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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 1,1,2,2-Tetrachloroethane
CASRN: ="79-34-5"
Study Number: C03554E
Exposure Route: DOSED FEED
TDMS Number: 0355411
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Ileum Vehicle Control 10 18 87 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Bile Duct 150 MG/KG 10 25 121 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 150 MG/KG 10 26 126 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 150 MG/KG 10 26 127 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 150 MG/KG 10 26 128 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 150 MG/KG 10 26 130 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 27 131 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 27 132 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 27 133 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 27 134 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 27 135 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 28 136 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 28 137 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 28 138 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 28 139 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 300 MG/KG 10 28 140 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 23 112 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 23 113 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 24 116 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 24 118 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 124 92 1 Hypertrophy Mild Accidentally Killed
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 121 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 122 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 123 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 125 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 126 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 127 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 128 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 129 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 130 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 131 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 132 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 133 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 134 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 135 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 136 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 137 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 138 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 139 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 140 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 121 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 122 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 123 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 131 92 1 Mitotic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 132 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 133 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 134 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 135 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 136 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 137 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 138 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 139 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 140 92 1 Mitotic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 139 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 23 112 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 124 92 1 Necrosis Minimal Accidentally Killed
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 121 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 122 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 123 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 125 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 129 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 130 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 131 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 132 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 133 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 134 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 27 135 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 136 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 137 92 1 Necrosis Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 138 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 139 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 300 MG/KG 10 28 140 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 21 101 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 21 102 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 21 103 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 21 104 92 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 21 105 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 22 106 92 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 22 107 92 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 22 108 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 22 109 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 37 MG/KG 10 22 110 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 23 111 92 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 23 112 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 23 113 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 23 114 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 23 115 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 24 116 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 24 117 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 24 118 92 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 24 119 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 75 MG/KG 10 24 120 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 25 123 92 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 126 92 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 127 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 150 MG/KG 10 26 129 92 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 121 92 1 Basophilic Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 127 92 1 Clear Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 128 92 1 Clear Cell Focus Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 132 92 1 Clear Cell Focus Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 133 92 1 Clear Cell Focus Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 135 92 1 Clear Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 121 92 1 Eosinophilic Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 122 92 1 Eosinophilic Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 125 92 1 Eosinophilic Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 128 92 1 Eosinophilic Focus Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 132 92 1 Eosinophilic Focus Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 135 92 1 Eosinophilic Focus Terminal Sacrifice
Alimentary System Liver Untreated Control 10 15 74 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Untreated Control 10 16 78 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 18 86 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 18 89 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 18 90 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 18 MG/KG 10 19 92 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 18 MG/KG 10 19 93 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 18 MG/KG 10 19 95 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 21 103 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 22 106 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 22 107 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 22 109 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 121 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 126 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 134 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 135 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 28 136 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 21 101 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 21 102 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 22 106 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 22 108 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 37 MG/KG 10 22 109 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 75 MG/KG 10 23 111 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Alimentary System Liver 75 MG/KG 10 23 112 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 75 MG/KG 10 23 113 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 75 MG/KG 10 23 115 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 75 MG/KG 10 24 117 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 75 MG/KG 10 24 119 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 124 92 1 Mixed Cell Focus Accidentally Killed
