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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Pentachloronitrobenzene
CASRN: ="82-68-8"
Study Number: C00419B
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Untreated Control 50 NA 3_004 113.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_040 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 50 NA 3_047 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 50 NA 2_025 113.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver 2500 PPM 50 NA 2_029 113.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver 2500 PPM 50 NA 2_036 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 2500 PPM 50 NA 2_038 113.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 4640 PPM 20 NA 6_010 98.00 1 Hepatocellular Carcinoma Natural Death
Alimentary System Liver 4640 PPM 20 NA 6_001 98.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 4640 PPM 20 NA 6_023 98.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_012 113.00 1 Hepatocellular Adenoma Natural Death
Alimentary System Liver 5000 PPM 50 NA 1_014 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_035 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 5000 PPM 50 NA 1_045 113.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Stomach Forestomach Untreated Control 50 NA 3_021 113.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Forestomach 2500 PPM 50 NA 2_001 113.00 1 Squamous Cell Papilloma Terminal Sacrifice
Alimentary System Stomach Forestomach 2500 PPM 50 NA 2_002 113.00 1 Squamous Cell Papilloma Terminal Sacrifice
All Others Unspecified Axilla Untreated Control NA NA 3_006 113.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Back 4640 PPM NA NA 6_009 98.00 1 Fibrosarcoma Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_010 113.00 1 Mesothelioma, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_034 113.00 1 Leukemia, Lymphocytic Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_042 113.00 1 Adenocarcinoma, Nos, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 4_004 97.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_007 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_017 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_032 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_046 113.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_047 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2320 PPM NA NA 5_049 98.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_010 113.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_030 113.00 1 Lymphoma, Undifferentiated-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_020 113.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_036 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_037 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 2500 PPM NA NA 2_039 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 4640 PPM NA NA 6_016 98.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 4640 PPM NA NA 6_019 98.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 4640 PPM NA NA 6_005 98.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 4640 PPM NA NA 6_023 98.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 4640 PPM NA NA 6_042 98.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_004 113.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_022 113.00 1 Lymphoma, Undifferentiated-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_008 113.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_036 113.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_049 113.00 1 Lymphoma, Undifferentiated-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 5000 PPM NA NA 1_045 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Cardiovascular System Heart 2500 PPM 49 NA 2_044 113.00 1 Hemangiosarcoma Natural Death
Endocrine System Adrenal gland Medulla 5000 PPM 49 NA 1_004 113.00 1 Pheochromocytoma Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_023 113.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_001 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_015 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_024 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_027 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_030 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_032 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_037 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 36 NA 3_043 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 43 NA 2_030 113.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 43 NA 2_045 113.00 1 Adenoma, Nos Natural Death
