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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Hydrochlorothiazide
CASRN: ="58-93-5"
Study Number: C55925
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Duodenum Untreated Control 48 NA 3_012 113.00 1 Adenomatous Polyp, Nos Terminal Sacrifice
Alimentary System Intestine Small Duodenum Untreated Control 48 NA 3_046 113.00 1 Adenomatous Polyp, Nos Terminal Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_002 113.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_007 113.00 1 Hemangiosarcoma Terminal Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_009 113.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_012 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_013 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_021 113.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_025 113.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Untreated Control 48 NA 3_034 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_028 112.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_003 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_007 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_008 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_008 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_010 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_023 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_023 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_024 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_038 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_039 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 49 NA 2_046 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_015 111.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_029 111.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_029 111.00 1 Mixed Hepato/Cholangio Carcinoma Moribund Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_033 111.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_009 111.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 5000 PPM 50 NA 1_011 111.00 1 Hepatocellular Adenoma Natural Death
Alimentary System Liver 5000 PPM 50 NA 1_001 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_004 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_005 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_014 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_018 111.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_020 111.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_021 111.00 1 Hemangiosarcoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_021 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_023 111.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_028 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_030 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_030 111.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_034 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_036 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_036 111.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_041 111.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_045 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_046 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_050 111.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Stomach Forestomach Untreated Control 48 NA 3_005 113.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Forestomach 5000 PPM 50 NA 1_007 111.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Glandular Stomach Untreated Control 48 NA 3_032 113.00 1 Adenomatous Polyp, Nos Terminal Sacrifice
All Others Unspecified Abdomen Untreated Control NA NA 3_010 113.00 1 Fibrosarcoma Terminal Sacrifice
All Others Unspecified Abdominal Cavity 5000 PPM NA NA 1_014 111.00 1 Sarcoma, Nos, Metastatic Terminal Sacrifice
All Others Unspecified Back Untreated Control NA NA 3_004 113.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Back 2500 PPM NA NA 2_047 112.00 1 Sarcoma, Nos Natural Death
All Others Unspecified Back 2500 PPM NA NA 2_003 112.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified Back 2500 PPM NA NA 2_046 112.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified Back 5000 PPM NA NA 1_028 111.00 1 Fibroma Terminal Sacrifice
All Others Unspecified Flank 5000 PPM NA NA 1_014 111.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified Flank 5000 PPM NA NA 1_021 111.00 1 Fibrosarcoma Terminal Sacrifice
All Others Unspecified Mediastinum Nos Untreated Control NA NA 3_004 113.00 1 Sarcoma, Nos, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_038 113.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_008 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_016 113.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_017 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_018 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_032 113.00 1 Mast-Cell Tumor Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_039 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_005 112.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_008 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_024 111.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_029 111.00 1 Mixed Hepato/Cholangio Carcinoma, Metastatic Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_009 111.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_020 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_031 111.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_034 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_038 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_041 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_044 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_049 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Shoulder 2500 PPM NA NA 2_016 112.00 1 Fibrosarcoma Terminal Sacrifice
All Others Unspecified Trunk 5000 PPM NA NA 1_008 111.00 1 Fibroma Terminal Sacrifice
All Others Unspecified Upper Arm Untreated Control NA NA 3_036 113.00 1 Fibrosarcoma Terminal Sacrifice
Cardiovascular System Heart Untreated Control 49 NA 3_004 113.00 1 Sarcoma, Nos, Metastatic Natural Death
Endocrine System Adrenal gland Medulla Untreated Control 48 NA 3_024 113.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla Untreated Control 48 NA 3_025 113.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla Untreated Control 48 NA 3_044 113.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla 2500 PPM 49 NA 2_026 112.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla 5000 PPM 50 NA 1_021 111.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla 5000 PPM 50 NA 1_025 111.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_044 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 49 NA 1_026 111.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Thyroid Untreated Control 48 NA 3_016 113.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Untreated Control 48 NA 3_023 113.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Untreated Control 48 NA 3_046 113.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Genital System Seminal vesicle Untreated Control 48 NA 3_033 113.00 1 Sarcoma, Nos Terminal Sacrifice
Genital System Testis Untreated Control 48 NA 3_029 113.00 1 Interstitial-Cell Tumor Terminal Sacrifice
Hematopoietic System Bone marrow Untreated Control 48 NA 3_004 113.00 1 Sarcoma, Nos, Metastatic Natural Death
Hematopoietic System Lymph node Mesenteric Lymph Node 5000 PPM 49 NA 1_018 111.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen Untreated Control 48 NA 3_001 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen Untreated Control 48 NA 3_015 113.00 1 Hemangiosarcoma Terminal Sacrifice
Musculoskeletal System Bone Rib Untreated Control NA NA 3_004 113.00 1 Sarcoma, Nos, Metastatic Natural Death
Musculoskeletal System Skeletal muscle Upper Extremity Untreated Control NA NA 3_006 113.00 1 Sarcoma, Nos Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_002 113.00 1 Hepatocellular Carcinoma, Metastatic Moribund Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_004 113.00 1 Sarcoma, Nos, Metastatic Natural Death
Respiratory System Lung Untreated Control 49 NA 3_009 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_009 113.00 1 Hepatocellular Carcinoma, Metastatic Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_012 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_013 113.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_015 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_015 113.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_021 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_034 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_036 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_041 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 20 NA 2_044 112.00 1 Carcinoma, Nos, Metastatic Moribund Sacrifice
Respiratory System Lung 2500 PPM 20 NA 2_002 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 20 NA 2_011 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 20 NA 2_019 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 20 NA 2_029 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_033 111.00 1 Carcinoma, Nos, Metastatic Moribund Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_004 111.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_005 111.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_006 111.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_023 111.00 1 Hepatocellular Carcinoma, Metastatic Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_026 111.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_030 111.00 1 Hepatocellular Carcinoma, Metastatic Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_035 111.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_036 111.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_039 111.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_041 111.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_041 111.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 5000 PPM 50 NA 1_047 111.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Nasal cavity 5000 PPM NA NA 1_033 111.00 1 Carcinoma, Nos, Metastatic Moribund Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_035 113.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 2500 PPM NA NA 2_044 112.00 1 Carcinoma, Nos Moribund Sacrifice
Special Senses System Harderian gland Hardarian Gland 2500 PPM NA NA 2_009 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 5000 PPM NA NA 1_033 111.00 1 Carcinoma, Nos Moribund Sacrifice
Special Senses System Harderian gland Hardarian Gland 5000 PPM NA NA 1_045 111.00 1 Adenoma, Nos Terminal Sacrifice