If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 1,1,2,2-Tetrachloroethane
CASRN: ="79-34-5"
Study Number: C03554E
Exposure Route: DOSED FEED
TDMS Number: 0355412
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Gallbladder Untreated Control 10 1 1 92 1 Inflammation Moderate Terminal Sacrifice
Alimentary System Liver Bile Duct 350 MG/KG 10 41 41 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 350 MG/KG 10 42 42 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 350 MG/KG 10 44 44 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 350 MG/KG 10 45 45 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 350 MG/KG 10 46 46 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 350 MG/KG 10 48 48 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 350 MG/KG 10 49 49 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 51 51 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 52 52 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 53 53 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 54 54 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 55 55 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 56 56 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 58 58 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 59 59 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 700 MG/KG 10 60 60 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver Bile Duct 1400 MG/KG 10 68 68 92 1 Hyperplasia Mild Accidentally Killed
Alimentary System Liver Bile Duct 1400 MG/KG 10 69 69 92 1 Hyperplasia Mild Accidentally Killed
Alimentary System Liver Bile Duct 1400 MG/KG 10 61 61 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 1400 MG/KG 10 62 62 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 1400 MG/KG 10 63 63 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 1400 MG/KG 10 64 64 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 1400 MG/KG 10 65 65 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 1400 MG/KG 10 66 66 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 1400 MG/KG 10 67 67 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Bile Duct 1400 MG/KG 10 70 70 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 175 MG/KG 10 31 31 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 175 MG/KG 10 35 35 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 175 MG/KG 10 36 36 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 175 MG/KG 10 37 37 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 175 MG/KG 10 38 38 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 175 MG/KG 10 39 39 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 175 MG/KG 10 40 40 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 43 43 92 1 Hypertrophy Mild Accidentally Killed
Alimentary System Liver Hepatocyte 350 MG/KG 10 41 41 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 42 42 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 44 44 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 45 45 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 46 46 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 47 47 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 48 48 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 49 49 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 50 50 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 51 51 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 52 52 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 53 53 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 54 54 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 55 55 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 56 56 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 57 57 92 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 58 58 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 59 59 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 60 60 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 68 68 92 1 Hypertrophy Moderate Accidentally Killed
Alimentary System Liver Hepatocyte 1400 MG/KG 10 69 69 92 1 Hypertrophy Marked Accidentally Killed
Alimentary System Liver Hepatocyte 1400 MG/KG 10 61 61 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 62 62 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 63 63 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 64 64 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 65 65 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 66 66 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 67 67 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 70 70 92 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 175 MG/KG 10 39 39 92 1 Necrosis Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 43 43 92 1 Necrosis Minimal Accidentally Killed
Alimentary System Liver Hepatocyte 350 MG/KG 10 42 42 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 44 44 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 45 45 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 46 46 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 47 47 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 48 48 92 1 Necrosis Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 350 MG/KG 10 49 49 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 51 51 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 52 52 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 54 54 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 55 55 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 56 56 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 58 58 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 59 59 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 700 MG/KG 10 60 60 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 68 68 92 1 Necrosis Minimal Accidentally Killed
Alimentary System Liver Hepatocyte 1400 MG/KG 10 69 69 92 1 Necrosis Minimal Accidentally Killed
Alimentary System Liver Hepatocyte 1400 MG/KG 10 62 62 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 63 63 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 64 64 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 65 65 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 66 66 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 67 67 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1400 MG/KG 10 70 70 92 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 12 12 92 1 Inflammation Minimal, Focal Accidentally Killed