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 43 NA 2_006 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 43 NA 2_014 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 43 NA 2_037 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 43 NA 2_039 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 2500 PPM 43 NA 2_042 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 36 NA 1_010 113.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 36 NA 1_014 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 36 NA 1_018 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 36 NA 1_020 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 36 NA 1_037 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 5000 PPM 36 NA 1_045 113.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Thyroid 5000 PPM 48 NA 1_004 113.00 1 Follicular-Cell Adenoma Moribund Sacrifice
Genital System Ovary Untreated Control 49 NA 3_015 113.00 1 Papillary Adenoma Terminal Sacrifice
Genital System Ovary 2500 PPM 50 NA 2_026 113.00 1 Teratoma, Nos Natural Death
Genital System Ovary 2500 PPM 50 NA 2_002 113.00 1 Granulosa-Cell Tumor Terminal Sacrifice
Genital System Ovary 2500 PPM 50 NA 2_014 113.00 1 Cystadenoma, Nos Terminal Sacrifice
Genital System Ovary 5000 PPM 50 NA 1_017 113.00 1 Cystadenoma, Nos Terminal Sacrifice
Genital System Ovary 5000 PPM 50 NA 1_032 113.00 1 Teratoma, Nos Terminal Sacrifice
Genital System Uterus Untreated Control 50 NA 3_042 113.00 1 Adenocarcinoma, Nos Natural Death
Genital System Uterus 2500 PPM 49 NA 2_034 113.00 1 Endometrial Stromal Polyp Accidently Killed
Genital System Uterus 2500 PPM 49 NA 2_014 113.00 1 Leiomyoma Terminal Sacrifice
Genital System Uterus 5000 PPM 49 NA 1_004 113.00 1 Hemangioma Moribund Sacrifice
Genital System Uterus 5000 PPM 49 NA 1_028 113.00 1 Endometrial Stromal Polyp Natural Death
Hematopoietic System Lymph node Mesenteric Lymph Node 2500 PPM 47 NA 2_008 113.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node 4640 PPM 13 NA 6_009 98.00 1 Fibrosarcoma, Metastatic Natural Death
Hematopoietic System Spleen Vehicle Control 20 NA 4_001 97.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Spleen Untreated Control 50 NA 3_002 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen Untreated Control 50 NA 3_019 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen 2320 PPM 23 NA 5_037 98.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Spleen 4640 PPM 20 NA 6_004 98.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Spleen 5000 PPM 50 NA 1_007 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
Hematopoietic System Thymus Untreated Control 25 NA 3_015 113.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
Integumentary System Mammary gland 2320 PPM 23 NA 5_019 98.00 1 Adenoma, Nos Natural Death
Integumentary System Mammary gland 2320 PPM 23 NA 5_021 98.00 1 Adenocarcinoma, Nos Scheduled Sacrifice
Integumentary System Mammary gland 2320 PPM 23 NA 5_025 98.00 1 Adenoma, Nos Scheduled Sacrifice
Integumentary System Mammary gland 2500 PPM 25 NA 2_015 113.00 1 Adenocarcinoma, Nos Natural Death
Integumentary System Mammary gland 5000 PPM 13 NA 1_015 113.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Musculoskeletal System Bone Pelvic Bones 2500 PPM NA NA 2_040 113.00 1 Osteosarcoma Moribund Sacrifice
Respiratory System Lung Untreated Control 50 NA 3_012 113.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung Untreated Control 50 NA 3_015 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 50 NA 3_035 113.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 50 NA 2_012 113.00 1 Alveolar/Bronchiolar Adenoma Moribund Sacrifice
Respiratory System Lung 2500 PPM 50 NA 2_040 113.00 1 Osteosarcoma, Metastatic Moribund Sacrifice
Respiratory System Lung 2500 PPM 50 NA 2_044 113.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 2500 PPM 50 NA 2_044 113.00 1 Hemangiosarcoma, Metastatic Natural Death
Respiratory System Lung 2500 PPM 50 NA 2_046 113.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 2500 PPM 50 NA 2_005 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 2500 PPM 50 NA 2_038 113.00 1 Hepatocellular Carcinoma, Metastatic Terminal Sacrifice
Respiratory System Lung 4640 PPM 20 NA 6_010 98.00 1 Osteosarcoma, Metastatic Natural Death
Respiratory System Lung 4640 PPM 20 NA 6_038 98.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 5000 PPM 49 NA 1_027 113.00 1 Adenocarcinoma, Nos, Metastatic Moribund Sacrifice
Respiratory System Lung 5000 PPM 49 NA 1_033 113.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 5000 PPM 49 NA 1_041 113.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 5000 PPM 49 NA 1_049 113.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 5000 PPM 49 NA 1_017 113.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_005 113.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_017 113.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_035 113.00 1 Adenoma, Nos Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland 5000 PPM NA NA 1_027 113.00 1 Adenocarcinoma, Nos Moribund Sacrifice
Urinary System Kidney Untreated Control 50 NA 3_009 113.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
Urinary System Urinary bladder Untreated Control NA NA 3_022 113.00 1 Hemangioma Moribund Sacrifice