 2_025 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 49 NA 2_029 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 49 NA 2_040 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 49 NA 2_042 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 49 NA 1_001 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 49 NA 1_014 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Intermedia 2500 PPM 49 NA 2_022 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Intermedia 5000 PPM 49 NA 1_050 111.00 1 Carcinoma, Nos Terminal Sacrifice
Endocrine System Thyroid Untreated Control 49 NA 3_013 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Untreated Control 49 NA 3_026 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 2500 PPM 7 NA 2_012 112.00 1 Follicular-Cell Adenoma Natural Death
Endocrine System Thyroid 2500 PPM 7 NA 2_026 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 5000 PPM 50 NA 1_037 111.00 1 Follicular-Cell Adenoma Natural Death
Endocrine System Thyroid 5000 PPM 50 NA 1_003 111.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Genital System Ovary Untreated Control 48 NA 3_031 112.00 1 Hemangioma Natural Death
Genital System Uterus Endometrium Untreated Control 49 NA 3_010 112.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Genital System Uterus Untreated Control 49 NA 3_011 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
Genital System Uterus Untreated Control 49 NA 3_015 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus Untreated Control 49 NA 3_020 112.00 1 Hemangiosarcoma Terminal Sacrifice
Genital System Uterus 2500 PPM 45 NA 2_034 112.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Genital System Uterus 2500 PPM 45 NA 2_038 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 2500 PPM 45 NA 2_041 112.00 1 Hemangioma Terminal Sacrifice
Genital System Uterus 5000 PPM 50 NA 1_022 111.00 1 Sarcoma, Nos Natural Death
Genital System Uterus 5000 PPM 50 NA 1_004 111.00 1 Leiomyoma Terminal Sacrifice
Hematopoietic System Lymph node Thoracic Lymph Node 5000 PPM 50 NA 1_022 111.00 1 Sarcoma, Nos, Metastatic Natural Death
Hematopoietic System Lymph node 2500 PPM 24 NA 2_048 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen 2500 PPM 32 NA 2_018 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen 2500 PPM 32 NA 2_050 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 50 NA 1_020 111.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
Hematopoietic System Thymus 5000 PPM 39 NA 1_022 111.00 1 Sarcoma, Nos, Metastatic Natural Death
Integumentary System Mammary gland Untreated Control 48 NA 3_015 112.00 1 Mixed Tumor, Malignant Terminal Sacrifice
Integumentary System Mammary gland Untreated Control 48 NA 3_039 112.00 1 Acinar-Cell Carcinoma Terminal Sacrifice
Integumentary System Mammary gland 2500 PPM 9 NA 2_030 112.00 1 Mixed Tumor, Malignant Natural Death
Integumentary System Mammary gland 2500 PPM 9 NA 2_037 112.00 1 Mixed Tumor, Malignant Terminal Sacrifice
Integumentary System Mammary gland 2500 PPM 9 NA 2_040 112.00 1 Acinar-Cell Carcinoma Terminal Sacrifice
Integumentary System Mammary gland 5000 PPM 50 NA 1_024 111.00 1 Acinar-Cell Carcinoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_003 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_011 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_012 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_014 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_018 112.00 1 Hepatocellular Carcinoma, Metastatic Terminal Sacrifice
Respiratory System Lung 2500 PPM 15 NA 2_036 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 15 NA 2_048 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 15 NA 2_049 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_032 111.00 1 Alveolar/Bronchiolar Carcinoma Moribund Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_049 111.00 1 Alveolar/Bronchiolar Adenoma Moribund Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_032 112.00 1 Adenoma, Nos Moribund Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_009 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_014 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_035 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_040 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_042 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 2500 PPM NA NA 2_009 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 2500 PPM NA NA 2_026 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 2500 PPM NA NA 2_028 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 2500 PPM NA NA 2_032 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 2500 PPM NA NA 2_046 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 5000 PPM NA NA 1_049 111.00 1 Adenoma, Nos Moribund Sacrifice
Special Senses System Harderian gland Hardarian Gland 5000 PPM NA NA 1_003 111.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 5000 PPM NA NA 1_050 111.00 1 Adenoma, Nos Terminal Sacrifice