If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 3,3',4,4'-Tetrachloroazobenzene
CASRN: ="14047-09-7"
Study Number: C88148
Exposure Route: GAVAGE
TDMS Number: 8814804
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Muscularis Vehicle Control 10 2 2 92 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Centrilobular 1 MG/KG 10 29 29 92 1 Hypertrophy Minimal Accidentally Killed
Alimentary System Liver Centrilobular 1 MG/KG 10 22 22 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 3 MG/KG 10 37 37 92 1 Hypertrophy Minimal Accidentally Killed
Alimentary System Liver Centrilobular 3 MG/KG 10 33 33 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 3 MG/KG 10 35 35 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 3 MG/KG 10 39 39 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10 MG/KG 10 46 46 92 1 Hypertrophy Minimal Accidentally Killed
Alimentary System Liver Centrilobular 10 MG/KG 10 41 41 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10 MG/KG 10 42 42 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10 MG/KG 10 43 43 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10 MG/KG 10 44 44 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10 MG/KG 10 48 48 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10 MG/KG 10 49 49 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10 MG/KG 10 50 50 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 52 52 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 53 53 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 54 54 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 55 55 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 56 56 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 57 57 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 58 58 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 59 59 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 30 MG/KG 10 60 60 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte Vehicle Control 10 1 1 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1 MG/KG 10 30 30 92 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 10 MG/KG 10 42 42 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 30 MG/KG 10 54 54 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 30 MG/KG 10 56 56 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 30 MG/KG 10 60 60 92 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver 30 MG/KG 10 52 52 92 1 Inflammation Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 0.1 MG/KG 10 15 15 92 1 Hyperplasia Mild Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 0.1 MG/KG 10 14 14 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 10 29 29 92 1 Hyperplasia Mild Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 10 22 22 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 10 23 23 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 10 24 24 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 10 25 25 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 10 26 26 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 34 34 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 35 35 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 39 39 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 46 46 92 1 Hyperplasia Minimal Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 42 42 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 48 48 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 49 49 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 51 51 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 52 52 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 56 56 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 58 58 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 59 59 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 60 60 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Glandular 30 MG/KG 10 56 56 92 1 Cyst Mild Terminal Sacrifice
Cardiovascular System Blood Vessel Adventitia Vehicle Control 10 3 3 92 1 Inflammation Mild Accidentally Killed
Cardiovascular System Heart 30 MG/KG 10 56 56 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 9 9 92 1 Hematopoietic Cell Proliferation Minimal Accidentally Killed
Hematopoietic System Spleen Red Pulp Vehicle Control 10 1 1 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 10 10 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 8 8 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 12 12 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 13 13 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 14 14 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 16 16 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 17 17 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 18 18 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 19 19 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 20 20 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 21 21 92 1 Hematopoietic Cell Proliferation Minimal Accidentally Killed
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 29 29 92 1 Hematopoietic Cell Proliferation Minimal Accidentally Killed
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 22 22 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 23 23 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 25 25 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 26 26 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 27 27 92 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 31 31 92 1 Hematopoietic Cell Proliferation Minimal Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 32 32 92 1 Hematopoietic Cell Proliferation Minimal Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 37 37 92 1 Hematopoietic Cell Proliferation Minimal Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 38 38 92 1 Hematopoietic Cell Proliferation Minimal Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 33 33 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 34 34 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 35 35 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 39 39 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 40 40 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 46 46 92 1 Hematopoietic Cell Proliferation Minimal Accidentally Killed
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 41 41 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 42 42 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 43 43 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 44 44 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 45 45 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 47 47 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 48 48 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 49 49 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 50 50 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 51 51 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 52 52 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 53 53 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 54 54 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 55 55 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 56 56 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 57 57 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 58 58 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 59 59 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 60 60 92 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 51 51 92 1 Pigmentation Mild Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 9 9 92 1 Inflammation Minimal, Focal, Chronic Accidentally Killed
Urinary System Kidney 30 MG/KG 10 58 58 92 1 Inflammation Mild, Focal, Chronic Terminal Sacrifice
Urinary System Urethra 0.1 MG/KG 10 17 17 92 1 Hyperplasia Mild Terminal Sacrifice
Urinary System Urethra 30 MG/KG 10 56 56 92 1 Hyperplasia Moderate Terminal Sacrifice