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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Methyl carbamate
CASRN: ="598-55-0"
Study Number: C55594
Exposure Route: Gavage
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Colon Vehicle Control 45 NA 3_C12 112.00 1 Adenomatous Polyp, Nos Terminal Sacrifice
Alimentary System Liver Vehicle Control 49 NA 3_C06 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 49 NA 3_C08 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 49 NA 3_C12 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 49 NA 3_C17 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 49 NA 3_C17 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 001.0 G/KG 50 NA 1_C08 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 001.0 G/KG 50 NA 1_C11 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Alimentary System Liver 001.0 G/KG 50 NA 1_C16 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 001.0 G/KG 50 NA 1_C22 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 001.0 G/KG 50 NA 1_C30 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 001.0 G/KG 50 NA 1_C33 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 001.0 G/KG 50 NA 1_C49 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 500.0 MG/KG 50 NA 2_C01 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 500.0 MG/KG 50 NA 2_C08 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 500.0 MG/KG 50 NA 2_C09 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 500.0 MG/KG 50 NA 2_C12 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 500.0 MG/KG 50 NA 2_C23 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 500.0 MG/KG 50 NA 2_C40 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 500.0 MG/KG 50 NA 2_C49 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Pancreas Islets 001.0 G/KG 49 NA 1_C19 112.00 1 Islet-Cell Carcinoma Terminal Sacrifice
Alimentary System Stomach Forestomach 001.0 G/KG 47 NA 1_C17 112.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Forestomach 500.0 MG/KG 6 NA 2_C06 112.00 1 Squamous Cell Papilloma Terminal Sacrifice
All Others Unspecified Lower Leg Nos 500.0 MG/KG NA NA 2_C14 112.00 1 Sarcoma, Nos Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C21 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C30 112.00 1 Osteosarcoma, Metastatic Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C10 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C35 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C03 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C04 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C05 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C12 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C27 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C31 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C33 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C34 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C39 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C46 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 3_C48 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C07 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C14 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C24 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C35 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C45 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C02 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C09 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C15 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C26 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C38 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C41 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 001.0 G/KG NA NA 1_C47 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C07 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C20 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C25 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C29 112.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C43 112.00 1 Lymphoma, Mixed-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C46 112.00 1 Neurilemoma, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C06 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C12 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C24 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C30 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C41 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 500.0 MG/KG NA NA 2_C45 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Thoracic Cavity Nos Vehicle Control NA NA 3_C16 112.00 1 Osteosarcoma Terminal Sacrifice
All Others Unspecified Vehicle Control NA NA 3_C20 112.00 1 Hemangioma Terminal Sacrifice
All Others Unspecified 500.0 MG/KG NA NA 2_C46 112.00 1 Neurilemoma, Malignant Natural Death
Endocrine System Adrenal gland Medulla Vehicle Control 48 NA 3_C50 112.00 1 Pheochromocytoma, Malignant Terminal Sacrifice
Endocrine System Adrenal gland Vehicle Control 48 NA 3_C18 112.00 1 Cortical Adenoma Terminal Sacrifice
Endocrine System Adrenal gland Vehicle Control 48 NA 3_C42 112.00 1 Cortical Adenoma Terminal Sacrifice
Endocrine System Adrenal gland 500.0 MG/KG 6 NA 2_C49 112.00 1 Cortical Adenoma Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C15 112.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C03 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C04 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C11 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C17 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C25 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C29 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C44 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Vehicle Control 49 NA 3_C46 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 500.0 MG/KG 40 NA 2_C26 112.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 500.0 MG/KG 40 NA 2_C45 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 500.0 MG/KG 40 NA 2_C49 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Intermedia Vehicle Control 49 NA 3_C50 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 48 NA 3_C14 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Vehicle Control 48 NA 3_C16 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 001.0 G/KG 49 NA 1_C11 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid 001.0 G/KG 49 NA 1_C40 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Genital System Ovary Vehicle Control 49 NA 3_C34 112.00 1 Cystadenoma, Nos Terminal Sacrifice
Genital System Ovary 500.0 MG/KG 15 NA 2_C28 112.00 1 Teratoma, Nos Natural Death
Genital System Ovary 500.0 MG/KG 15 NA 2_C10 112.00 1 Cystadenoma, Nos Terminal Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_C06 112.00 1 Endometrial Stromal Sarcoma Terminal Sacrifice
Genital System Uterus Vehicle Control 49 NA 3_C29 112.00 1 Neurofibrosarcoma Terminal Sacrifice
Genital System Uterus 001.0 G/KG 50 NA 1_C40 112.00 1 Leiomyosarcoma Terminal Sacrifice
Genital System Uterus 500.0 MG/KG 29 NA 2_C09 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 500.0 MG/KG 29 NA 2_C14 112.00 1 Sarcoma, Nos, Invasive Terminal Sacrifice
Genital System Uterus 500.0 MG/KG 29 NA 2_C44 112.00 1 Hemangioma Terminal Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node 001.0 G/KG 49 NA 1_C20 112.00 1 Lymphoma, Nos-Malignant Natural Death
Hematopoietic System Lymph node Mesenteric Lymph Node 500.0 MG/KG 6 NA 2_C49 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen 001.0 G/KG 49 NA 1_C23 112.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
Integumentary System Mammary gland 500.0 MG/KG 4 NA 2_C17 112.00 1 Adenocarcinoma, Nos Natural Death
Musculoskeletal System Bone Vertebra Vehicle Control NA NA 3_C30 112.00 1 Osteosarcoma Moribund Sacrifice
Nervous System Brain 001.0 G/KG 50 NA 1_C27 112.00 1 Glioma, Nos Terminal Sacrifice
Respiratory System Lung Vehicle Control 49 NA 3_C04 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 49 NA 3_C06 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 49 NA 3_C16 112.00 1 Osteosarcoma, Metastatic Terminal Sacrifice
Respiratory System Lung Vehicle Control 49 NA 3_C18 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 49 NA 3_C22 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 49 NA 3_C25 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 49 NA 3_C28 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 49 NA 3_C39 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 001.0 G/KG 50 NA 1_C24 112.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung 001.0 G/KG 50 NA 1_C06 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 001.0 G/KG 50 NA 1_C09 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 001.0 G/KG 50 NA 1_C27 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 500.0 MG/KG 50 NA 2_C13 112.00 1 Lymphoma, Nos-Malignant Natural Death
Respiratory System Lung 500.0 MG/KG 50 NA 2_C17 112.00 1 Adenocarcinoma, Nos, Metastatic Natural Death
Respiratory System Lung 500.0 MG/KG 50 NA 2_C14 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 500.0 MG/KG 50 NA 2_C14 112.00 1 Sarcoma, Nos, Metastatic Terminal Sacrifice
Respiratory System Lung 500.0 MG/KG 50 NA 2_C15 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 500.0 MG/KG 50 NA 2_C23 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 500.0 MG/KG 50 NA 2_C49 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 500.0 MG/KG 50 NA 2_C50 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Special Senses System Eye 001.0 G/KG 28 NA 1_C10 112.00 1 Melanoma, Malignant Dosing Accident
Special Senses System Harderian gland Hardarian Gland Vehicle Control NA NA 3_C49 112.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 500.0 MG/KG NA NA 2_C42 112.00 1 Adenoma, Nos Terminal Sacrifice
Urinary System Kidney Vehicle Control 49 NA 3_C16 112.00 1 Osteosarcoma, Metastatic Terminal Sacrifice