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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 3,3',4,4'-Tetrachloroazobenzene
CASRN: ="14047-09-7"
Study Number: C88148
Exposure Route: GAVAGE
TDMS Number: 8814803
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver 0.1 MG/KG 1 16 78 92 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 1 MG/KG 1 17 84 92 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 30 MG/KG 10 23 111 92 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 14 66 92 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 10 MG/KG 10 22 108 92 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 30 MG/KG 10 23 111 92 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 14 66 92 1 Necrosis Minimal, Focal Terminal Sacrifice
Alimentary System Mesentery Fat 10 MG/KG 1 22 110 92 1 Necrosis Mild, Focal Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 13 64 92 1 Atrophy Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 1 18 87 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 19 95 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 21 101 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 22 106 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 23 114 92 1 Hyperplasia Mild, Focal Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 23 111 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 23 112 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 23 113 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 23 115 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 24 116 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 24 117 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 24 118 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 24 119 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 24 120 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 13 65 92 1 Degeneration Minimal, Focal Terminal Sacrifice
Genital System Clitoral Gland Vehicle Control 10 14 68 92 1 Inflammation Mild, Focal Terminal Sacrifice
Genital System Ovary 30 MG/KG 10 23 113 92 1 Cyst Mild Terminal Sacrifice
Genital System Uterus Vehicle Control 10 13 63 92 1 Hydrometra Minimal Terminal Sacrifice
Genital System Uterus 0.1 MG/KG 1 15 71 92 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 30 MG/KG 10 23 113 92 1 Hydrometra Minimal Terminal Sacrifice
Genital System Uterus 30 MG/KG 10 24 118 92 1 Hydrometra Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular Vehicle Control 10 14 66 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 30 MG/KG 10 23 114 92 1 Inflammation Mild, Granulomatous Accidentally Killed
Hematopoietic System Lymph Node Mesenteric 30 MG/KG 10 23 113 92 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 21 104 92 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 22 106 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 22 108 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 22 109 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 22 110 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 23 114 92 1 Hematopoietic Cell Proliferation Mild Accidentally Killed
Hematopoietic System Spleen 30 MG/KG 10 23 111 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 23 112 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 23 113 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 23 115 92 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 24 116 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 24 117 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 24 119 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 24 120 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 22 106 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 22 108 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 23 114 92 1 Pigmentation Minimal Accidentally Killed
Hematopoietic System Spleen 30 MG/KG 10 23 112 92 1 Pigmentation Moderate Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 23 113 92 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 23 115 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 24 116 92 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 24 117 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 24 118 92 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 24 119 92 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Thymus 3 MG/KG 10 19 94 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus 3 MG/KG 10 20 99 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 10 MG/KG 10 21 103 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 10 MG/KG 10 21 104 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 10 MG/KG 10 22 108 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 23 114 92 1 Atrophy Minimal Accidentally Killed
Hematopoietic System Thymus 30 MG/KG 10 23 111 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 23 112 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 23 113 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 23 115 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 24 116 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 24 117 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 24 118 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 24 120 92 1 Atrophy Mild Terminal Sacrifice
Respiratory System Lung Alveolar Epith Vehicle Control 10 13 63 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Respiratory System Lung Alveolar Epith Vehicle Control 10 14 69 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Respiratory System Lung Alveolar Epith Vehicle Control 10 14 70 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Respiratory System Lung Alveolar Epith 30 MG/KG 10 23 114 92 1 Hyperplasia Mild, Focal Accidentally Killed
Respiratory System Lung Alveolar Epith 30 MG/KG 10 23 111 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Respiratory System Lung Alveolar Epith 30 MG/KG 10 23 113 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Respiratory System Lung Alveolar Epith 30 MG/KG 10 23 115 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Respiratory System Lung Alveolar Epith 30 MG/KG 10 24 116 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Respiratory System Lung Alveolar Epith 30 MG/KG 10 24 120 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 13 65 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 66 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 69 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 24 119 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 24 120 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 13 61 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 13 63 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 13 64 92 1 Infiltration Cellular Mild, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 13 65 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 66 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 68 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 70 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 23 114 92 1 Infiltration Cellular Mild, Focal, Lymphocyte Accidentally Killed
Respiratory System Lung 30 MG/KG 10 23 115 92 1 Infiltration Cellular Mild, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 24 116 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 24 118 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 24 120 92 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 13 64 92 1 Inflammation Minimal, Focal, Granulomatous Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 23 111 92 1 Inflammation Mild, Focal, Chronic Active Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 23 113 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 23 115 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 24 117 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 13 61 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 13 62 92 1 Mineralization Mild, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 13 63 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 13 64 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 13 65 92 1 Mineralization Mild, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 14 66 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 14 67 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 14 68 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 14 69 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 14 70 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 23 111 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 23 112 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 23 115 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 24 116 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 24 117 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 24 118 92 1 Mineralization Minimal, Focal Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 24 120 92 1 Mineralization Minimal, Focal Terminal Sacrifice