Alimentary System Liver 150 MG/KG 10 25 121 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 122 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 123 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 125 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 126 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 129 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 130 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 28 137 92 1 Mixed Cell Focus Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 124 92 1 Pigmentation Minimal Accidentally Killed
Alimentary System Liver 150 MG/KG 10 25 121 92 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 122 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 123 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 25 125 92 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 126 92 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 127 92 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 128 92 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 129 92 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver 150 MG/KG 10 26 130 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 131 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 132 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 133 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 134 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 27 135 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 28 136 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 28 137 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 28 138 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 28 139 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 300 MG/KG 10 28 140 92 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Stomach Forestomach 300 MG/KG 10 28 136 92 1 Edema Mild Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 15 71 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 16 77 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 17 85 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Endocrine System Islets Pancreatic 300 MG/KG 10 27 135 92 1 Metaplasia Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Untreated Control 10 16 77 92 1 Ultimobranchial Cyst Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Untreated Control 10 16 78 92 1 Ultimobranchial Cyst Minimal Terminal Sacrifice
Genital System Clitoral Gland Bilateral Untreated Control 10 15 74 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland Bilateral Vehicle Control 10 17 82 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Genital System Clitoral Gland Bilateral 300 MG/KG 10 27 131 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Genital System Clitoral Gland Bilateral 300 MG/KG 10 27 133 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Genital System Clitoral Gland 150 MG/KG 10 25 121 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 27 131 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 27 133 92 1 Atrophy Mild Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 27 134 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 27 135 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 28 136 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 28 137 92 1 Atrophy Mild Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 28 138 92 1 Atrophy Mild Terminal Sacrifice
Genital System Clitoral Gland Untreated Control 10 15 71 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Genital System Clitoral Gland Untreated Control 10 15 72 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Genital System Clitoral Gland Untreated Control 10 16 79 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Genital System Clitoral Gland Untreated Control 10 16 80 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Genital System Clitoral Gland Vehicle Control 10 18 89 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Genital System Clitoral Gland 18 MG/KG 7 20 96 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 37 MG/KG 7 22 109 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 75 MG/KG 10 23 111 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 75 MG/KG 10 23 112 92 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 75 MG/KG 10 23 114 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 75 MG/KG 10 24 118 92 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 150 MG/KG 10 25 124 92 1 Inflammation Minimal, Chronic Active Accidentally Killed
Genital System Clitoral Gland 150 MG/KG 10 26 126 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 150 MG/KG 10 26 127 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 150 MG/KG 10 26 128 92 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 150 MG/KG 10 26 130 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 27 132 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 28 137 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Genital System Clitoral Gland 300 MG/KG 10 28 139 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Genital System Ovary Interstit Cell 150 MG/KG 10 25 121 92 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Genital System Ovary Interstit Cell 150 MG/KG 10 25 125 92 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Genital System Ovary Interstit Cell 150 MG/KG 10 26 126 92 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 27 131 92 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 27 132 92 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 27 133 92 1 Cytoplasmic Alteration Moderate Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 27 134 92 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 27 135 92 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 28 136 92 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 28 137 92 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 28 138 92 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 28 139 92 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Genital System Ovary Interstit Cell 300 MG/KG 10 28 140 92 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Genital System Ovary Vehicle Control 10 18 86 92 1 Cyst Mild Terminal Sacrifice
Genital System Ovary 37 MG/KG 10 22 110 92 1 Cyst Mild Terminal Sacrifice
Genital System Ovary 75 MG/KG 10 23 111 92 1 Cyst Minimal Terminal Sacrifice
Genital System Ovary 75 MG/KG 10 24 116 92 1 Cyst Mild Terminal Sacrifice
Genital System Ovary 75 MG/KG 10 24 120 92 1 Cyst Mild Terminal Sacrifice
Genital System Uterus 150 MG/KG 10 25 124 92 1 Atrophy Mild Accidentally Killed
Genital System Uterus 150 MG/KG 10 25 121 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 150 MG/KG 10 25 122 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Uterus 150 MG/KG 10 25 125 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Uterus 150 MG/KG 10 26 126 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Uterus 150 MG/KG 10 26 127 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Uterus 150 MG/KG 10 26 130 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 27 131 92 1 Atrophy Moderate Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 27 132 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 27 133 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 27 134 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 27 135 92 1 Atrophy Moderate Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 28 136 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 28 137 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 28 138 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 300 MG/KG 10 28 139 92 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus Untreated Control 10 15 71 92 1 Hydrometra Minimal Terminal Sacrifice
Genital System Uterus Untreated Control 10 16 79 92 1 Hydrometra Moderate Terminal Sacrifice
Genital System Uterus Untreated Control 10 16 80 92 1 Hydrometra Moderate Terminal Sacrifice
Genital System Uterus Vehicle Control 10 18 88 92 1 Hydrometra Moderate Terminal Sacrifice
Genital System Uterus 18 MG/KG 10 19 94 92 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 18 MG/KG 10 20 99 92 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 37 MG/KG 10 21 102 92 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 37 MG/KG 10 22 106 92 1 Hydrometra Moderate Terminal Sacrifice
Genital System Uterus 37 MG/KG 10 22 108 92 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 37 MG/KG 10 22 110 92 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 75 MG/KG 10 23 114 92 1 Hydrometra Moderate Terminal Sacrifice
Genital System Uterus 75 MG/KG 10 24 116 92 1 Hydrometra Moderate Terminal Sacrifice
Genital System Uterus 75 MG/KG 10 24 117 92 1 Hydrometra Moderate Terminal Sacrifice
