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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Trisodium ethylenediaminetetraacetate trihydrate (EDTA)
CASRN: ="150-38-9"
Study Number: C03974
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Female
Strain and Species: F344 Rats

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Ileum 3750 PPM 32 NA 1_082 110.00 1 Leiomyoma Scheduled Sacrifice
Alimentary System Liver 3750 PPM 49 NA 1_094 110.00 1 Neoplastic Nodule Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_232 110.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 3750 PPM NA NA 1_081 110.00 1 Leukemia, Lymphocytic Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 3750 PPM NA NA 1_098 110.00 1 Leukemia, Nos Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 3750 PPM NA NA 1_078 110.00 1 Leukemia, Lymphocytic Natural Death
All Others Unspecified Multiple Organs Nos 3750 PPM NA NA 1_085 110.00 1 Leukemia, Nos Natural Death
All Others Unspecified Multiple Organs Nos 3750 PPM NA NA 1_054 110.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 3750 PPM NA NA 1_064 110.00 1 Leukemia, Nos Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 3750 PPM NA NA 1_086 110.00 1 Leukemia, Nos Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 3750 PPM NA NA 1_088 110.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
All Others Unspecified Untreated Control NA NA 3_239 110.00 1 Squamous Cell Carcinoma Scheduled Sacrifice
All Others Unspecified 3750 PPM NA NA 1_090 110.00 1 Squamous Cell Carcinoma Moribund Sacrifice
All Others Unspecified 3750 PPM NA NA 1_065 110.00 1 Fibroadenoma Scheduled Sacrifice
All Others Unspecified 7500 PPM NA NA 2_152 110.00 1 Fibroadenoma Scheduled Sacrifice
All Others Unspecified 7500 PPM NA NA 2_182 110.00 1 Fibroadenoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 20 NA 3_238 110.00 1 Pheochromocytoma Natural Death
Endocrine System Adrenal gland 3750 PPM 49 NA 1_089 110.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 7500 PPM 48 NA 2_170 110.00 1 Pheochromocytoma Moribund Sacrifice
Endocrine System Adrenal gland 7500 PPM 48 NA 2_185 110.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Adrenal gland 7500 PPM 48 NA 2_192 110.00 1 Pheochromocytoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 19 NA 3_230 110.00 1 Chromophobe Adenoma Moribund Sacrifice
Endocrine System Pituitary gland Untreated Control 19 NA 3_227 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 19 NA 3_231 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 19 NA 3_234 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 19 NA 3_237 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 19 NA 3_239 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_054 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_069 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_070 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_074 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_077 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_079 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_080 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_083 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_097 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 3750 PPM 48 NA 1_100 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_170 110.00 1 Chromophobe Adenoma Moribund Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_152 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_155 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_159 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_176 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_177 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_178 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_180 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_182 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_190 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Pituitary gland 7500 PPM 50 NA 2_194 110.00 1 Chromophobe Adenoma Scheduled Sacrifice
Endocrine System Thyroid Positive Control 4 NA 4_070 38.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 4 NA 4_078 38.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 4 NA 4_080 38.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 4 NA 4_088 38.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 9 NA 5_154 42.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 9 NA 5_158 42.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 9 NA 5_172 42.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 9 NA 5_176 42.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 9 NA 5_178 42.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 9 NA 5_184 42.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 9 NA 5_186 42.00 1 Adenoma, Nos
Endocrine System Thyroid Positive Control 9 NA 5_200 42.00 1 Adenoma, Nos
Endocrine System Thyroid 7500 PPM 37 NA 2_159 110.00 1 Follicular-Cell Carcinoma Scheduled Sacrifice
Endocrine System Thyroid 7500 PPM 37 NA 2_166 110.00 1 C-Cell Adenoma Scheduled Sacrifice
Genital System Ovary 7500 PPM 47 NA 2_182 110.00 1 Cystadenoma, Nos Scheduled Sacrifice
Genital System Uterus Untreated Control 20 NA 3_221 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus Untreated Control 20 NA 3_233 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus Untreated Control 20 NA 3_235 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus Untreated Control 20 NA 3_237 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus Untreated Control 20 NA 3_240 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 3750 PPM 50 NA 1_078 110.00 1 Endometrial Stromal Polyp Natural Death
Genital System Uterus 3750 PPM 50 NA 1_074 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 3750 PPM 50 NA 1_080 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 3750 PPM 50 NA 1_086 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 3750 PPM 50 NA 1_087 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 3750 PPM 50 NA 1_095 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_171 110.00 1 Endometrial Stromal Polyp Moribund Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_152 110.00 1 Leiomyosarcoma Scheduled Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_154 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_157 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_164 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_173 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_174 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_185 110.00 1 Adenocarcinoma, Nos Scheduled Sacrifice
Genital System Uterus 7500 PPM 50 NA 2_186 110.00 1 Endometrial Stromal Polyp Scheduled Sacrifice
Hematopoietic System Lymph node 3750 PPM 46 NA 1_085 110.00 1 Lymphoma, Nos-Malignant Natural Death
Integumentary System Mammary gland Untreated Control 14 NA 3_223 110.00 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary gland Untreated Control 14 NA 3_226 110.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 14 NA 3_227 110.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 14 NA 3_237 110.00 1 Intraductal Papilloma Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 14 NA 3_239 110.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 3750 PPM 39 NA 1_090 110.00 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary gland 3750 PPM 39 NA 1_079 110.00 1 Adenoma, Nos Scheduled Sacrifice
Integumentary System Mammary gland 3750 PPM 39 NA 1_087 110.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 3750 PPM 39 NA 1_099 110.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 7500 PPM 33 NA 2_197 110.00 1 Fibroadenoma Natural Death
Integumentary System Mammary gland 7500 PPM 33 NA 2_182 110.00 1 Intraductal Carcinoma Scheduled Sacrifice
Integumentary System Mammary gland 7500 PPM 33 NA 2_184 110.00 1 Fibroadenoma Scheduled Sacrifice
Integumentary System Mammary gland 7500 PPM 33 NA 2_195 110.00 1 Fibroadenoma Scheduled Sacrifice
Nervous System Brain Cerebrum Untreated Control 19 NA 3_239 110.00 1 Glioma, Nos Scheduled Sacrifice
Respiratory System Larynx 3750 PPM 1 NA 1_068 110.00 1 Squamous Cell Papilloma Moribund Sacrifice
Respiratory System Lung 3750 PPM 48 NA 1_073 110.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 3750 PPM 48 NA 1_093 110.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 3750 PPM 48 NA 1_099 110.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 7500 PPM 48 NA 2_188 110.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 7500 PPM 48 NA 2_200 110.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Special Senses System Ear Lobule 7500 PPM 50 NA 2_191 110.00 1 Neurofibroma Scheduled Sacrifice