Alimentary System Liver Untreated Control 10 10 10 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver Untreated Control 10 9 9 92 1 Inflammation Mild, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 11 11 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 1400 MG/KG 10 62 62 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 13 13 92 1 Necrosis Minimal, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 14 14 92 1 Necrosis Mild, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 43 43 92 1 Pigmentation Minimal, Focal Accidentally Killed
Alimentary System Liver 350 MG/KG 10 41 41 92 1 Pigmentation Mild, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 42 42 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 44 44 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 45 45 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 46 46 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 47 47 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 48 48 92 1 Pigmentation Mild, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 49 49 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 350 MG/KG 10 50 50 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 51 51 92 1 Pigmentation Mild, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 52 52 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 53 53 92 1 Pigmentation Mild, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 54 54 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 55 55 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 56 56 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 57 57 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 58 58 92 1 Pigmentation Mild, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 59 59 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 700 MG/KG 10 60 60 92 1 Pigmentation Mild, Focal Terminal Sacrifice
Alimentary System Liver 1400 MG/KG 10 69 69 92 1 Pigmentation Mild, Focal Accidentally Killed
Alimentary System Liver 1400 MG/KG 10 62 62 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 1400 MG/KG 10 63 63 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 1400 MG/KG 10 64 64 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 1400 MG/KG 10 65 65 92 1 Pigmentation Mild, Focal Terminal Sacrifice
Alimentary System Liver 1400 MG/KG 10 66 66 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 1400 MG/KG 10 67 67 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 1400 MG/KG 10 70 70 92 1 Pigmentation Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Glandular Untreated Control 10 3 3 92 1 Cyst Minimal Terminal Sacrifice
Alimentary System Stomach Glandular Untreated Control 10 9 9 92 1 Cyst Minimal Terminal Sacrifice
Alimentary System Stomach Glandular 1400 MG/KG 10 64 64 92 1 Cyst Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Capsule Vehicle Control 10 12 12 92 1 Hyperplasia Minimal Accidentally Killed
Endocrine System Adrenal Cortex Capsule Untreated Control 10 10 10 92 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Capsule 1400 MG/KG 10 69 69 92 1 Hyperplasia Minimal Accidentally Killed
Endocrine System Adrenal Cortex Capsule 1400 MG/KG 10 63 63 92 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Capsule 1400 MG/KG 10 64 64 92 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Medulla Untreated Control 10 7 7 92 1 Angiectasis Minimal Terminal Sacrifice
Endocrine System Adrenal Medulla Vehicle Control 10 18 18 92 1 Angiectasis Minimal Terminal Sacrifice
Endocrine System Adrenal Medulla Vehicle Control 10 20 20 92 1 Angiectasis Mild Terminal Sacrifice
Endocrine System Adrenal Medulla 1400 MG/KG 10 66 66 92 1 Angiectasis Minimal Terminal Sacrifice
Endocrine System Pituitary Gland 1400 MG/KG 10 62 62 92 1 Cyst Mild Terminal Sacrifice
Genital System Preputial Gland 88 MG/KG 10 23 23 92 1 Atrophy Mild Terminal Sacrifice
Genital System Preputial Gland 88 MG/KG 10 24 24 92 1 Atrophy Mild Terminal Sacrifice
Genital System Preputial Gland 88 MG/KG 10 25 25 92 1 Atrophy Mild Terminal Sacrifice
Genital System Preputial Gland 88 MG/KG 10 29 29 92 1 Atrophy Mild Terminal Sacrifice
Genital System Preputial Gland 175 MG/KG 10 35 35 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Preputial Gland 175 MG/KG 10 39 39 92 1 Atrophy Minimal Terminal Sacrifice
Genital System Preputial Gland 700 MG/KG 10 53 53 92 1 Atrophy Moderate Terminal Sacrifice
Genital System Preputial Gland 700 MG/KG 10 54 54 92 1 Atrophy Mild Terminal Sacrifice
Genital System Preputial Gland 700 MG/KG 10 56 56 92 1 Atrophy Moderate Terminal Sacrifice
Genital System Preputial Gland 700 MG/KG 10 58 58 92 1 Atrophy Mild Terminal Sacrifice
Genital System Preputial Gland 1400 MG/KG 9 69 69 92 1 Atrophy Minimal Accidentally Killed
Genital System Preputial Gland 1400 MG/KG 9 62 62 92 1 Atrophy Mild Terminal Sacrifice
Genital System Preputial Gland 1400 MG/KG 9 64 64 92 1 Atrophy Moderate Terminal Sacrifice
Genital System Preputial Gland 1400 MG/KG 9 65 65 92 1 Atrophy Mild Terminal Sacrifice
Genital System Preputial Gland 1400 MG/KG 9 66 66 92 1 Atrophy Moderate Terminal Sacrifice
Genital System Preputial Gland 1400 MG/KG 9 64 64 92 1 Inflammation Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular Untreated Control 10 9 9 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular Vehicle Control 10 11 11 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 1400 MG/KG 10 65 65 92 1 Infiltration Cellular Mild, Mast Cell Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 700 MG/KG 8 53 53 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 700 MG/KG 8 59 59 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1400 MG/KG 10 64 64 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1400 MG/KG 10 65 65 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1400 MG/KG 10 66 66 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 18 18 92 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 1400 MG/KG 10 61 61 92 1 Necrosis Moderate Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 1400 MG/KG 10 62 62 92 1 Necrosis Moderate Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 1400 MG/KG 10 64 64 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus 700 MG/KG 10 54 54 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 1400 MG/KG 10 62 62 92 1 Atrophy Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 88 MG/KG 1 26 26 92 1 Atrophy Marked Terminal Sacrifice
Urinary System Kidney Untreated Control 10 10 10 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice