If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Tetracycline hydrochloride
CASRN: ="64-75-5"
Study Number: C55561
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Ileum Untreated Control 46 NA 3_109 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_120 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_122 112.00 1 Hepatocellular Adenoma Moribund Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_122 112.00 1 Hepatocellular Carcinoma Moribund Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_114 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_116 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_117 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_118 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_119 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_133 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_140 112.00 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver Untreated Control 49 NA 3_141 112.00 1 Hepatocellular Carcinoma Terminal Sacrifice
Alimentary System Liver 12500 PPM 48 NA 2_027 112.00 1 Hemangiosarcoma Terminal Sacrifice
Alimentary System Pancreas Islets 25000 PPM 49 NA 1_086 112.00 1 Islet-Cell Adenoma Terminal Sacrifice
Alimentary System Tongue Untreated Control NA NA 3_145 112.00 1 Papilloma, Nos Moribund Sacrifice
All Others Unspecified Back 12500 PPM NA NA 2_008 112.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Lumbar Region 25000 PPM NA NA 1_084 112.00 1 Hemangiosarcoma Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_138 112.00 1 Osteosarcoma, Metastatic Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_145 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_113 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_105 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_106 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_107 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_108 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_110 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_123 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_131 112.00 1 Alveolar/Bronchiolar Carcinoma, Metastatic Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_147 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_149 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_008 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_045 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_049 112.00 1 Lymphoma, Undifferentiated-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_024 112.00 1 Osteosarcoma Natural Death
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_046 112.00 1 Osteosarcoma, Metastatic Natural Death
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_007 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_010 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_030 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_038 112.00 1 Lymphoma, Histiocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 12500 PPM NA NA 2_039 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_057 112.00 1 Lymphoma, Nos-Malignant Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_074 112.00 1 Lymphoma, Mixed-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_081 112.00 1 Lymphoma, Undifferentiated-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_073 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_075 112.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_065 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_068 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_077 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_080 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_083 112.00 1 Lymphoma, Lymphocytic-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_090 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_093 112.00 1 Lymphoma, Undifferentiated-Malignant Type Terminal Sacrifice
All Others Unspecified Multiple Organs Nos 25000 PPM NA NA 1_096 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
All Others Unspecified Neck Nos 25000 PPM NA NA 1_076 112.00 1 Hemangiosarcoma Natural Death
All Others Unspecified Untreated Control NA NA 3_139 112.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Untreated Control NA NA 3_111 112.00 1 Fibrosarcoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla Untreated Control 49 NA 3_150 112.00 1 Pheochromocytoma Terminal Sacrifice
Endocrine System Adrenal gland Medulla 25000 PPM 50 NA 1_073 112.00 1 Pheochromocytoma Natural Death
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_120 112.00 1 Carcinoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_145 112.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_102 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_104 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_106 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_108 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_118 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_119 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_133 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_140 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_141 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary Untreated Control 48 NA 3_142 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 12500 PPM 46 NA 2_005 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 12500 PPM 46 NA 2_015 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 25000 PPM 49 NA 1_074 112.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 25000 PPM 49 NA 1_081 112.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 25000 PPM 49 NA 1_051 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 25000 PPM 49 NA 1_077 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Pituitary gland Anterior Pituitary 25000 PPM 49 NA 1_079 112.00 1 Adenoma, Nos Terminal Sacrifice
Endocrine System Thyroid Untreated Control 49 NA 3_145 112.00 1 Follicular-Cell Adenoma Moribund Sacrifice
Endocrine System Thyroid Untreated Control 49 NA 3_124 112.00 1 Follicular-Cell Adenoma Natural Death
Endocrine System Thyroid Untreated Control 49 NA 3_131 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Endocrine System Thyroid Untreated Control 49 NA 3_133 112.00 1 Follicular-Cell Adenoma Terminal Sacrifice
Genital System Ovary Untreated Control 48 NA 3_104 112.00 1 Granulosa-Cell Tumor Terminal Sacrifice
Genital System Ovary 12500 PPM 16 NA 2_028 112.00 1 Choriocarcinoma Natural Death
Genital System Ovary 12500 PPM 16 NA 2_039 112.00 1 Granulosa-Cell Tumor Terminal Sacrifice
Genital System Ovary 12500 PPM 16 NA 2_044 112.00 1 Papillary Adenoma Terminal Sacrifice
Genital System Ovary 25000 PPM 50 NA 1_084 112.00 1 Teratoma, Benign Moribund Sacrifice
Genital System Uterus Cervix Uteri 25000 PPM 50 NA 1_062 112.00 1 Leiomyosarcoma Moribund Sacrifice
Genital System Uterus 12500 PPM 44 NA 2_011 112.00 1 Endometrial Stromal Polyp Terminal Sacrifice
Genital System Uterus 12500 PPM 44 NA 2_034 112.00 1 Leiomyosarcoma Terminal Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node Untreated Control 48 NA 3_142 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Lymph node Untreated Control 48 NA 3_146 112.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
Hematopoietic System Spleen Untreated Control 49 NA 3_102 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
Hematopoietic System Spleen Untreated Control 49 NA 3_121 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen Untreated Control 49 NA 3_144 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen 12500 PPM 45 NA 2_020 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
Hematopoietic System Spleen 12500 PPM 45 NA 2_044 112.00 1 Lymphoma, Mixed-Malignant Type Terminal Sacrifice
Hematopoietic System Spleen 25000 PPM 49 NA 1_076 112.00 1 Hemangiosarcoma Natural Death
Hematopoietic System Spleen 25000 PPM 49 NA 1_087 112.00 1 Lymphoma, Nos-Malignant Terminal Sacrifice
Integumentary System Mammary gland Untreated Control 49 NA 3_135 112.00 1 Adenocarcinoma, Nos Terminal Sacrifice
Integumentary System Skin Face 25000 PPM 50 NA 1_070 112.00 1 Papilloma, Nos Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_122 112.00 1 Alveolar/Bronchiolar Carcinoma Moribund Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_125 112.00 1 Alveolar/Bronchiolar Adenoma Moribund Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_114 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Untreated Control 49 NA 3_131 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 12500 PPM 48 NA 2_009 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 25000 PPM 50 NA 1_092 112.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung 25000 PPM 50 NA 1_053 112.00 1 Alveolar/Bronchiolar Carcinoma Terminal Sacrifice
Respiratory System Lung 25000 PPM 50 NA 1_059 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 25000 PPM 50 NA 1_078 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 25000 PPM 50 NA 1_093 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 25000 PPM 50 NA 1_096 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 25000 PPM 50 NA 1_097 112.00 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 3_114 112.00 1 Adenoma, Nos Terminal Sacrifice