Genital System Uterus 75 MG/KG 10 24 119 92 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 150 MG/KG 10 25 122 92 1 Hydrometra Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 150 MG/KG 10 25 124 92 1 Atrophy Minimal Accidentally Killed
Hematopoietic System Bone Marrow 150 MG/KG 10 25 121 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 150 MG/KG 10 25 125 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 150 MG/KG 10 26 126 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 300 MG/KG 10 27 131 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 300 MG/KG 10 27 133 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 300 MG/KG 10 27 134 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 300 MG/KG 10 27 135 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 300 MG/KG 10 28 138 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 300 MG/KG 10 28 139 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 300 MG/KG 10 28 140 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular Vehicle Control 10 18 87 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 300 MG/KG 10 27 134 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular Vehicle Control 10 17 82 92 1 Hyperplasia Minimal, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Untreated Control 10 16 78 92 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Untreated Control 10 16 79 92 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 18 90 92 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Hematopoietic System Spleen Lymph Follic 300 MG/KG 10 28 136 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Lymph Follic 300 MG/KG 10 28 139 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Lymph Follic 300 MG/KG 10 28 140 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 27 131 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 27 132 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 27 133 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 27 134 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 27 135 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 28 136 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 28 138 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 28 139 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 300 MG/KG 10 28 140 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 18 90 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 75 MG/KG 10 23 112 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 75 MG/KG 10 23 115 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 75 MG/KG 10 24 118 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 75 MG/KG 10 24 120 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 150 MG/KG 10 25 124 92 1 Pigmentation Mild Accidentally Killed
Hematopoietic System Spleen 150 MG/KG 10 25 123 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 150 MG/KG 10 25 125 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 150 MG/KG 10 26 126 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 150 MG/KG 10 26 127 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 150 MG/KG 10 26 128 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 150 MG/KG 10 26 129 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 150 MG/KG 10 26 130 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 300 MG/KG 10 27 131 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 300 MG/KG 10 27 132 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 300 MG/KG 10 27 133 92 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 300 MG/KG 10 27 134 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 300 MG/KG 10 27 135 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 300 MG/KG 10 28 137 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 300 MG/KG 10 28 139 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 300 MG/KG 10 28 140 92 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Thymus Vehicle Control 10 17 83 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Thymus Vehicle Control 10 18 86 92 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Thymus Vehicle Control 10 18 90 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Thymus 300 MG/KG 10 27 135 92 1 Hemorrhage Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 300 MG/KG 10 28 140 92 1 Atrophy Mild Terminal Sacrifice
Integumentary System Skin Vehicle Control 10 17 81 92 1 Hemorrhage Mild Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 25 124 92 1 Atrophy Mild Accidentally Killed
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 25 121 92 1 Atrophy Mild Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 25 122 92 1 Atrophy Minimal Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 25 123 92 1 Atrophy Mild Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 25 125 92 1 Atrophy Mild Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 26 126 92 1 Atrophy Mild Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 26 128 92 1 Atrophy Minimal Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 26 129 92 1 Atrophy Mild Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 150 MG/KG 10 26 130 92 1 Atrophy Mild Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 27 131 92 1 Atrophy Moderate Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 27 132 92 1 Atrophy Minimal Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 27 133 92 1 Atrophy Moderate Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 27 134 92 1 Atrophy Moderate Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 27 135 92 1 Atrophy Moderate Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 28 136 92 1 Atrophy Mild Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 28 138 92 1 Atrophy Moderate Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 28 139 92 1 Atrophy Marked Terminal Sacrifice
Musculoskeletal System Bone Metaphysis 300 MG/KG 10 28 140 92 1 Atrophy Marked Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 17 82 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 300 MG/KG 10 28 138 92 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Nose Vehicle Control 10 17 82 92 1 Foreign Body Terminal Sacrifice
Respiratory System Nose Vehicle Control 10 17 82 92 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Trachea Vehicle Control 10 17 82 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 15 71 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 15 72 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 15 73 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 15 74 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 15 75 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 16 77 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 16 78 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 16 79 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Untreated Control 10 16 80 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 17 81 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 17 82 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 17 83 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 17 84 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 17 85 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 18 86 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 18 87 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 18 88 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 18 89 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral Vehicle Control 10 18 90 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral 150 MG/KG 1 25 124 92 1 Mineralization Minimal Accidentally Killed
Urinary System Kidney Bilateral 300 MG/KG 10 27 131 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 27 132 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 27 133 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 27 134 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 27 135 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 28 136 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 28 137 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 28 138 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 28 139 92 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Bilateral 300 MG/KG 10 28 140 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Bilateral, Pelvis Vehicle Control 10 18 88 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Urinary System Kidney Bilateral, Renal Tubule 300 MG/KG 10 27 132 92 1 Degeneration Mild Terminal Sacrifice
Urinary System Kidney Pelvis Vehicle Control 10 17 84 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Urinary System Kidney Pelvis, Transit Epithe Vehicle Control 10 18 88 92 1 Hyperplasia Mild Terminal Sacrifice
Urinary System Kidney Renal Tubule 300 MG/KG 10 27 133 92 1 Degeneration Minimal Terminal Sacrifice
Urinary System Kidney Untreated Control 10 16 76 92 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 17 84 92 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Urinary Bladder Vehicle Control 10 18 88 92 1 Inflammation Mild, Chronic Terminal Sacrifice